PDE2 and PDE10, but not PDE5, inhibition affect basic auditory information processing in rats

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Phosphodiesterase type 2 (PDE2), type 10 (PDE10), and type 5 (PDE5) have been considered as relevant targets for cognition enhancement. Although it is well established that PDE inhibitors (PDE-Is) improve memory functions in animals, the effects on auditory information processing are less clear. The aim of this study was to test the effects of PDE2 (BAY 60-7550), PDE5 (vardenafil) and PDE10 (PQ-10) inhibition on sensory gating in rats. Vehicle or 1mg/kg of a specific PDE-I was given orally 30min before testing. EEG was recorded from the hippocampus, striatum and vertex. Sensory gating was found for the N1 in the vertex and hippocampus, as revealed by diminished amplitudes to S2 compared to S1. Administration of PDE-Is did not affect sensory gating. However, PDE2 inhibition increased the P1 peak after presentation of S1 at the vertex and PQ-10 increased the N1 peak in general compared to vehicle treatment at the hippocampus. PDE2 and PDE10 inhibition affect auditory information processing in general, whereas PDE5 inhibition has no effect. These findings suggest that the positive effects of PDE5 inhibition on cognition previously found in animals are possibly the results of an effect on higher cognitive functioning specifically, whereas the cognition enhancing effects of PDE2 and PDE10 inhibition might also be influenced by effects on earlier stages of information processing.
Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalBehavioural Brain Research
Volume250
DOIs
Publication statusPublished - 1 Aug 2013

Keywords

  • Sensory gating
  • PDE2
  • PDE5
  • PDE10
  • Auditory information processing
  • Schizophrenia
  • SELECTIVE PHOSPHODIESTERASE INHIBITORS
  • SENSORY-GATING DEFICIT
  • RECOGNITION MEMORY
  • ALZHEIMERS-DISEASE
  • NUCLEOTIDE PHOSPHODIESTERASE
  • PREPULSE INHIBITION
  • LEARNING IMPAIRMENT
  • EVOKED POTENTIALS
  • OBJECT MEMORY
  • SINGLE-UNIT

Cite this

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title = "PDE2 and PDE10, but not PDE5, inhibition affect basic auditory information processing in rats",
abstract = "Phosphodiesterase type 2 (PDE2), type 10 (PDE10), and type 5 (PDE5) have been considered as relevant targets for cognition enhancement. Although it is well established that PDE inhibitors (PDE-Is) improve memory functions in animals, the effects on auditory information processing are less clear. The aim of this study was to test the effects of PDE2 (BAY 60-7550), PDE5 (vardenafil) and PDE10 (PQ-10) inhibition on sensory gating in rats. Vehicle or 1mg/kg of a specific PDE-I was given orally 30min before testing. EEG was recorded from the hippocampus, striatum and vertex. Sensory gating was found for the N1 in the vertex and hippocampus, as revealed by diminished amplitudes to S2 compared to S1. Administration of PDE-Is did not affect sensory gating. However, PDE2 inhibition increased the P1 peak after presentation of S1 at the vertex and PQ-10 increased the N1 peak in general compared to vehicle treatment at the hippocampus. PDE2 and PDE10 inhibition affect auditory information processing in general, whereas PDE5 inhibition has no effect. These findings suggest that the positive effects of PDE5 inhibition on cognition previously found in animals are possibly the results of an effect on higher cognitive functioning specifically, whereas the cognition enhancing effects of PDE2 and PDE10 inhibition might also be influenced by effects on earlier stages of information processing.",
keywords = "Sensory gating, PDE2, PDE5, PDE10, Auditory information processing, Schizophrenia, SELECTIVE PHOSPHODIESTERASE INHIBITORS, SENSORY-GATING DEFICIT, RECOGNITION MEMORY, ALZHEIMERS-DISEASE, NUCLEOTIDE PHOSPHODIESTERASE, PREPULSE INHIBITION, LEARNING IMPAIRMENT, EVOKED POTENTIALS, OBJECT MEMORY, SINGLE-UNIT",
author = "O.A.H. Reneerkens and A. Sambeth and A. Blokland and J. Prickaerts",
year = "2013",
month = "8",
day = "1",
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language = "English",
volume = "250",
pages = "251--256",
journal = "Behavioural Brain Research",
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PDE2 and PDE10, but not PDE5, inhibition affect basic auditory information processing in rats. / Reneerkens, O.A.H.; Sambeth, A.; Blokland, A.; Prickaerts, J.

