PEOT/PBT Polymeric Pastes to Fabricate Additive Manufactured Scaffolds for Tissue Engineering

G.A. Higuera, T. Ramos, A. Gloria, L. Ambrosio, A. Di Luca, N. Pechkov, J.R. de Wijn, C.A. van Blitterswijk, L. Moroni*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The advantages of additive manufactured scaffolds, as custom-shaped structures with a completely interconnected and accessible pore network from the micro- to the macroscale, are nowadays well established in tissue engineering. Pore volume and architecture can be designed in a controlled fashion, resulting in a modulation of scaffold's mechanical properties and in an optimal nutrient perfusion determinant for cell survival. However, the success of an engineered tissue architecture is often linked to its surface properties as well. The aim of this study was to create a family of polymeric pastes comprised of poly(ethylene oxide therephthalate)/poly(butylene terephthalate) (PEOT/PBT) microspheres and of a second biocompatible polymeric phase acting as a binder. By combining microspheres with additive manufacturing technologies, we produced 3D scaffolds possessing a tailorable surface roughness, which resulted in improved cell adhesion and increased metabolic activity. Furthermore, these scaffolds may offer the potential to act as drug delivery systems to steer tissue regeneration.</p>
Original languageEnglish
Article number704185
Number of pages13
JournalFrontiers in bioengineering and biotechnology
Volume9
DOIs
Publication statusPublished - 14 Sep 2021

Keywords

  • microparticles
  • additive manufacturing
  • tissue engineering
  • polymers
  • mesenchymal stem cells
  • mechanical analysis
  • OSTEOCHONDRAL INTERFACE REGENERATION
  • IN-VITRO
  • MACROSCOPIC GRADIENTS
  • STEM-CELLS
  • DESIGN
  • MICROSPHERES
  • RELEASE
  • BIOMATERIALS
  • MODEL
  • DIFFERENTIATION

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