Patient-Derived Cancer Organoids as Predictors of Treatment Response

M. Verduin*, A. Hoeben, D. De Ruysscher, M. Vooijs

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

13 Citations (Web of Science)

Abstract

Patient-derived cancer organoids have taken a prominent role in pre-clinical and translational research and have been generated for most common solid tumors. Cancer organoids have been shown to retain key genetic and phenotypic characteristics of their tissue of origin, tumor subtype and maintain intratumoral heterogeneity and therefore have the potential to be used as predictors for individualized treatment response. In this review, we highlight studies that have used cancer organoids to compare the efficacy of standard-of-care and targeted combination treatments with clinical patient response. Furthermore, we review studies using cancer organoids to identify new anti-cancer treatments using drug screening. Finally, we discuss the current limitations and improvements needed to understand the full potential of cancer organoids as avatars for clinical management of cancer therapy.
Original languageEnglish
Article number641980
Number of pages16
JournalFrontiers in Oncology
Volume11
DOIs
Publication statusPublished - 18 Mar 2021

Keywords

  • organoids
  • precision medicine
  • treatment response
  • treatment prediction
  • cancer
  • patient-derived

Cite this