Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies

V. Beral; C. Hermon; R. Peto; G. Reeves; L. Brinton; P. Marchbanks; E. Negri; R. Ness; P. H. M. Peeters; M. Vessey; E. E. Calle; S. M. Gapstur; A. V. Patel; L. Dal Maso; R. Talamini; A. Chetrit; G. Hirsh-Yechezkel; F. Lubin; S. Sadetzki; N. Allen; D. Bull; K. Callaghan; B. Crossley; K. Gaitskell; A. Goodill; J. Green; T. Key; K. Moser; R. Collins; R. Doll; C. A. Gonzalez; N. Lee; H. W. Ory; H. B. Peterson; P. A. Wingo; N. Martin; T. Pardthaisong; S. Silpisornkosol; C. Theetranont; B. Boosiri; S. Chutivongse; P. Jimakorn; P. Virutamasen; C. Wongsrichanalai; A. Tjonneland; L. Titus-Ernstoff; T. Byers; T. Rohan; B. J. Mosgaard; D. Yeates; J. L. Freudenheim; J. Chang-Claude; R. Kaaks; K. E. Anderson; A. Folsom; K. Robien; M. A. Rossing; D. B. Thomas; N. S. Weiss; E. Riboli; F. Clavel-Chapelon; D. Cramer; S. E. Hankinson; S. S. Tworoger; S. Franceschi; C. La Vecchia; C. Magnusson; T. Riman; E. Weiderpass; A. Wolk; L. J. Schouten; P. A. van den Brandt; N. Chantarakul; S. Koetsawang; D. Rachawat; D. Palli; A. Black; A. Berrington de Gonzalez; D. M. Freedman; P. Hartge; A. W. Hsing; J. V., Jr. Lacey; R. N. Hoover; C. Schairer; S. Graff-Iversen; R. Selmer; C. J. Bain; A. C. Green; D. M. Purdie; V. Siskind; P. M. Webb; S. E. McCann; P. Hannaford; C. Kay; C. W. Binns; A. H. Lee; M. Zhang; R. B. Ness; P. Nasca; P. F. Coogan; J. R. Palmer; L. Rosenberg; J. Kelsey; R. Paffenbarger; A. Whittemore; K. Katsouyanni; A. Trichopoulou; D. Trichopoulos; A. Tzonou; A. Dabancens; L. Martinez; R. Molina; O. Salas; M. T. Goodman; G. Lurie; M. E. Carney; L. R. Wilkens; L. Hartman; J. Manjer; H. Olsson; J. A. Grisso; M. Morgan; J. E. Wheeler; J. Casagrande; M. C. Pike; R. K. Ross; A. H. Wu; A. B. Miller; M. Kumle; E. Lund; L. McGowan; X. O. Shu; W. Zheng; T. M. M. Farley; S. Holck; O. Meirik; H. A. Risch

doi:10.1371/journal.pmed.1001200

Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies

V. Beral^*, C. Hermon, R. Peto, G. Reeves, L. Brinton, P. Marchbanks, E. Negri, R. Ness, P. H. M. Peeters, M. Vessey, E. E. Calle, S. M. Gapstur, A. V. Patel, L. Dal Maso, R. Talamini, A. Chetrit, G. Hirsh-Yechezkel, F. Lubin, S. Sadetzki, N. AllenD. Bull, K. Callaghan, B. Crossley, K. Gaitskell, A. Goodill, J. Green, T. Key, K. Moser, R. Collins, R. Doll, C. A. Gonzalez, N. Lee, H. W. Ory, H. B. Peterson, P. A. Wingo, N. Martin, T. Pardthaisong, S. Silpisornkosol, C. Theetranont, B. Boosiri, S. Chutivongse, P. Jimakorn, P. Virutamasen, C. Wongsrichanalai, A. Tjonneland, L. Titus-Ernstoff, T. Byers, T. Rohan, B. J. Mosgaard, D. Yeates, J. L. Freudenheim, J. Chang-Claude, R. Kaaks, K. E. Anderson, A. Folsom, K. Robien, M. A. Rossing, D. B. Thomas, N. S. Weiss, E. Riboli, F. Clavel-Chapelon, D. Cramer, S. E. Hankinson, S. S. Tworoger, S. Franceschi, C. La Vecchia, C. Magnusson, T. Riman, E. Weiderpass, A. Wolk, L. J. Schouten, P. A. van den Brandt, N. Chantarakul, S. Koetsawang, D. Rachawat, D. Palli, A. Black, A. Berrington de Gonzalez, D. M. Freedman, P. Hartge, A. W. Hsing, J. V., Jr. Lacey, R. N. Hoover, C. Schairer, S. Graff-Iversen, R. Selmer, C. J. Bain, A. C. Green, D. M. Purdie, V. Siskind, P. M. Webb, S. E. McCann, P. Hannaford, C. Kay, C. W. Binns, A. H. Lee, M. Zhang, R. B. Ness, P. Nasca, P. F. Coogan, J. R. Palmer, L. Rosenberg, J. Kelsey, R. Paffenbarger, A. Whittemore, K. Katsouyanni, A. Trichopoulou, D. Trichopoulos, A. Tzonou, A. Dabancens, L. Martinez, R. Molina, O. Salas, M. T. Goodman, G. Lurie, M. E. Carney, L. R. Wilkens, L. Hartman, J. Manjer, H. Olsson, J. A. Grisso, M. Morgan, J. E. Wheeler, J. Casagrande, M. C. Pike, R. K. Ross, A. H. Wu, A. B. Miller, M. Kumle, E. Lund, L. McGowan, X. O. Shu, W. Zheng, T. M. M. Farley, S. Holck, O. Meirik, H. A. Risch

