Oxygenation of adipose tissue: A human perspective

Ioannis G. Lempesis, Rens L. J. van Meijel, Konstantinos N. Manolopoulos, Gijs H. Goossens*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

41 Citations (Web of Science)

Abstract

Obesity is a complex disorder of excessive adiposity, and is associated with adverse health effects such as cardiometabolic complications, which are to a large extent attributable to dysfunctional white adipose tissue. Adipose tissue dysfunction is characterized by adipocyte hypertrophy, impaired adipokine secretion, a chronic low-grade inflammatory status, hormonal resistance and altered metabolic responses, together contributing to insulin resistance and related chronic diseases. Adipose tissue hypoxia, defined as a relative oxygen deficit, in obesity has been proposed as a potential contributor to adipose tissue dysfunction, but studies in humans have yielded conflicting results. Here, we will review the role of adipose tissue oxygenation in the pathophysiology of obesity-related complications, with a specific focus on human studies. We will provide an overview of the determinants of adipose tissue oxygenation, as well as the role of adipose tissue oxygenation in glucose homeostasis, lipid metabolism and inflammation. Finally, we will discuss the putative effects of physiological and experimental hypoxia on adipose tissue biology and whole-body metabolism in humans. We conclude that several lines of evidence suggest that alteration of adipose tissue oxygenation may impact metabolic homeostasis, thereby providing a novel strategy to combat chronic metabolic diseases in obese humans.

Original languageEnglish
Article number13298
Number of pages17
JournalActa Physiologica
Volume228
Issue number1
DOIs
Publication statusPublished - Jan 2020

Keywords

  • adipose tissue
  • hypoxia
  • inflammation
  • metabolism
  • obesity
  • oxygen
  • BODY-MASS INDEX
  • IMPROVES INSULIN SENSITIVITY
  • METABOLICALLY HEALTHY OBESITY
  • NORMOBARIC HYPOXIA
  • WEIGHT-LOSS
  • GENE-EXPRESSION
  • BLOOD-FLOW
  • MITOCHONDRIAL BIOGENESIS
  • ADIPOKINE EXPRESSION
  • EXTRACELLULAR-MATRIX

Cite this