Patent Foramen Ovale and Cryptogenic Stroke: Integrated Management

F. Luca; P.G. Pino; I. Parrini; S.A. Di Fusco; R. Ceravolo; A. Madeo; A. Leone; M. La Mair; F.A. Benedetto; C. Riccio; F. Oliva; F. Colivicchi; M.M. Gulizia; S. Gelsomino

doi:10.3390/jcm12051952

Patent Foramen Ovale and Cryptogenic Stroke: Integrated Management

F. Luca^*, P.G. Pino, I. Parrini, S.A. Di Fusco, R. Ceravolo, A. Madeo, A. Leone, M. La Mair, F.A. Benedetto, C. Riccio, F. Oliva, F. Colivicchi, M.M. Gulizia, S. Gelsomino^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Patent foramen ovale (PFO) is a common cardiac abnormality with a prevalence of 25% in the general population. PFO has been associated with the paradoxical embolism causing cryptogenic stroke and systemic embolization. Results from clinical trials, meta-analyses, and position papers support percutaneous PFO device closure (PPFOC), especially if interatrial septal aneurysms coexist and in the presence of large shunts in young patients. Remarkably, accurately evaluating patients to refer to the closure strategy is extremely important. However, the selection of patients for PFO closure is still not so clear. The aim of this review is to update and clarify which patients should be considered for closure treatment.

Original language	English
Article number	1952
Number of pages	15
Journal	Journal of Clinical Medicine
Volume	12
Issue number	5
DOIs	https://doi.org/10.3390/jcm12051952
Publication status	Published - 1 Mar 2023

Keywords

Patent foramen ovale (PFO)
device closure
interatrial septal aneurysms
PFO-associated syndromes
cryptogenic stroke
TO-LEFT SHUNT
ATRIAL-FIBRILLATION DETECTION
ACUTE ISCHEMIC-STROKE
PERCUTANEOUS CLOSURE
TRANSCATHETER CLOSURE
TRANSCRANIAL DOPPLER
MEDICAL THERAPY
PFO CLOSURE
TRANSTHORACIC ECHOCARDIOGRAPHY
SECONDARY PREVENTION

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title = "Patent Foramen Ovale and Cryptogenic Stroke: Integrated Management",

abstract = "Patent foramen ovale (PFO) is a common cardiac abnormality with a prevalence of 25% in the general population. PFO has been associated with the paradoxical embolism causing cryptogenic stroke and systemic embolization. Results from clinical trials, meta-analyses, and position papers support percutaneous PFO device closure (PPFOC), especially if interatrial septal aneurysms coexist and in the presence of large shunts in young patients. Remarkably, accurately evaluating patients to refer to the closure strategy is extremely important. However, the selection of patients for PFO closure is still not so clear. The aim of this review is to update and clarify which patients should be considered for closure treatment.",

keywords = "Patent foramen ovale (PFO), device closure, interatrial septal aneurysms, PFO-associated syndromes, cryptogenic stroke, TO-LEFT SHUNT, ATRIAL-FIBRILLATION DETECTION, ACUTE ISCHEMIC-STROKE, PERCUTANEOUS CLOSURE, TRANSCATHETER CLOSURE, TRANSCRANIAL DOPPLER, MEDICAL THERAPY, PFO CLOSURE, TRANSTHORACIC ECHOCARDIOGRAPHY, SECONDARY PREVENTION",

author = "F. Luca and P.G. Pino and I. Parrini and {Di Fusco}, S.A. and R. Ceravolo and A. Madeo and A. Leone and {La Mair}, M. and F.A. Benedetto and C. Riccio and F. Oliva and F. Colivicchi and M.M. Gulizia and S. Gelsomino",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = mar,

day = "1",

doi = "10.3390/jcm12051952",

language = "English",

volume = "12",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Patent Foramen Ovale and Cryptogenic Stroke: Integrated Management

AU - Luca, F.

AU - Pino, P.G.

AU - Parrini, I.

AU - Di Fusco, S.A.

AU - Ceravolo, R.

AU - Madeo, A.

AU - Leone, A.

AU - La Mair, M.

AU - Benedetto, F.A.

AU - Riccio, C.

AU - Oliva, F.

AU - Colivicchi, F.

AU - Gulizia, M.M.

AU - Gelsomino, S.

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Patent foramen ovale (PFO) is a common cardiac abnormality with a prevalence of 25% in the general population. PFO has been associated with the paradoxical embolism causing cryptogenic stroke and systemic embolization. Results from clinical trials, meta-analyses, and position papers support percutaneous PFO device closure (PPFOC), especially if interatrial septal aneurysms coexist and in the presence of large shunts in young patients. Remarkably, accurately evaluating patients to refer to the closure strategy is extremely important. However, the selection of patients for PFO closure is still not so clear. The aim of this review is to update and clarify which patients should be considered for closure treatment.

AB - Patent foramen ovale (PFO) is a common cardiac abnormality with a prevalence of 25% in the general population. PFO has been associated with the paradoxical embolism causing cryptogenic stroke and systemic embolization. Results from clinical trials, meta-analyses, and position papers support percutaneous PFO device closure (PPFOC), especially if interatrial septal aneurysms coexist and in the presence of large shunts in young patients. Remarkably, accurately evaluating patients to refer to the closure strategy is extremely important. However, the selection of patients for PFO closure is still not so clear. The aim of this review is to update and clarify which patients should be considered for closure treatment.

KW - Patent foramen ovale (PFO)

KW - device closure

KW - interatrial septal aneurysms

KW - PFO-associated syndromes

KW - cryptogenic stroke

KW - TO-LEFT SHUNT

KW - ATRIAL-FIBRILLATION DETECTION

KW - ACUTE ISCHEMIC-STROKE

KW - PERCUTANEOUS CLOSURE

KW - TRANSCATHETER CLOSURE

KW - TRANSCRANIAL DOPPLER

KW - MEDICAL THERAPY

KW - PFO CLOSURE

KW - TRANSTHORACIC ECHOCARDIOGRAPHY

KW - SECONDARY PREVENTION

U2 - 10.3390/jcm12051952

DO - 10.3390/jcm12051952

M3 - (Systematic) Review article

C2 - 36902748

SN - 2077-0383

VL - 12

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 5

M1 - 1952

ER -

Patent Foramen Ovale and Cryptogenic Stroke: Integrated Management

Abstract

Keywords

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