Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study

Jamie van Son; Sabrina M Oussaada; Aydin Sekercan; Martijn Beudel; Dave A Dongelmans; Sander van Assen; Ingo A Eland; Hazra S Moeniralam; Tom P J Dormans; Colin A J van Kalkeren; Renee A. Douma; Daisy Rusch; Suat Simsek; Limmie Liu; Ruud S Kootte; Caroline E Wyers; Richard G IJzerman; Joop P van den Bergh; Coen D A Stehouwer; Max Nieuwdorp; Kasper W Ter Horst; Mireille J Serlie

doi:10.3389/fendo.2021.747732

Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study

Jamie van Son, Sabrina M Oussaada, Aydin Sekercan, Martijn Beudel, Dave A Dongelmans, Sander van Assen, Ingo A Eland, Hazra S Moeniralam, Tom P J Dormans, Colin A J van Kalkeren, Renee A. Douma, Daisy Rusch, Suat Simsek, Limmie Liu, Ruud S Kootte, Caroline E Wyers, Richard G IJzerman, Joop P van den Bergh, Coen D A Stehouwer, Max NieuwdorpKasper W Ter Horst, Mireille J Serlie^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.

Design: Retrospective, observational cohort study.

Methods: We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.

Results: Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients.

Conclusion: In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.

Original language	English
Article number	747732
Number of pages	10
Journal	Frontiers in Endocrinology
Volume	12
DOIs	https://doi.org/10.3389/fendo.2021.747732
Publication status	Published - 14 Dec 2021

Keywords

Acute Kidney Injury/complications
Aged
COVID-19/mortality
Female
Hospital Mortality
Hospitalization
Humans
Intensive Care Units
Length of Stay
Male
Middle Aged
Obesity/complications
Patient Discharge
Respiration, Artificial
Respiratory Distress Syndrome/complications
Retrospective Studies
Treatment Outcome
EXERCISE-INDUCED BRONCHOSPASM
COVID-19
INFLAMMATORY MECHANISMS
COMORBIDITIES
HEALTH
overweight
obesity
RISK-FACTORS
complications
IDENTIFICATION
DISEASE
mortality
BODY-MASS INDEX
NONASTHMATIC OBESE
SOCIOECONOMIC-STATUS

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10.3389/fendo.2021.747732Licence: CC BY

Cite this

van Son, J., Oussaada, S. M., Sekercan, A., Beudel, M., Dongelmans, D. A., van Assen, S., Eland, I. A., Moeniralam, H. S., Dormans, T. P. J., van Kalkeren, C. A. J., Douma, R. A., Rusch, D., Simsek, S., Liu, L., Kootte, R. S., Wyers, C. E., IJzerman, R. G., van den Bergh, J. P., Stehouwer, C. D. A., ... Serlie, M. J. (2021). Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study. Frontiers in Endocrinology, 12, Article 747732. https://doi.org/10.3389/fendo.2021.747732

@article{e271c2477b4345b2a4127e83c7a5555e,

title = "Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study",

abstract = "Objective: To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.Design: Retrospective, observational cohort study.Methods: We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.Results: Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients.Conclusion: In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.",

keywords = "Acute Kidney Injury/complications, Aged, COVID-19/mortality, Female, Hospital Mortality, Hospitalization, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Obesity/complications, Patient Discharge, Respiration, Artificial, Respiratory Distress Syndrome/complications, Retrospective Studies, Treatment Outcome, EXERCISE-INDUCED BRONCHOSPASM, COVID-19, INFLAMMATORY MECHANISMS, COMORBIDITIES, HEALTH, overweight, obesity, RISK-FACTORS, complications, IDENTIFICATION, DISEASE, mortality, BODY-MASS INDEX, NONASTHMATIC OBESE, SOCIOECONOMIC-STATUS",

author = "{van Son}, Jamie and Oussaada, {Sabrina M} and Aydin Sekercan and Martijn Beudel and Dongelmans, {Dave A} and {van Assen}, Sander and Eland, {Ingo A} and Moeniralam, {Hazra S} and Dormans, {Tom P J} and {van Kalkeren}, {Colin A J} and Douma, {Renee A.} and Daisy Rusch and Suat Simsek and Limmie Liu and Kootte, {Ruud S} and Wyers, {Caroline E} and IJzerman, {Richard G} and {van den Bergh}, {Joop P} and Stehouwer, {Coen D A} and Max Nieuwdorp and {Ter Horst}, {Kasper W} and Serlie, {Mireille J}",

