Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy

E. V. Udut; P. P. Shchetinin; T. V. Rudenko; F. Lucieer; H. Kingma; A. P. Shchetinina; M. O. Pleshkov; V. P. Demkin; V. V. Udut

doi:10.1007/s10517-018-4067-0

Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy

E. V. Udut^*, P. P. Shchetinin, T. V. Rudenko, F. Lucieer, H. Kingma, A. P. Shchetinina, M. O. Pleshkov, V. P. Demkin, V. V. Udut

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.

Original language	English
Pages (from-to)	726-729
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	164
Issue number	6
DOIs	https://doi.org/10.1007/s10517-018-4067-0
Publication status	Published - 1 Apr 2018

Keywords

bilateral vestibular hypofunction
vestibular tests
etiology
vertigo
endothelial dysfunction

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title = "Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy",

abstract = "Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.",

keywords = "bilateral vestibular hypofunction, vestibular tests, etiology, vertigo, endothelial dysfunction",

author = "Udut, {E. V.} and Shchetinin, {P. P.} and Rudenko, {T. V.} and F. Lucieer and H. Kingma and Shchetinina, {A. P.} and Pleshkov, {M. O.} and Demkin, {V. P.} and Udut, {V. V.}",

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doi = "10.1007/s10517-018-4067-0",

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T1 - Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy

AU - Udut, E. V.

AU - Shchetinin, P. P.

AU - Rudenko, T. V.

AU - Lucieer, F.

AU - Kingma, H.

AU - Shchetinina, A. P.

AU - Pleshkov, M. O.

AU - Demkin, V. P.

AU - Udut, V. V.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.

AB - Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.

KW - bilateral vestibular hypofunction

KW - vestibular tests

KW - etiology

KW - vertigo

KW - endothelial dysfunction

U2 - 10.1007/s10517-018-4067-0

DO - 10.1007/s10517-018-4067-0

M3 - Article

C2 - 29658088

SN - 0007-4888

VL - 164

SP - 726

EP - 729

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

IS - 6

ER -

Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy

Abstract

Keywords

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