Parallels between the Developing Vascular and Neural Systems: Signaling Pathways and Future Perspectives for Regenerative Medicine

I.E. Ridaura, S. Sorrentino, L. Moroni*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Neurovascular disorders, which involve the vascular and nervous systems, are common. Research on such disorders usually focuses on either vascular or nervous components, without looking at how they interact. Adopting a neurovascular perspective is essential to improve current treatments. Therefore, comparing molecular processes known to be involved in both systems separately can provide insight into promising areas of future research. Since development and regeneration share many mechanisms, comparing signaling molecules involved in both the developing vascular and nervous systems and shedding light to those that they have in common can reveal processes, which have not yet been studied from a regenerative perspective, yet hold great potential. Hence, this review discusses and compares processes involved in the development of the vascular and nervous systems, in order to provide an overview of the molecular mechanisms, which are most promising with regards to treatment for neurovascular disorders. Vascular endothelial growth factor, semaphorins, and ephrins are found to hold the most potential, while fibroblast growth factor, bone morphogenic protein, slits, and sonic hedgehog are shown to participate in both the developing vascular and nervous systems, yet have not been studied at the neurovascular level, therefore being of special interest for future research.
Original languageEnglish
Article number2101837
Number of pages34
JournalAdvanced Science
Volume8
Issue number23
Early online date24 Oct 2021
DOIs
Publication statusPublished - Dec 2021

Keywords

  • AUTOLOGOUS TRANSPLANTATION
  • AXON OUTGROWTH
  • BLOOD-BRAIN-BARRIER
  • ENDOTHELIAL-CELLS
  • ISCHEMIC-STROKE
  • MONONUCLEAR-CELLS
  • NERVE GROWTH-FACTOR
  • NEUROTROPHIC FACTOR
  • RETINOIC ACID
  • STEM-CELL THERAPY
  • growth cone
  • neural stem cells
  • neurovascular unit
  • stem cell therapy
  • tip cells

Cite this