Patient- and tumor-related predictors of chemotherapy intolerance in older patients with cancer: A systematic review

Doris L. van Abbema, Marjan van den Akker, Maryska L. Janssen-Heijnen, Franchette van den Berkmortel, Ann Hoeben, Judith de Vos-Geelen, Frank Buntinx, Jos Kleijnen, Vivianne C. G. Tjan-Heijnen*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

23 Citations (Web of Science)

Abstract

Objective: The aim of this systematic review was to investigate patient-related factors (e.g. depressive symptoms, cognition, mobility, activities of daily living (ADL)) as well as tumor-related factors (e.g. tumor type, chemotherapy regimen) influencing chemotherapy intolerance in cancer patients aged 65 years or older.

Methods: We included observational studies that reported data on possible predictors of chemotherapy intolerance in older patients with cancer. We studied chemotherapy intolerance using the following outcomes: chemotherapy toxicity grade 3 to 5, unplanned hospitalization, chemotherapy discontinuation, chemotherapy dose reduction, functional decline, and chemotherapy mortality. We searched PubMed, Embase, and PsycInfo for articles between January 1995 and July 2016. The quality of the included studies was assessed using the Quality in Prognosis Studies (QUIPS) tool.

Results: The search yielded 1774 articles, and 30 articles from 27 studies were included. The patient-related factors associated with chemotherapy intolerance, in terms of the size of the association and the consistency of the results, were more than one fall in the last six months, mobility problems, poor performance status and the presence of severe comorbid conditions. The tumor-related factors that were associated with chemotherapy intolerance in older patients with cancer were certain regimens of chemotherapy and polychemotherapy, as compared to monochemotherapy. The number of studies on unplanned hospitalization and functional decline was small.

Conclusion: The included studies were heterogeneous with respect to endpoints and included parameters. Nevertheless, the size of the association and the consistency of results suggest that all these factors are relevant for everyday oncological practice. (C) 2018 The Authors. Published by Elsevier Ltd.

Original languageEnglish
Pages (from-to)31-41
Number of pages11
JournalJournal of Geriatric Oncology
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 2019

Keywords

  • Chemotherapy intolance
  • Chemotherapy toxicity
  • Older patients
  • Cancer
  • Geriatric oncology
  • Geriatric assessment
  • COMPREHENSIVE GERIATRIC ASSESSMENT
  • QUALITY-OF-LIFE
  • ELDERLY-PATIENTS
  • ADJUVANT CHEMOTHERAPY
  • COLORECTAL-CANCER
  • 1ST-LINE CHEMOTHERAPY
  • TREATMENT PATTERNS
  • IMPROVED SURVIVAL
  • FUNCTIONAL STATUS
  • DOSE-INTENSITY

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