Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model

Bert M. Verheijen, Jo A. A. Stevens, Romina J. G. Gentier, Christian D. van't Hekke, Daniel L. A. van den Hove, Denise J. H. P. Hermes, Harry W. M. Steinbusch, Jan M. Ruijter, Marcus O. W. Grimm, Viola J. Haupenthal, Wim Annaert, Tobias Hartmann, Fred W. van Leeuwen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)
Original languageEnglish
Pages (from-to)62-71
Number of pages10
JournalNeurobiology of Aging
Volume72
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Mutant ubiquitin
  • Ubiquitin-proteasome system
  • gamma-Secretase
  • Amyloid-beta
  • Behavior Alzheimer's disease
  • AMYLOID PRECURSOR PROTEIN
  • GAMMA-SECRETASE ACTIVITY
  • PROTEASOME SYSTEM
  • IN-VIVO
  • NEURODEGENERATIVE DISEASES
  • PRESENILIN ENDOPROTEOLYSIS
  • BEHAVIORAL DEFICITS
  • ABERRANT UBIQUITIN
  • 26S PROTEASOME
  • ACCUMULATION
  • INHIBITION
  • DYSFUNCTION
  • GAMMA-SECRETASE
  • EXPRESSION

Cite this