Paraganglion, a pitfall in diagnosis after regular cholecystectomy

Bartholomeus J. G. A. Corten; Wouter K. G. Leclercq; M. Wouter Dercksen; Wilhelmus T. van den Broek; Peter H. van Zwam; Cees H. Dejong; Gerrit D. Slooter

doi:10.1016/j.ijscr.2019.10.042

Paraganglion, a pitfall in diagnosis after regular cholecystectomy

Bartholomeus J. G. A. Corten^*, Wouter K. G. Leclercq, M. Wouter Dercksen, Wilhelmus T. van den Broek, Peter H. van Zwam, Cees H. Dejong, Gerrit D. Slooter

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: Neuroendocrine neoplasm of the gallbladder is an extremely uncommon diagnosis. We present a case of a benign gallbladder paraganglion that was initially incorrectly diagnosed as a neuroendocrine tumour (NET).

PRESENTATION OF CASE: A 27-year-old female with symptomatic gallstone disease underwent an uncomplicated laparoscopic cholecystectomy. Routine histopathologic examination suggested the presence of a small adventitial NET. However, histopathological revision was performed by our pathologist because of regional gallbladder carcinoma (GBC) treatment evaluation. The revision demonstrated the presence of a normal paraganglion, a preexistent structure that is only rarely encountered during routine histopathologic examination of the gallbladder.

DISCUSSION: Neuroendocrine neoplasms of the gallbladder are extremely rare. Treatment varies from a simple cholecystectomy to extensive surgical resections. Chemotherapy is usually reserved for metastatic disease. In contrast, a gallbladder paraganglion is a benign entity not requiring additional treatment.

CONCLUSION: A neuroendocrine neoplasm of the gallbladder may closely resemble a benign paraganglion. If a NET is suspected, the clinician should be aware of the histopathologic mimicry of a paraganglion prior to initiating additional treatments. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.

Original language	English
Pages (from-to)	205-208
Number of pages	4
Journal	International Journal of Surgery Case Reports
Volume	65
DOIs	https://doi.org/10.1016/j.ijscr.2019.10.042
Publication status	Published - 2019

Keywords

Gallbladder cancer
Neuroendocrine neoplasm
Neuroendocrine tumour
Paraganglion
NEUROENDOCRINE TUMORS
CARCINOID-TUMOR
GALLBLADDER

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Cite this

@article{7f644cc4e252404bbb2a23bca97739af,

title = "Paraganglion, a pitfall in diagnosis after regular cholecystectomy",

abstract = "INTRODUCTION: Neuroendocrine neoplasm of the gallbladder is an extremely uncommon diagnosis. We present a case of a benign gallbladder paraganglion that was initially incorrectly diagnosed as a neuroendocrine tumour (NET).PRESENTATION OF CASE: A 27-year-old female with symptomatic gallstone disease underwent an uncomplicated laparoscopic cholecystectomy. Routine histopathologic examination suggested the presence of a small adventitial NET. However, histopathological revision was performed by our pathologist because of regional gallbladder carcinoma (GBC) treatment evaluation. The revision demonstrated the presence of a normal paraganglion, a preexistent structure that is only rarely encountered during routine histopathologic examination of the gallbladder.DISCUSSION: Neuroendocrine neoplasms of the gallbladder are extremely rare. Treatment varies from a simple cholecystectomy to extensive surgical resections. Chemotherapy is usually reserved for metastatic disease. In contrast, a gallbladder paraganglion is a benign entity not requiring additional treatment.CONCLUSION: A neuroendocrine neoplasm of the gallbladder may closely resemble a benign paraganglion. If a NET is suspected, the clinician should be aware of the histopathologic mimicry of a paraganglion prior to initiating additional treatments. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.",

keywords = "Gallbladder cancer, Neuroendocrine neoplasm, Neuroendocrine tumour, Paraganglion, NEUROENDOCRINE TUMORS, CARCINOID-TUMOR, GALLBLADDER",