In: Behavioural Brain Research, Vol. 250, 01.08.2013, p. 251-256.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - PDE2 and PDE10, but not PDE5, inhibition affect basic auditory information processing in rats

AU - Reneerkens, O.A.H.

AU - Sambeth, A.

AU - Blokland, A.

AU - Prickaerts, J.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Phosphodiesterase type 2 (PDE2), type 10 (PDE10), and type 5 (PDE5) have been considered as relevant targets for cognition enhancement. Although it is well established that PDE inhibitors (PDE-Is) improve memory functions in animals, the effects on auditory information processing are less clear. The aim of this study was to test the effects of PDE2 (BAY 60-7550), PDE5 (vardenafil) and PDE10 (PQ-10) inhibition on sensory gating in rats. Vehicle or 1mg/kg of a specific PDE-I was given orally 30min before testing. EEG was recorded from the hippocampus, striatum and vertex. Sensory gating was found for the N1 in the vertex and hippocampus, as revealed by diminished amplitudes to S2 compared to S1. Administration of PDE-Is did not affect sensory gating. However, PDE2 inhibition increased the P1 peak after presentation of S1 at the vertex and PQ-10 increased the N1 peak in general compared to vehicle treatment at the hippocampus. PDE2 and PDE10 inhibition affect auditory information processing in general, whereas PDE5 inhibition has no effect. These findings suggest that the positive effects of PDE5 inhibition on cognition previously found in animals are possibly the results of an effect on higher cognitive functioning specifically, whereas the cognition enhancing effects of PDE2 and PDE10 inhibition might also be influenced by effects on earlier stages of information processing.

AB - Phosphodiesterase type 2 (PDE2), type 10 (PDE10), and type 5 (PDE5) have been considered as relevant targets for cognition enhancement. Although it is well established that PDE inhibitors (PDE-Is) improve memory functions in animals, the effects on auditory information processing are less clear. The aim of this study was to test the effects of PDE2 (BAY 60-7550), PDE5 (vardenafil) and PDE10 (PQ-10) inhibition on sensory gating in rats. Vehicle or 1mg/kg of a specific PDE-I was given orally 30min before testing. EEG was recorded from the hippocampus, striatum and vertex. Sensory gating was found for the N1 in the vertex and hippocampus, as revealed by diminished amplitudes to S2 compared to S1. Administration of PDE-Is did not affect sensory gating. However, PDE2 inhibition increased the P1 peak after presentation of S1 at the vertex and PQ-10 increased the N1 peak in general compared to vehicle treatment at the hippocampus. PDE2 and PDE10 inhibition affect auditory information processing in general, whereas PDE5 inhibition has no effect. These findings suggest that the positive effects of PDE5 inhibition on cognition previously found in animals are possibly the results of an effect on higher cognitive functioning specifically, whereas the cognition enhancing effects of PDE2 and PDE10 inhibition might also be influenced by effects on earlier stages of information processing.

KW - Sensory gating

KW - PDE2

KW - PDE5

KW - PDE10

KW - Auditory information processing

KW - Schizophrenia

KW - SELECTIVE PHOSPHODIESTERASE INHIBITORS

KW - SENSORY-GATING DEFICIT

KW - RECOGNITION MEMORY

KW - ALZHEIMERS-DISEASE

KW - NUCLEOTIDE PHOSPHODIESTERASE

KW - PREPULSE INHIBITION

KW - LEARNING IMPAIRMENT

KW - EVOKED POTENTIALS

KW - OBJECT MEMORY

KW - SINGLE-UNIT

U2 - 10.1016/j.bbr.2013.05.014

DO - 10.1016/j.bbr.2013.05.014

M3 - Article

VL - 250

SP - 251

EP - 256

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -