TY - JOUR
T1 - Patient- and tumor-related predictors of chemotherapy intolerance in older patients with cancer
T2 - A systematic review
AU - van Abbema, Doris L.
AU - van den Akker, Marjan
AU - Janssen-Heijnen, Maryska L.
AU - van den Berkmortel, Franchette
AU - Hoeben, Ann
AU - de Vos-Geelen, Judith
AU - Buntinx, Frank
AU - Kleijnen, Jos
AU - Tjan-Heijnen, Vivianne C. G.
N1 - Funding Information:
This work was supported by the European Union/Interreg IV Grensregio Vlaanderen - Nederland [IVA-VLANED-3.46].
Funding Information:
This work was supported by the European Union/Interreg IV Grensregio Vlaanderen - Nederland [ IVA-VLANED-3.46 ].
Publisher Copyright:
© 2018 The Authors
PY - 2019/1
Y1 - 2019/1
N2 - Objective: The aim of this systematic review was to investigate patient-related factors (e.g. depressive symptoms, cognition, mobility, activities of daily living (ADL)) as well as tumor-related factors (e.g. tumor type, chemotherapy regimen) influencing chemotherapy intolerance in cancer patients aged 65 years or older.Methods: We included observational studies that reported data on possible predictors of chemotherapy intolerance in older patients with cancer. We studied chemotherapy intolerance using the following outcomes: chemotherapy toxicity grade 3 to 5, unplanned hospitalization, chemotherapy discontinuation, chemotherapy dose reduction, functional decline, and chemotherapy mortality. We searched PubMed, Embase, and PsycInfo for articles between January 1995 and July 2016. The quality of the included studies was assessed using the Quality in Prognosis Studies (QUIPS) tool.Results: The search yielded 1774 articles, and 30 articles from 27 studies were included. The patient-related factors associated with chemotherapy intolerance, in terms of the size of the association and the consistency of the results, were more than one fall in the last six months, mobility problems, poor performance status and the presence of severe comorbid conditions. The tumor-related factors that were associated with chemotherapy intolerance in older patients with cancer were certain regimens of chemotherapy and polychemotherapy, as compared to monochemotherapy. The number of studies on unplanned hospitalization and functional decline was small.Conclusion: The included studies were heterogeneous with respect to endpoints and included parameters. Nevertheless, the size of the association and the consistency of results suggest that all these factors are relevant for everyday oncological practice. (C) 2018 The Authors. Published by Elsevier Ltd.
AB - Objective: The aim of this systematic review was to investigate patient-related factors (e.g. depressive symptoms, cognition, mobility, activities of daily living (ADL)) as well as tumor-related factors (e.g. tumor type, chemotherapy regimen) influencing chemotherapy intolerance in cancer patients aged 65 years or older.Methods: We included observational studies that reported data on possible predictors of chemotherapy intolerance in older patients with cancer. We studied chemotherapy intolerance using the following outcomes: chemotherapy toxicity grade 3 to 5, unplanned hospitalization, chemotherapy discontinuation, chemotherapy dose reduction, functional decline, and chemotherapy mortality. We searched PubMed, Embase, and PsycInfo for articles between January 1995 and July 2016. The quality of the included studies was assessed using the Quality in Prognosis Studies (QUIPS) tool.Results: The search yielded 1774 articles, and 30 articles from 27 studies were included. The patient-related factors associated with chemotherapy intolerance, in terms of the size of the association and the consistency of the results, were more than one fall in the last six months, mobility problems, poor performance status and the presence of severe comorbid conditions. The tumor-related factors that were associated with chemotherapy intolerance in older patients with cancer were certain regimens of chemotherapy and polychemotherapy, as compared to monochemotherapy. The number of studies on unplanned hospitalization and functional decline was small.Conclusion: The included studies were heterogeneous with respect to endpoints and included parameters. Nevertheless, the size of the association and the consistency of results suggest that all these factors are relevant for everyday oncological practice. (C) 2018 The Authors. Published by Elsevier Ltd.
KW - Chemotherapy intolance
KW - Chemotherapy toxicity
KW - Older patients
KW - Cancer
KW - Geriatric oncology
KW - Geriatric assessment
KW - COMPREHENSIVE GERIATRIC ASSESSMENT
KW - QUALITY-OF-LIFE
KW - ELDERLY-PATIENTS
KW - ADJUVANT CHEMOTHERAPY
KW - COLORECTAL-CANCER
KW - 1ST-LINE CHEMOTHERAPY
KW - TREATMENT PATTERNS
KW - IMPROVED SURVIVAL
KW - FUNCTIONAL STATUS
KW - DOSE-INTENSITY
U2 - 10.1016/j.jgo.2018.04.001
DO - 10.1016/j.jgo.2018.04.001
M3 - (Systematic) Review article
C2 - 29706424
SN - 1879-4068
VL - 10
SP - 31
EP - 41
JO - Journal of Geriatric Oncology
JF - Journal of Geriatric Oncology
IS - 1
ER -