Parent-of-origin-specific signatures of de novo mutations

Jakob M. Goldmann, Wendy S. W. Wong, Michele Pinelli, Terry Farrah, Dale Bodian, Anna B. Stittrich, Gustavo Glusman, Lisenka E. L. M. Vissers, Alexander Hoischen, Jared C. Roach, Joseph G. Vockley, Joris A. Veltman, Benjamin D. Solomon, Christian Gilissen*, John E. Niederhuber*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


De novo mutations (DNMs) originating in gametogenesis are an important source of genetic variation. We use a data set of 7,216 autosomal DNMs with resolved parent of origin from whole-genome sequencing of 816 parent-offspring trios to investigate differences between maternally and paternally derived DNMs and study the underlying mutational mechanisms. Our results show that the number of DNMs in offspring increases not only with paternal age, but also with maternal age, and that some genome regions show enrichment for maternally derived DNMs. We identify parent-of-origin-specific mutation signatures that become more pronounced with increased parental age, pointing to different mutational mechanisms in spermatogenesis and oogenesis. Moreover, we find DNMs that are spatially clustered to have a unique mutational signature with no significant differences between parental alleles, suggesting a different mutational mechanism. Our findings provide insights into the molecular mechanisms that underlie mutagenesis and are relevant to disease and evolution in humans(1).
Original languageEnglish
Pages (from-to)935–939
JournalNature Genetics
Issue number8
Publication statusPublished - Aug 2016


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  • Erratum to: Parent-of-origin-specific signatures of de novo mutations

    Goldmann, J. M., Wong, W. S. W., Pinelli, M., Farrah, T., Bodian, D., Stittrich, A. B., Glusman, G., Vissers, L. E. L. M., Hoischen, A., Roach, J. C., Vockley, J. G., Veltman, J. A., Solomon, B. D., Gilissen, C. & Niederhuber, J. E., 1 Nov 2018, In: Nature Genetics. 50, 11, p. 1615

    Research output: Contribution to journalErratum / corrigendum / retractionsAcademic

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