note = "Copyright {\textcopyright} 2021 van Son, Oussaada, {\c S}ekercan, Beudel, Dongelmans, van Assen, Eland, Moeniralam, Dormans, van Kalkeren, Douma, Rusch, Simsek, Liu, Kootte, Wyers, IJzerman, van den Bergh, Stehouwer, Nieuwdorp, ter Horst and Serlie.",

year = "2021",

month = dec,

day = "14",

doi = "10.3389/fendo.2021.747732",

language = "English",

volume = "12",

journal = "Frontiers in Endocrinology",

issn = "1664-2392",

publisher = "Frontiers Media S.A.",

}

van Son, J, Oussaada, SM, Sekercan, A, Beudel, M, Dongelmans, DA, van Assen, S, Eland, IA, Moeniralam, HS, Dormans, TPJ, van Kalkeren, CAJ, Douma, RA, Rusch, D, Simsek, S, Liu, L, Kootte, RS, Wyers, CE, IJzerman, RG, van den Bergh, JP , Stehouwer, CDA, Nieuwdorp, M, Ter Horst, KW & Serlie, MJ 2021, 'Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study', Frontiers in Endocrinology, vol. 12, 747732. https://doi.org/10.3389/fendo.2021.747732

Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study. / van Son, Jamie; Oussaada, Sabrina M; Sekercan, Aydin et al.
In: Frontiers in Endocrinology, Vol. 12, 747732, 14.12.2021.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients

T2 - A Retrospective Cohort Study

AU - van Son, Jamie

AU - Oussaada, Sabrina M

AU - Sekercan, Aydin

AU - Beudel, Martijn

AU - Dongelmans, Dave A

AU - van Assen, Sander

AU - Eland, Ingo A

AU - Moeniralam, Hazra S

AU - Dormans, Tom P J

AU - van Kalkeren, Colin A J

AU - Douma, Renee A.

AU - Rusch, Daisy

AU - Simsek, Suat

AU - Liu, Limmie

AU - Kootte, Ruud S

AU - Wyers, Caroline E

AU - IJzerman, Richard G

AU - van den Bergh, Joop P

AU - Stehouwer, Coen D A

AU - Nieuwdorp, Max

AU - Ter Horst, Kasper W

AU - Serlie, Mireille J

N1 - Copyright © 2021 van Son, Oussaada, Şekercan, Beudel, Dongelmans, van Assen, Eland, Moeniralam, Dormans, van Kalkeren, Douma, Rusch, Simsek, Liu, Kootte, Wyers, IJzerman, van den Bergh, Stehouwer, Nieuwdorp, ter Horst and Serlie.

PY - 2021/12/14

Y1 - 2021/12/14

N2 - Objective: To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.Design: Retrospective, observational cohort study.Methods: We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.Results: Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients.Conclusion: In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.

AB - Objective: To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.Design: Retrospective, observational cohort study.Methods: We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.Results: Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients.Conclusion: In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.

KW - Acute Kidney Injury/complications

KW - Aged

KW - COVID-19/mortality

KW - Female

KW - Hospital Mortality

KW - Hospitalization

KW - Humans

KW - Intensive Care Units

KW - Length of Stay

KW - Male

KW - Middle Aged

KW - Obesity/complications

KW - Patient Discharge

KW - Respiration, Artificial

KW - Respiratory Distress Syndrome/complications

KW - Retrospective Studies

KW - Treatment Outcome

KW - EXERCISE-INDUCED BRONCHOSPASM

KW - COVID-19

KW - INFLAMMATORY MECHANISMS

KW - COMORBIDITIES

KW - HEALTH

KW - overweight

KW - obesity

KW - RISK-FACTORS

KW - complications

KW - IDENTIFICATION

KW - DISEASE

KW - mortality

KW - BODY-MASS INDEX

KW - NONASTHMATIC OBESE

KW - SOCIOECONOMIC-STATUS

U2 - 10.3389/fendo.2021.747732

DO - 10.3389/fendo.2021.747732

M3 - Article

C2 - 34970220

SN - 1664-2392

VL - 12

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

M1 - 747732

ER -