Pelvic organ prolapse after laparoscopic hysterectomy compared with vaginal hysterectomy: the POP-UP study

C.K.M. Vermeulen*, J. Veen, C. Adang, S.A.L. van Leijsen, A.L.W.M. Coolen, M.Y. Bongers

*Corresponding author for this work

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Introduction and hypothesis The objective was to review the long-term prevalence of pelvic organ prolapse (POP) after laparoscopic hysterectomy (LH) compared with vaginal hysterectomy (VH). Methods An observational cohort study was conducted amongst women who underwent an LH or a VH for benign indications during the period 1996-2004: the POP-UP study. The prevalence of POP was inventoried by a questionnaire involving the Pelvic Floor Distress Inventory (PFDI-20) and a pelvic floor examination (POP-Q). Women were divided into groups based on route and indication of hysterectomy: LH, VH-1 (for nonprolapse), and VH-2 (prolapse). Results Four hundred and six of the 706 eligible patients (58%) returned the questionnaire and 247 underwent POP-Q examination. Sixty-eight patients (17%) received treatment for prolapse; 8% LH, 10% VH-1, and 29% VH-2 (Chi-squared test, p < 0.001). The prevalence of vaginal vault prolapse (apical surgery or >= stage 2 at POP-Q) was 4.4% for LH and 5.8% for VH-1 (p = 0.707); and 23% for VH-2 (VH-2 versus others, p < 0.0001). The prevalence of prolapse >= stage 2 in any compartment was 62% (n = 153) in total and in 42% of the LH group, 51% of the VH-1 group, and 84% of the VH-2 group (Chi-squared test, p < 0.001). A symptomatic POP (anatomical POP >= stage 2 with bulging) was present in 11% of the population. Conclusions No difference was found in the prevalence of POP between LH and VH for nonprolapse indications. However, POP after VH for prolapse occurs more frequently than after hysterectomy for other indications.
Original languageEnglish
Pages (from-to)841-850
Number of pages10
JournalInternational Urogynecology Journal
Issue number4
Early online date10 Nov 2020
Publication statusPublished - Apr 2021


  • disorders
  • epidemiology
  • hysterectomy
  • laparoscopic hysterectomy
  • pelvic organ prolapse
  • prevalence
  • repair
  • risk-factors
  • surgery
  • symptoms
  • vaginal hysterectomy
  • women
  • Vaginal hysterectomy
  • Pelvic organ prolapse
  • Epidemiology
  • Hysterectomy
  • Laparoscopic hysterectomy

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