author = "Corten, {Bartholomeus J. G. A.} and Leclercq, {Wouter K. G.} and Dercksen, {M. Wouter} and {van den Broek}, {Wilhelmus T.} and {van Zwam}, {Peter H.} and Dejong, {Cees H.} and Slooter, {Gerrit D.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

doi = "10.1016/j.ijscr.2019.10.042",

language = "English",

volume = "65",

pages = "205--208",

journal = "International Journal of Surgery Case Reports",

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T1 - Paraganglion, a pitfall in diagnosis after regular cholecystectomy

AU - Corten, Bartholomeus J. G. A.

AU - Leclercq, Wouter K. G.

AU - Dercksen, M. Wouter

AU - van den Broek, Wilhelmus T.

AU - van Zwam, Peter H.

AU - Dejong, Cees H.

AU - Slooter, Gerrit D.

PY - 2019

Y1 - 2019

N2 - INTRODUCTION: Neuroendocrine neoplasm of the gallbladder is an extremely uncommon diagnosis. We present a case of a benign gallbladder paraganglion that was initially incorrectly diagnosed as a neuroendocrine tumour (NET).PRESENTATION OF CASE: A 27-year-old female with symptomatic gallstone disease underwent an uncomplicated laparoscopic cholecystectomy. Routine histopathologic examination suggested the presence of a small adventitial NET. However, histopathological revision was performed by our pathologist because of regional gallbladder carcinoma (GBC) treatment evaluation. The revision demonstrated the presence of a normal paraganglion, a preexistent structure that is only rarely encountered during routine histopathologic examination of the gallbladder.DISCUSSION: Neuroendocrine neoplasms of the gallbladder are extremely rare. Treatment varies from a simple cholecystectomy to extensive surgical resections. Chemotherapy is usually reserved for metastatic disease. In contrast, a gallbladder paraganglion is a benign entity not requiring additional treatment.CONCLUSION: A neuroendocrine neoplasm of the gallbladder may closely resemble a benign paraganglion. If a NET is suspected, the clinician should be aware of the histopathologic mimicry of a paraganglion prior to initiating additional treatments. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.

AB - INTRODUCTION: Neuroendocrine neoplasm of the gallbladder is an extremely uncommon diagnosis. We present a case of a benign gallbladder paraganglion that was initially incorrectly diagnosed as a neuroendocrine tumour (NET).PRESENTATION OF CASE: A 27-year-old female with symptomatic gallstone disease underwent an uncomplicated laparoscopic cholecystectomy. Routine histopathologic examination suggested the presence of a small adventitial NET. However, histopathological revision was performed by our pathologist because of regional gallbladder carcinoma (GBC) treatment evaluation. The revision demonstrated the presence of a normal paraganglion, a preexistent structure that is only rarely encountered during routine histopathologic examination of the gallbladder.DISCUSSION: Neuroendocrine neoplasms of the gallbladder are extremely rare. Treatment varies from a simple cholecystectomy to extensive surgical resections. Chemotherapy is usually reserved for metastatic disease. In contrast, a gallbladder paraganglion is a benign entity not requiring additional treatment.CONCLUSION: A neuroendocrine neoplasm of the gallbladder may closely resemble a benign paraganglion. If a NET is suspected, the clinician should be aware of the histopathologic mimicry of a paraganglion prior to initiating additional treatments. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.

KW - Gallbladder cancer

KW - Neuroendocrine neoplasm

KW - Neuroendocrine tumour

KW - Paraganglion

KW - NEUROENDOCRINE TUMORS

KW - CARCINOID-TUMOR

KW - GALLBLADDER

U2 - 10.1016/j.ijscr.2019.10.042

DO - 10.1016/j.ijscr.2019.10.042

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VL - 65

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EP - 208

JO - International Journal of Surgery Case Reports

JF - International Journal of Surgery Case Reports

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