Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium

Renee T. Fortner; Elizabeth M. Poole; Nicolas A. Wentzensen; Britton Trabert; Emily White; Alan A. Arslan; Alpa Patel; V. Wendy Setiawan; Kala Visvanathan; Elisabete Weiderpass; Hans-Olov Adami; Amanda Black; Leslie Bernstein; Louise A. Brinton; Julie Buring; Tess Clendenen; Agnes Fournier; Gary Fraser; Susan M. Gapstur; Mia M. Gaudet; Graham G. Giles; Inger T. Gram; Patricia Hartge; Judith Hoffman-Bolton; Annika Idahl; Rudolf Kaaks; Victoria A. Kirsh; Synnove Knutsen; Woon-Puay Koh; James V. Lacey; I-Min Lee; Eva Lundin; Melissa A. Merritt; Roger L. Milne; N. Charlotte Onland-Moret; Ulrike Peters; Jenny N. Poynter; Sabina Rinaldi; Kim Robien; Thomas Rohan; Maria-Jose Sanchez; Catherine Schairer; Leo J. Schouten; Anne Tjonneland; Mary K. Townsend; Ruth C. Travis; Antonia Trichopoulou; Piet A. van den Brandt; Paolo Vineis; Lynne Wilkens; Alicja Wolk; Hannah P. Yang; Anne Zeleniuch-Jacquotte; Shelley S. Tworoger

doi:10.1002/ijc.32075

Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium

Renee T. Fortner^*
, Elizabeth M. Poole
, Nicolas A. Wentzensen
, Britton Trabert
, Emily White
, Alan A. Arslan
, Alpa Patel
, V. Wendy Setiawan
, Kala Visvanathan
, Elisabete Weiderpass
, Hans-Olov Adami
, Amanda Black
, Leslie Bernstein
, Louise A. Brinton
, Julie Buring
, Tess Clendenen
, Agnes Fournier
, Gary Fraser
, Susan M. Gapstur
, Mia M. Gaudet

Graham G. Giles, Inger T. Gram, Patricia Hartge, Judith Hoffman-Bolton, Annika Idahl, Rudolf Kaaks, Victoria A. Kirsh, Synnove Knutsen, Woon-Puay Koh, James V. Lacey, I-Min Lee, Eva Lundin, Melissa A. Merritt, Roger L. Milne, N. Charlotte Onland-Moret, Ulrike Peters, Jenny N. Poynter, Sabina Rinaldi, Kim Robien, Thomas Rohan, Maria-Jose Sanchez, Catherine Schairer, Leo J. Schouten, Anne Tjonneland, Mary K. Townsend, Ruth C. Travis, Antonia Trichopoulou, Piet A. van den Brandt, Paolo Vineis, Lynne Wilkens, Alicja Wolk, Hannah P. Yang, Anne Zeleniuch-Jacquotte, Shelley S. Tworoger

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to <25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.

Original language	English
Pages (from-to)	58-69
Number of pages	12
Journal	International Journal of Cancer
Volume	145
Issue number	1
DOIs	https://doi.org/10.1002/ijc.32075
Publication status	Published - 1 Jul 2019

Keywords

ASSOCIATION
BREAST-CANCER
CHEMOTHERAPY
ENDOMETRIAL CANCER
OBESITY
POSTMENOPAUSAL WOMEN
PROLACTIN LEVELS
SEX STEROIDS
SMOKING
SURVIVAL
aggressiveness
ovarian cancer
prospective cohort
risk factors
subtypes

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Fortner, R. T., Poole, E. M., Wentzensen, N. A., Trabert, B., White, E., Arslan, A. A., Patel, A., Setiawan, V. W., Visvanathan, K., Weiderpass, E., Adami, H.-O., Black, A., Bernstein, L., Brinton, L. A., Buring, J., Clendenen, T., Fournier, A., Fraser, G., Gapstur, S. M., ... Tworoger, S. S. (2019). Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium. International Journal of Cancer, 145(1), 58-69. https://doi.org/10.1002/ijc.32075

@article{7a3500f73e5242bebec300312b8faf81,

title = "Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium",

abstract = "Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to <25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.",

keywords = "ASSOCIATION, BREAST-CANCER, CHEMOTHERAPY, ENDOMETRIAL CANCER, OBESITY, POSTMENOPAUSAL WOMEN, PROLACTIN LEVELS, SEX STEROIDS, SMOKING, SURVIVAL, aggressiveness, ovarian cancer, prospective cohort, risk factors, subtypes",

