Pain management after photorefractive keratectomy

Rohit Shetty; Ritika Dalal; Archana Padmanabhan Nair; Pooja Khamar; Sharon D'Souza; Ravish Vaishnav

doi:10.1016/j.jcrs.2019.01.032

Pain management after photorefractive keratectomy

Rohit Shetty, Ritika Dalal, Archana Padmanabhan Nair, Pooja Khamar, Sharon D'Souza^*, Ravish Vaishnav

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Web of Science)

Abstract

Purpose: To evaluate the effect of a bandage contact lens soaked in ketorolac ophthalmic 0.45% solution (Acuvail) on pain modulation in patients having transepithelial photorefractive keratectomy (PRK).

Design: Prospective case series.

Setting: Narayana Nethralaya Superspeciality Eye Hospital, Bangalore, India.

Methods: Eyes of patients were divided into 2 groups. After transepithelial PRK, a regular soft bandage contact lens was placed in Group 1 and a ketorolac-soaked bandage contact lens was placed in Group 2. The patients were matched for age and sex in the 2 groups. Postoperative pain was compared using the validated Wong-Baker pain scale. Before placement of a ketorolac-soaked bandage contact lens in patients' eyes, the safety of the procedure was checked using cultures from the bandage contact lens and measuring the quantity of the drug adsorbed and the elution profile over time with ultra-high-performance liquid chromatography (UHPLC).

Results: Each group comprised 35 eyes of 35 patients. The mean pain score was 7.95 +/- 2.12 (SD) in Group 1, which was significantly higher than in Group 2 (2.76 +/- 0.85), which received the ketorolac-soaked bandage contact lens. The UHPLC results showed that the soaked bandage contact lens acted as a depot for ketorolac, which was released onto the ocular surface over time, providing postoperative pain relief without causing adverse events.

Original language	English
Pages (from-to)	972-976
Number of pages	5
Journal	Journal of Cataract and Refractive Surgery
Volume	45
Issue number	7
DOIs	https://doi.org/10.1016/j.jcrs.2019.01.032
Publication status	Published - Jul 2019

Keywords

NONSTEROIDAL ANTIINFLAMMATORY DRUGS
PRK
EFFICACY
DENSITY
SURFACE

Access to Document

10.1016/j.jcrs.2019.01.032

Cite this

@article{c5d13539b2e74ae6a3a25be2814b0ddc,

title = "Pain management after photorefractive keratectomy",

abstract = "Purpose: To evaluate the effect of a bandage contact lens soaked in ketorolac ophthalmic 0.45% solution (Acuvail) on pain modulation in patients having transepithelial photorefractive keratectomy (PRK).Design: Prospective case series.Setting: Narayana Nethralaya Superspeciality Eye Hospital, Bangalore, India.Methods: Eyes of patients were divided into 2 groups. After transepithelial PRK, a regular soft bandage contact lens was placed in Group 1 and a ketorolac-soaked bandage contact lens was placed in Group 2. The patients were matched for age and sex in the 2 groups. Postoperative pain was compared using the validated Wong-Baker pain scale. Before placement of a ketorolac-soaked bandage contact lens in patients' eyes, the safety of the procedure was checked using cultures from the bandage contact lens and measuring the quantity of the drug adsorbed and the elution profile over time with ultra-high-performance liquid chromatography (UHPLC).Results: Each group comprised 35 eyes of 35 patients. The mean pain score was 7.95 +/- 2.12 (SD) in Group 1, which was significantly higher than in Group 2 (2.76 +/- 0.85), which received the ketorolac-soaked bandage contact lens. The UHPLC results showed that the soaked bandage contact lens acted as a depot for ketorolac, which was released onto the ocular surface over time, providing postoperative pain relief without causing adverse events.Conclusion: A bandage contact lens soaked in ketorolac 0.45% solution can act as a potential drug depot that can reduce pain after transepithelial PRK. (C) 2019 ASCRS and ESCRS",

keywords = "NONSTEROIDAL ANTIINFLAMMATORY DRUGS, PRK, EFFICACY, DENSITY, SURFACE",

author = "Rohit Shetty and Ritika Dalal and Nair, {Archana Padmanabhan} and Pooja Khamar and Sharon D'Souza and Ravish Vaishnav",

