Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model

Bert M. Verheijen, Jo A. A. Stevens, Romina J. G. Gentier, Christian D. van't Hekke, Daniel L. A. van den Hove, Denise J. H. P. Hermes, Harry W. M. Steinbusch, Jan M. Ruijter, Marcus O. W. Grimm, Viola J. Haupenthal, Wim Annaert, Tobias Hartmann, Fred W. van Leeuwen

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)62-71
Number of pages10
JournalNeurobiology of Aging
Volume72
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Mutant ubiquitin
  • Ubiquitin-proteasome system
  • gamma-Secretase
  • Amyloid-beta
  • Behavior Alzheimer's disease
  • AMYLOID PRECURSOR PROTEIN
  • GAMMA-SECRETASE ACTIVITY
  • PROTEASOME SYSTEM
  • IN-VIVO
  • NEURODEGENERATIVE DISEASES
  • PRESENILIN ENDOPROTEOLYSIS
  • BEHAVIORAL DEFICITS
  • ABERRANT UBIQUITIN
  • 26S PROTEASOME
  • ACCUMULATION
  • INHIBITION
  • DYSFUNCTION
  • GAMMA-SECRETASE
  • EXPRESSION

Cite this

Verheijen, B. M., Stevens, J. A. A., Gentier, R. J. G., van't Hekke, C. D., van den Hove, D. L. A., Hermes, D. J. H. P., Steinbusch, H. W. M., Ruijter, J. M., Grimm, M. O. W., Haupenthal, V. J., Annaert, W., Hartmann, T., & van Leeuwen, F. W. (2018). Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model. Neurobiology of Aging, 72, 62-71. https://doi.org/10.1016/j.neurobiolaging.2018.08.011