Objective: To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.
Design: Retrospective, observational cohort study.
Methods: We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.
Results: Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients.
Conclusion: In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.
|Number of pages||10|
|Journal||Frontiers in Endocrinology|
|Publication status||Published - 14 Dec 2021|
- Acute Kidney Injury/complications
- Hospital Mortality
- Intensive Care Units
- Length of Stay
- Middle Aged
- Patient Discharge
- Respiration, Artificial
- Respiratory Distress Syndrome/complications
- Retrospective Studies
- Treatment Outcome
- EXERCISE-INDUCED BRONCHOSPASM
- INFLAMMATORY MECHANISMS
- BODY-MASS INDEX
- NONASTHMATIC OBESE