year = "2019",

month = jul,

doi = "10.1016/j.jcrs.2019.01.032",

language = "English",

volume = "45",

pages = "972--976",

journal = "Journal of Cataract and Refractive Surgery",

issn = "0886-3350",

publisher = "Elsevier Science",

number = "7",

}

TY - JOUR

T1 - Pain management after photorefractive keratectomy

AU - Shetty, Rohit

AU - Dalal, Ritika

AU - Nair, Archana Padmanabhan

AU - Khamar, Pooja

AU - D'Souza, Sharon

AU - Vaishnav, Ravish

PY - 2019/7

Y1 - 2019/7

N2 - Purpose: To evaluate the effect of a bandage contact lens soaked in ketorolac ophthalmic 0.45% solution (Acuvail) on pain modulation in patients having transepithelial photorefractive keratectomy (PRK).Design: Prospective case series.Setting: Narayana Nethralaya Superspeciality Eye Hospital, Bangalore, India.Methods: Eyes of patients were divided into 2 groups. After transepithelial PRK, a regular soft bandage contact lens was placed in Group 1 and a ketorolac-soaked bandage contact lens was placed in Group 2. The patients were matched for age and sex in the 2 groups. Postoperative pain was compared using the validated Wong-Baker pain scale. Before placement of a ketorolac-soaked bandage contact lens in patients' eyes, the safety of the procedure was checked using cultures from the bandage contact lens and measuring the quantity of the drug adsorbed and the elution profile over time with ultra-high-performance liquid chromatography (UHPLC).Results: Each group comprised 35 eyes of 35 patients. The mean pain score was 7.95 +/- 2.12 (SD) in Group 1, which was significantly higher than in Group 2 (2.76 +/- 0.85), which received the ketorolac-soaked bandage contact lens. The UHPLC results showed that the soaked bandage contact lens acted as a depot for ketorolac, which was released onto the ocular surface over time, providing postoperative pain relief without causing adverse events.Conclusion: A bandage contact lens soaked in ketorolac 0.45% solution can act as a potential drug depot that can reduce pain after transepithelial PRK. (C) 2019 ASCRS and ESCRS

AB - Purpose: To evaluate the effect of a bandage contact lens soaked in ketorolac ophthalmic 0.45% solution (Acuvail) on pain modulation in patients having transepithelial photorefractive keratectomy (PRK).Design: Prospective case series.Setting: Narayana Nethralaya Superspeciality Eye Hospital, Bangalore, India.Methods: Eyes of patients were divided into 2 groups. After transepithelial PRK, a regular soft bandage contact lens was placed in Group 1 and a ketorolac-soaked bandage contact lens was placed in Group 2. The patients were matched for age and sex in the 2 groups. Postoperative pain was compared using the validated Wong-Baker pain scale. Before placement of a ketorolac-soaked bandage contact lens in patients' eyes, the safety of the procedure was checked using cultures from the bandage contact lens and measuring the quantity of the drug adsorbed and the elution profile over time with ultra-high-performance liquid chromatography (UHPLC).Results: Each group comprised 35 eyes of 35 patients. The mean pain score was 7.95 +/- 2.12 (SD) in Group 1, which was significantly higher than in Group 2 (2.76 +/- 0.85), which received the ketorolac-soaked bandage contact lens. The UHPLC results showed that the soaked bandage contact lens acted as a depot for ketorolac, which was released onto the ocular surface over time, providing postoperative pain relief without causing adverse events.Conclusion: A bandage contact lens soaked in ketorolac 0.45% solution can act as a potential drug depot that can reduce pain after transepithelial PRK. (C) 2019 ASCRS and ESCRS

KW - NONSTEROIDAL ANTIINFLAMMATORY DRUGS

KW - PRK

KW - EFFICACY

KW - DENSITY

KW - SURFACE

U2 - 10.1016/j.jcrs.2019.01.032

DO - 10.1016/j.jcrs.2019.01.032

M3 - Article

SN - 0886-3350

VL - 45

SP - 972

EP - 976

JO - Journal of Cataract and Refractive Surgery

JF - Journal of Cataract and Refractive Surgery

IS - 7

ER -