Paraganglion, a pitfall in diagnosis after regular cholecystectomy

Bartholomeus J. G. A. Corten*, Wouter K. G. Leclercq, M. Wouter Dercksen, Wilhelmus T. van den Broek, Peter H. van Zwam, Cees H. Dejong, Gerrit D. Slooter

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


INTRODUCTION: Neuroendocrine neoplasm of the gallbladder is an extremely uncommon diagnosis. We present a case of a benign gallbladder paraganglion that was initially incorrectly diagnosed as a neuroendocrine tumour (NET).

PRESENTATION OF CASE: A 27-year-old female with symptomatic gallstone disease underwent an uncomplicated laparoscopic cholecystectomy. Routine histopathologic examination suggested the presence of a small adventitial NET. However, histopathological revision was performed by our pathologist because of regional gallbladder carcinoma (GBC) treatment evaluation. The revision demonstrated the presence of a normal paraganglion, a preexistent structure that is only rarely encountered during routine histopathologic examination of the gallbladder.

DISCUSSION: Neuroendocrine neoplasms of the gallbladder are extremely rare. Treatment varies from a simple cholecystectomy to extensive surgical resections. Chemotherapy is usually reserved for metastatic disease. In contrast, a gallbladder paraganglion is a benign entity not requiring additional treatment.

CONCLUSION: A neuroendocrine neoplasm of the gallbladder may closely resemble a benign paraganglion. If a NET is suspected, the clinician should be aware of the histopathologic mimicry of a paraganglion prior to initiating additional treatments. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalInternational Journal of Surgery Case Reports
Publication statusPublished - 2019


  • Gallbladder cancer
  • Neuroendocrine neoplasm
  • Neuroendocrine tumour
  • Paraganglion

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