Perinatal asphyxia partly affects presepsin urine levels in non-infected term infants

V. Botondi, A. Pirra, M. Strozzi, M. Perrotta, D.A.W. Gavilanes, L. Di Ricco, C. Spagnuolo, A. Maconi, A. Rocchetti, L. Mazzucco, V. Balbo, F. Schena, G. Stellitano, A. Oddi, A. Dotta, I. Bersani, A. Sannia, C. Peila, E. Bertino, I. BiancoA. Gambi, R. Mangifesta, D. Gazzolo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Objectives Standard of care sepsis biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT) can be affected by several perinatal factors, among which perinatal asphyxia (PA) has a significant role. In this light, new early sepsis biomarkers such as presepsin (P-SEP) are needed to enact therapeutic strategies at a stage when clinical and laboratory patterns are still silent or unavailable. We aimed at investigating the potential effects of PA on longitudinal P-SEP urine levels. Methods We conducted an observational case-control study in 76 term infants, 38 with PA and 38 controls. Standard clinical, laboratory, radiological monitoring procedures and P-SEP urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Results Higher (p<0.05) CRP and PCT blood levels at T1-T3 were observed in PA than control infants whilst no differences (p>0.05, for all) at T0 were observed between groups. P-SEP urine levels were higher (p<0.05) in PA at first void and at 24 h while no differences (p>0.05) at 48 and 96 h were observed. No significant correlations were found (p>0.05) between P-SEP and urea (R=0.11) and creatinine (R=0.02) blood levels, respectively. Conclusions The present results, showed that PA effects on P-SEP were limited up to the first 24 h following birth in absence of any kidney function bias. Data open the way to further investigations aimed at validating P-SEP assessment in non-invasive biological fluids as a reliable tool for early EOS and LOS detection in high-risk infants.
Original languageEnglish
Pages (from-to)793-799
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Volume60
Issue number5
Early online date4 Feb 2022
DOIs
Publication statusPublished - 26 Apr 2022

Keywords

  • kidney
  • newborn
  • perinatal asphyxia (PA)
  • presepsin (P-SEP)
  • sepsis
  • BRAIN-DAMAGE
  • BIOMARKERS
  • SCD14-ST
  • HYPOXIA
  • SEPSIS
  • CELLS

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