Palmoplantar epidermal differentiation disorders: a new classification towards pathogenesis-based therapy

Eli Sprecher; Akemi Ishida-Yamamoto; Janice Schwartz; Masashi Akiyama; Mandy Aldwin-Easton; Keith Choate; Judith Fischer; Antoni Gostynski; Céline Granier Tournier; Angela Hernandez-Martin; Alain Hovnanian; Kiril Malovitski; Juliette Mazereeuw-Hautier; Amy S Paller; Matthias Schmuth; Gianluca Tadini; Joyce Teng; Christine Bodemer; Edel A O'Toole

doi:10.1093/bjd/ljaf054

Palmoplantar epidermal differentiation disorders: a new classification towards pathogenesis-based therapy

Eli Sprecher, Akemi Ishida-Yamamoto, Janice Schwartz, Masashi Akiyama, Mandy Aldwin-Easton, Keith Choate, Judith Fischer, Antoni Gostynski, Céline Granier Tournier, Angela Hernandez-Martin, Alain Hovnanian, Kiril Malovitski, Juliette Mazereeuw-Hautier, Amy S Paller, Matthias Schmuth, Gianluca Tadini, Joyce Teng, Christine Bodemer, Edel A O'Toole^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

More than 50 palmoplantar epidermal differentiation disorders (pEDDs) have been reported in the literature. Various descriptors have been used to name these conditions including clinical features often designated as acronyms or evocative terms, names of clinicians and of geographical locations. Not only has this nomenclature been criticized for its lack of methodological consistency, it has progressively lost its clinical relevance. Indeed, the advent of a wide range of pathogenesis-targeting therapeutic solutions for these disorders has raised the need for a novel classification of pEDDs, based on their causative genetic defects, to provide clinicians with genuine therapeutic guidance. Here, we present a novel classification scheme for pEDDs and its application in the form of a practical algorithm for the rapid diagnosis of pEDDs.

Original language	English
Journal	British Journal of Dermatology
DOIs	https://doi.org/10.1093/bjd/ljaf054
Publication status	E-pub ahead of print - 19 Mar 2025

Access to Document

10.1093/bjd/ljaf054

Cite this

Sprecher, E., Ishida-Yamamoto, A., Schwartz, J., Akiyama, M., Aldwin-Easton, M., Choate, K., Fischer, J., Gostynski, A., Granier Tournier, C., Hernandez-Martin, A., Hovnanian, A., Malovitski, K., Mazereeuw-Hautier, J., Paller, A. S., Schmuth, M., Tadini, G., Teng, J., Bodemer, C., & O'Toole, E. A. (2025). Palmoplantar epidermal differentiation disorders: a new classification towards pathogenesis-based therapy. British Journal of Dermatology. Advance online publication. https://doi.org/10.1093/bjd/ljaf054

@article{22bab2a510e141fbaa8cc4ef68e2fb9e,

title = "Palmoplantar epidermal differentiation disorders: a new classification towards pathogenesis-based therapy",

abstract = "More than 50 palmoplantar epidermal differentiation disorders (pEDDs) have been reported in the literature. Various descriptors have been used to name these conditions including clinical features often designated as acronyms or evocative terms, names of clinicians and of geographical locations. Not only has this nomenclature been criticized for its lack of methodological consistency, it has progressively lost its clinical relevance. Indeed, the advent of a wide range of pathogenesis-targeting therapeutic solutions for these disorders has raised the need for a novel classification of pEDDs, based on their causative genetic defects, to provide clinicians with genuine therapeutic guidance. Here, we present a novel classification scheme for pEDDs and its application in the form of a practical algorithm for the rapid diagnosis of pEDDs.",

author = "Eli Sprecher and Akemi Ishida-Yamamoto and Janice Schwartz and Masashi Akiyama and Mandy Aldwin-Easton and Keith Choate and Judith Fischer and Antoni Gostynski and \{Granier Tournier\}, C{\'e}line and Angela Hernandez-Martin and Alain Hovnanian and Kiril Malovitski and Juliette Mazereeuw-Hautier and Paller, \{Amy S\} and Matthias Schmuth and Gianluca Tadini and Joyce Teng and Christine Bodemer and O'Toole, \{Edel A\}",

year = "2025",

month = mar,

day = "19",

doi = "10.1093/bjd/ljaf054",

language = "English",

journal = "British Journal of Dermatology",

issn = "0007-0963",

publisher = "Oxford University Press",

}

Sprecher, E, Ishida-Yamamoto, A, Schwartz, J, Akiyama, M, Aldwin-Easton, M, Choate, K, Fischer, J, Gostynski, A, Granier Tournier, C, Hernandez-Martin, A, Hovnanian, A, Malovitski, K, Mazereeuw-Hautier, J, Paller, AS, Schmuth, M, Tadini, G, Teng, J, Bodemer, C & O'Toole, EA 2025, 'Palmoplantar epidermal differentiation disorders: a new classification towards pathogenesis-based therapy', British Journal of Dermatology. https://doi.org/10.1093/bjd/ljaf054

TY - JOUR

T1 - Palmoplantar epidermal differentiation disorders

T2 - a new classification towards pathogenesis-based therapy

AU - Sprecher, Eli

AU - Ishida-Yamamoto, Akemi

AU - Schwartz, Janice

AU - Akiyama, Masashi

AU - Aldwin-Easton, Mandy

AU - Choate, Keith

AU - Fischer, Judith

AU - Gostynski, Antoni

AU - Granier Tournier, Céline

AU - Hernandez-Martin, Angela

AU - Hovnanian, Alain

AU - Malovitski, Kiril

AU - Mazereeuw-Hautier, Juliette

AU - Paller, Amy S

AU - Schmuth, Matthias

AU - Tadini, Gianluca

AU - Teng, Joyce

AU - Bodemer, Christine

AU - O'Toole, Edel A

PY - 2025/3/19

Y1 - 2025/3/19

N2 - More than 50 palmoplantar epidermal differentiation disorders (pEDDs) have been reported in the literature. Various descriptors have been used to name these conditions including clinical features often designated as acronyms or evocative terms, names of clinicians and of geographical locations. Not only has this nomenclature been criticized for its lack of methodological consistency, it has progressively lost its clinical relevance. Indeed, the advent of a wide range of pathogenesis-targeting therapeutic solutions for these disorders has raised the need for a novel classification of pEDDs, based on their causative genetic defects, to provide clinicians with genuine therapeutic guidance. Here, we present a novel classification scheme for pEDDs and its application in the form of a practical algorithm for the rapid diagnosis of pEDDs.

AB - More than 50 palmoplantar epidermal differentiation disorders (pEDDs) have been reported in the literature. Various descriptors have been used to name these conditions including clinical features often designated as acronyms or evocative terms, names of clinicians and of geographical locations. Not only has this nomenclature been criticized for its lack of methodological consistency, it has progressively lost its clinical relevance. Indeed, the advent of a wide range of pathogenesis-targeting therapeutic solutions for these disorders has raised the need for a novel classification of pEDDs, based on their causative genetic defects, to provide clinicians with genuine therapeutic guidance. Here, we present a novel classification scheme for pEDDs and its application in the form of a practical algorithm for the rapid diagnosis of pEDDs.

U2 - 10.1093/bjd/ljaf054

DO - 10.1093/bjd/ljaf054

M3 - Article

SN - 0007-0963

JO - British Journal of Dermatology

JF - British Journal of Dermatology

ER -

Palmoplantar epidermal differentiation disorders: a new classification towards pathogenesis-based therapy

Abstract

Access to Document

Fingerprint

Cite this