Performance of osteoinductive biphasic calcium-phosphate ceramic in a critical-sized defect in goats

P Habibovic*, M van den Doel, CA van Blitterswijk, K de Groot

*Corresponding author for this work

Research output: Contribution to journalConference article in journalAcademicpeer-review


Osteoinductive biomaterials are able of inducing bone formation at ectopic, i.e. extraskeletal implantation sites. It is, however, important to investigate whether osteoinductive biomaterials perform better when implanted orthotopically as well, in particular in clinically relevant critical-sized defects. In this study, an osteoinductive and a non-osteoinductive biphasic calcium-phosphate (BCP) ceramic were compared in a critical-sized iliac wing defect that allows for paired comparison. After 12 weeks of implantation in the critical-sized defect, the osteoinductive BCP1150 ceramic showed significantly more bone than the non-osteoinductive BCP1300 ceramic. In addition, the analysis of fluorochrome markers, which were administered to the animals 4, 6 and 8 weeks after implantation in order to visualize the bone growth dynamics, showed an earlier start of bone formation in BCP1150 as compared to BCP1300. Significantly better performance of osteoinductive ceramic in a critical-sized orthotopic defect in a large animal model in comparison to the non-osteoinductive ceramic suggests osteoinduction to be clinically relevant.

Original languageEnglish
Pages (from-to)1303-1306
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2006
Externally publishedYes
Event18th International Symposium on Ceramics in Medicine - Kyoto, Japan
Duration: 5 Dec 20058 Dec 2005


  • biphasic calcium-phosphate
  • ceramic
  • osteoinduction
  • in vivo
  • critical-sized defect


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