author = "Fortner, \{Renee T.\} and Poole, \{Elizabeth M.\} and Wentzensen, \{Nicolas A.\} and Britton Trabert and Emily White and Arslan, \{Alan A.\} and Alpa Patel and Setiawan, \{V. Wendy\} and Kala Visvanathan and Elisabete Weiderpass and Hans-Olov Adami and Amanda Black and Leslie Bernstein and Brinton, \{Louise A.\} and Julie Buring and Tess Clendenen and Agnes Fournier and Gary Fraser and Gapstur, \{Susan M.\} and Gaudet, \{Mia M.\} and Giles, \{Graham G.\} and Gram, \{Inger T.\} and Patricia Hartge and Judith Hoffman-Bolton and Annika Idahl and Rudolf Kaaks and Kirsh, \{Victoria A.\} and Synnove Knutsen and Woon-Puay Koh and Lacey, \{James V.\} and I-Min Lee and Eva Lundin and Merritt, \{Melissa A.\} and Milne, \{Roger L.\} and Onland-Moret, \{N. Charlotte\} and Ulrike Peters and Poynter, \{Jenny N.\} and Sabina Rinaldi and Kim Robien and Thomas Rohan and Maria-Jose Sanchez and Catherine Schairer and Schouten, \{Leo J.\} and Anne Tjonneland and Townsend, \{Mary K.\} and Travis, \{Ruth C.\} and Antonia Trichopoulou and \{van den Brandt\}, \{Piet A.\} and Paolo Vineis and Lynne Wilkens and Alicja Wolk and Yang, \{Hannah P.\} and Anne Zeleniuch-Jacquotte and Tworoger, \{Shelley S.\}",

year = "2019",

month = jul,

day = "1",

doi = "10.1002/ijc.32075",

language = "English",

volume = "145",

pages = "58--69",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley \& Sons Inc.",

number = "1",

}

Fortner, RT, Poole, EM, Wentzensen, NA, Trabert, B, White, E, Arslan, AA, Patel, A, Setiawan, VW, Visvanathan, K, Weiderpass, E, Adami, H-O, Black, A, Bernstein, L, Brinton, LA, Buring, J, Clendenen, T, Fournier, A, Fraser, G, Gapstur, SM, Gaudet, MM, Giles, GG, Gram, IT, Hartge, P, Hoffman-Bolton, J, Idahl, A, Kaaks, R, Kirsh, VA, Knutsen, S, Koh, W-P, Lacey, JV, Lee, I-M, Lundin, E, Merritt, MA, Milne, RL, Onland-Moret, NC, Peters, U, Poynter, JN, Rinaldi, S, Robien, K, Rohan, T, Sanchez, M-J, Schairer, C, Schouten, LJ, Tjonneland, A, Townsend, MK, Travis, RC, Trichopoulou, A, van den Brandt, PA, Vineis, P, Wilkens, L, Wolk, A, Yang, HP, Zeleniuch-Jacquotte, A & Tworoger, SS 2019, 'Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium', International Journal of Cancer, vol. 145, no. 1, pp. 58-69. https://doi.org/10.1002/ijc.32075

TY - JOUR

T1 - Ovarian cancer risk factors by tumor aggressiveness

T2 - An analysis from the Ovarian Cancer Cohort Consortium

AU - Fortner, Renee T.

AU - Poole, Elizabeth M.

AU - Wentzensen, Nicolas A.

AU - Trabert, Britton

AU - White, Emily

AU - Arslan, Alan A.

AU - Patel, Alpa

AU - Setiawan, V. Wendy

AU - Visvanathan, Kala

AU - Weiderpass, Elisabete

AU - Adami, Hans-Olov

AU - Black, Amanda

AU - Bernstein, Leslie

AU - Brinton, Louise A.

AU - Buring, Julie

AU - Clendenen, Tess

AU - Fournier, Agnes

AU - Fraser, Gary

AU - Gapstur, Susan M.

AU - Gaudet, Mia M.

AU - Giles, Graham G.

AU - Gram, Inger T.

AU - Hartge, Patricia

AU - Hoffman-Bolton, Judith

AU - Idahl, Annika

AU - Kaaks, Rudolf

AU - Kirsh, Victoria A.

AU - Knutsen, Synnove

AU - Koh, Woon-Puay

AU - Lacey, James V.

AU - Lee, I-Min

AU - Lundin, Eva

AU - Merritt, Melissa A.

AU - Milne, Roger L.

AU - Onland-Moret, N. Charlotte

AU - Peters, Ulrike

AU - Poynter, Jenny N.

AU - Rinaldi, Sabina

AU - Robien, Kim

AU - Rohan, Thomas

AU - Sanchez, Maria-Jose

AU - Schairer, Catherine

AU - Schouten, Leo J.

AU - Tjonneland, Anne

AU - Townsend, Mary K.

AU - Travis, Ruth C.

AU - Trichopoulou, Antonia

AU - van den Brandt, Piet A.

AU - Vineis, Paolo

AU - Wilkens, Lynne

AU - Wolk, Alicja

AU - Yang, Hannah P.

AU - Zeleniuch-Jacquotte, Anne

AU - Tworoger, Shelley S.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to <25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.

AB - Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to <25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.

KW - ASSOCIATION

KW - BREAST-CANCER

KW - CHEMOTHERAPY

KW - ENDOMETRIAL CANCER

KW - OBESITY

KW - POSTMENOPAUSAL WOMEN

KW - PROLACTIN LEVELS

KW - SEX STEROIDS

KW - SMOKING

KW - SURVIVAL

KW - aggressiveness

KW - ovarian cancer

KW - prospective cohort

KW - risk factors

KW - subtypes

U2 - 10.1002/ijc.32075

DO - 10.1002/ijc.32075

M3 - Article

C2 - 30561796

SN - 0020-7136

VL - 145

SP - 58

EP - 69

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 1

ER -

Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium

Abstract

Keywords

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