Perinatal and Pediatric Outcome of Pregnancies Following PGT-M/SR/A

Perinatal and pediatric outcomes of pregnancies following PGT-M/SR/A have been studied tremendously since concerns regarding the outcome were raised based on the Developmental Origin of Health and Disease Hypothesis. The application of PGT, very briefly described as IVF with the biopsy of embryonic cell(s), may introduce extra stressors during early embryonic life, resulting in adverse outcomes later in life. Several studies conclude that the risk for obstetric complications and adverse perinatal outcome, as well as the physical health and development of young children born following PGT, do not seem to be affected by the PGT procedure. These conclusions are promising, though they are mostly based on results from PGT treatments performed in the early years of PGT and thus do not include data from PGT procedures with newer techniques like trophectoderm biopsy and/or genome wide genetic analysis. Also, data regarding the health of older children and adults born following PGT are scarce. In conclusion, PGT seems to be an overall safe procedure, but ongoing follow-up studies are desirable.