TY - JOUR
T1 - Parelsnoer institute biobank hereditary colorectal cancer
T2 - A joint infrastructure for patient data and biomaterial on hereditary colorectal cancer in the Netherlands
AU - Manders, Peggy
AU - Vos, Janet R.
AU - De Voer, Richarda M.
AU - Van Hest, Liselot P.
AU - Sijmons, Rolf
AU - Hoge, Chantal V.
AU - Terpstra, Fokke G.
AU - Spaander, Manon C.
AU - Mesker, Wilma E.
AU - Dekker, Evelien
AU - Hoogerbrugge, Nicoline
N1 - Funding Information:
Each year approximately 15,000 patients are diagnosed with colorectal cancer (CRC) in the Netherlands, of whom 5–10% are associated with a hereditary syndrome. To enable future research into hereditary CRC, we established a collaborative biobank for hereditary CRC in all eight University Medical Centers (UMCs) in the Netherlands in 2009. This Biobank Hereditary CRC is part of the Parelsnoer Institute (PSI), which is funded by the Dutch Federation of UMCs and the Dutch Government. Besides the multicenter collaboration, the multidisciplinary nature of this biobank – involving Gastroenterology, Genetics and Surgery – is essential for its functionality and value.
Publisher Copyright:
© 2019 Ubiquity Press. All Rights Reserved.
PY - 2019/4/25
Y1 - 2019/4/25
N2 - Each year approximately 15,000 patients are diagnosed with colorectal cancer (CRC) in the Netherlands, of whom 5-10% are associated with a hereditary syndrome. To enable future research into hereditary CRC, we established a collaborative biobank for hereditary CRC in all eight University Medical Centers (UMCs) in the Netherlands in 2009. This Biobank Hereditary CRC is part of the Parelsnoer Institute (PSI), which is funded by the Dutch Federation of UMCs and the Dutch Government. Besides the multicenter collaboration, the multidisciplinary nature of this biobank - involving Gastroenterology, Genetics and Surgery - is essential for its functionality and value.Patients at increased risk of hereditary CRC and/or Polyposis, or with a proven germline mutation causing CRC and/or Polyposis are included. Both clinical data (demographic data, details on medical and family history, information on surveillance, endoscopy and surgery, results of microsatellite instability and molecular genetic tests) and biomaterial (DNA, plasma, serum and tissue) are collected in a standardized manner.
AB - Each year approximately 15,000 patients are diagnosed with colorectal cancer (CRC) in the Netherlands, of whom 5-10% are associated with a hereditary syndrome. To enable future research into hereditary CRC, we established a collaborative biobank for hereditary CRC in all eight University Medical Centers (UMCs) in the Netherlands in 2009. This Biobank Hereditary CRC is part of the Parelsnoer Institute (PSI), which is funded by the Dutch Federation of UMCs and the Dutch Government. Besides the multicenter collaboration, the multidisciplinary nature of this biobank - involving Gastroenterology, Genetics and Surgery - is essential for its functionality and value.Patients at increased risk of hereditary CRC and/or Polyposis, or with a proven germline mutation causing CRC and/or Polyposis are included. Both clinical data (demographic data, details on medical and family history, information on surveillance, endoscopy and surgery, results of microsatellite instability and molecular genetic tests) and biomaterial (DNA, plasma, serum and tissue) are collected in a standardized manner.
KW - Clinical biobanking
KW - Harmonized standards
KW - hereditary colorectal cancer
KW - Parelsnoer Institute
KW - Research standards
U2 - 10.5334/ojb.54
DO - 10.5334/ojb.54
M3 - Article
SN - 2056-5542
VL - 6
JO - Open Journal of Bioresources
JF - Open Journal of Bioresources
M1 - 1
ER -