Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy

E. V. Udut*, P. P. Shchetinin, T. V. Rudenko, F. Lucieer, H. Kingma, A. P. Shchetinina, M. O. Pleshkov, V. P. Demkin, V. V. Udut

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.
Original languageEnglish
Pages (from-to)726-729
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Issue number6
Publication statusPublished - 1 Apr 2018


  • bilateral vestibular hypofunction
  • vestibular tests
  • etiology
  • vertigo
  • endothelial dysfunction


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