Paternal exposure to benzo(a)pyrene : a genetic risk in offspring?

N. Verhofstad

    Research output: ThesisDoctoral ThesisInternal

    225 Downloads (Pure)

    Abstract

    Each day we are exposed to substances that are dangerous for the environment that influence our health and possibly the health of our offspring. Benzo(a)pyrene, for example, is formed by the combustion of organic materials, such as wood, diesel and tobacco. Research has already shown that benzo(a)pyrene can cause DNA mutations and consequently cancer. This dissertation describes the DNA-damaging effects of benzo(a)pyrene in testes and male reproductive cells of mice and shows that benzo(a)pyrene can cause germinal line mutations in spermatogonial stem cells of mice. Transferral of these mutations on the offspring may increase the risk of diseases, such as cancer, at a young age. Future research will have to show whether benzo(a)pyrene causes germinal line mutations in humans.

    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Maastricht University
    Supervisors/Advisors
    • van Schooten, Frederik, Supervisor
    • van Steeg, H., Supervisor, External person
    • Godschalk, Roger, Advisor
    Award date21 Dec 2010
    Place of PublicationMaastricht
    Publisher
    Publication statusPublished - 1 Jan 2010

    Keywords

    • benzo(a)pyrene
    • DNA damage
    • mutations
    • germinal line

    Cite this

    Verhofstad, N. (2010). Paternal exposure to benzo(a)pyrene : a genetic risk in offspring?. Datawyse / Universitaire Pers Maastricht.