Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study

Jamie van Son, Sabrina M Oussaada, Aydin Sekercan, Martijn Beudel, Dave A Dongelmans, Sander van Assen, Ingo A Eland, Hazra S Moeniralam, Tom P J Dormans, Colin A J van Kalkeren, Renee A. Douma, Daisy Rusch, Suat Simsek, Limmie Liu, Ruud S Kootte, Caroline E Wyers, Richard G IJzerman, Joop P van den Bergh, Coen D A Stehouwer, Max NieuwdorpKasper W Ter Horst, Mireille J Serlie*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)


Objective: To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.

Design: Retrospective, observational cohort study.

Methods: We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.

Results: Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients.

Conclusion: In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.

Original languageEnglish
Article number747732
Number of pages10
JournalFrontiers in Endocrinology
Publication statusPublished - 14 Dec 2021


  • Acute Kidney Injury/complications
  • Aged
  • COVID-19/mortality
  • Female
  • Hospital Mortality
  • Hospitalization
  • Humans
  • Intensive Care Units
  • Length of Stay
  • Male
  • Middle Aged
  • Obesity/complications
  • Patient Discharge
  • Respiration, Artificial
  • Respiratory Distress Syndrome/complications
  • Retrospective Studies
  • Treatment Outcome
  • COVID-19
  • overweight
  • obesity
  • complications
  • mortality

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