Patients with type 2 diabetes show a greater decline in muscle mass, muscle strength, and functional capacity with aging.

M. Leenders, L.B. Verdijk, L. van der Hoeven, J.J.M.E. Adam, J. van Kranenburg, R. Nilwik, L.J.C. van Loon*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: The loss of muscle mass with aging reduces muscle strength, functional capacity, and increases the risk of developing chronic disease. It has been suggested that the development of type 2 diabetes a more rapid decline in muscle mass, strength, and functional capacity. OBJECTIVE: To investigate the impact of type 2 diabetes on muscle mass, and functional capacity in an older population. METHODS: Muscle mass muscle biopsies), strength (1-repetition maximum), functional capacity (sit-to-stand test and handgrip strength), and reaction time performance (computer task) were compared between 60 older men with type 2 diabetes years) and 32 age-matched normoglycemic controls (70 +/- 1 years). Data analyzed using ANCOVA to adjust for several potential confounders. lean mass and appendicular skeletal muscle mass were significantly lower men with type 2 diabetes (19.1 +/- 0.3 and 25.9 +/- 0.4 kg, compared with normoglycemic controls (19.7 +/- 0.3 and 26.7 +/- 0.5 kg, respectively). Additionally, leg extension strength was significantly the group with type 2 diabetes (84 +/- 2 vs 91 +/- 2 kg, respectively). agreement, functional performance was impaired in the men with type 2 with longer sit-to-stand time (9.1 +/- 0.4 vs 7.8 +/- 0.3 seconds) and handgrip strength (39.5 +/- 5.8 vs 44.6 +/- 6.1 kg) when compared with normoglycemic controls. However, muscle fiber size and reaction time did not differ between groups. CONCLUSION: Older patients with type 2 show an accelerated decline in leg lean mass, muscle strength, and capacity when compared with normoglycemic controls. Exercise programs should be individualized to specifically target muscle mass, and functional capacity in the older population with type 2 diabetes.
Original languageEnglish
Pages (from-to)585-592
JournalJournal of the American Medical Directors Association
Issue number8
Publication statusPublished - 1 Jan 2013

Cite this