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital controls. For other study designs, the relative risk of ovarian cancer per 5 cm increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09; p

Original language	English
Pages (from-to)	e1001200
Journal	PLoS Medicine
Volume	9
Issue number	4
DOIs	https://doi.org/10.1371/journal.pmed.1001200
Publication status	Published - Apr 2012

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10.1371/journal.pmed.1001200Licence: CC BY

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Beral, V., Hermon, C., Peto, R., Reeves, G., Brinton, L., Marchbanks, P., Negri, E., Ness, R., Peeters, P. H. M., Vessey, M., Calle, E. E., Gapstur, S. M., Patel, A. V., Dal Maso, L., Talamini, R., Chetrit, A., Hirsh-Yechezkel, G., Lubin, F., Sadetzki, S., ... Risch, H. A. (2012). Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies. PLoS Medicine, 9(4), e1001200. https://doi.org/10.1371/journal.pmed.1001200

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title = "Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies",

abstract = "Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital controls. For other study designs, the relative risk of ovarian cancer per 5 cm increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09; p",

author = "V. Beral and C. Hermon and R. Peto and G. Reeves and L. Brinton and P. Marchbanks and E. Negri and R. Ness and Peeters, {P. H. M.} and M. Vessey and Calle, {E. E.} and Gapstur, {S. M.} and Patel, {A. V.} and {Dal Maso}, L. and R. Talamini and A. Chetrit and G. Hirsh-Yechezkel and F. Lubin and S. Sadetzki and N. Allen and D. Bull and K. Callaghan and B. Crossley and K. Gaitskell and A. Goodill and J. Green and T. Key and K. Moser and R. Collins and R. Doll and Gonzalez, {C. A.} and N. Lee and Ory, {H. W.} and Peterson, {H. B.} and Wingo, {P. A.} and N. Martin and T. Pardthaisong and S. Silpisornkosol and C. Theetranont and B. Boosiri and S. Chutivongse and P. Jimakorn and P. Virutamasen and C. Wongsrichanalai and A. Tjonneland and L. Titus-Ernstoff and T. Byers and T. Rohan and Mosgaard, {B. J.} and D. Yeates and Freudenheim, {J. L.} and J. Chang-Claude and R. Kaaks and Anderson, {K. E.} and A. Folsom and K. Robien and Rossing, {M. A.} and Thomas, {D. B.} and Weiss, {N. S.} and E. Riboli and F. Clavel-Chapelon and D. Cramer and Hankinson, {S. E.} and Tworoger, {S. S.} and S. Franceschi and {La Vecchia}, C. and C. Magnusson and T. Riman and E. Weiderpass and A. Wolk and Schouten, {L. J.} and {van den Brandt}, {P. A.} and N. Chantarakul and S. Koetsawang and D. Rachawat and D. Palli and A. Black and {de Gonzalez}, {A. Berrington} and Freedman, {D. M.} and P. Hartge and Hsing, {A. W.} and Lacey, {J. V., Jr.} and Hoover, {R. N.} and C. Schairer and S. Graff-Iversen and R. Selmer and Bain, {C. J.} and Green, {A. C.} and Purdie, {D. M.} and V. Siskind and Webb, {P. M.} and McCann, {S. E.} and P. Hannaford and C. Kay and Binns, {C. W.} and Lee, {A. H.} and M. Zhang and Ness, {R. B.} and P. Nasca and Coogan, {P. F.} and Palmer, {J. R.} and L. Rosenberg and J. Kelsey and R. Paffenbarger and A. Whittemore and K. Katsouyanni and A. Trichopoulou and D. Trichopoulos and A. Tzonou and A. Dabancens and L. Martinez and R. Molina and O. Salas and Goodman, {M. T.} and G. Lurie and Carney, {M. E.} and Wilkens, {L. R.} and L. Hartman and J. Manjer and H. Olsson and Grisso, {J. A.} and M. Morgan and Wheeler, {J. E.} and J. Casagrande and Pike, {M. C.} and Ross, {R. K.} and Wu, {A. H.} and Miller, {A. B.} and M. Kumle and E. Lund and L. McGowan and Shu, {X. O.} and W. Zheng and Farley, {T. M. M.} and S. Holck and O. Meirik and Risch, {H. A.}",

year = "2012",

month = apr,

doi = "10.1371/journal.pmed.1001200",

language = "English",

volume = "9",

pages = "e1001200",

journal = "PLoS Medicine",

issn = "1549-1277",

publisher = "Public Library of Science",

number = "4",

}

Beral, V, Hermon, C, Peto, R, Reeves, G, Brinton, L, Marchbanks, P, Negri, E, Ness, R, Peeters, PHM, Vessey, M, Calle, EE, Gapstur, SM, Patel, AV, Dal Maso, L, Talamini, R, Chetrit, A, Hirsh-Yechezkel, G, Lubin, F, Sadetzki, S, Allen, N, Bull, D, Callaghan, K, Crossley, B, Gaitskell, K, Goodill, A, Green, J, Key, T, Moser, K, Collins, R, Doll, R, Gonzalez, CA, Lee, N, Ory, HW, Peterson, HB, Wingo, PA, Martin, N, Pardthaisong, T, Silpisornkosol, S, Theetranont, C, Boosiri, B, Chutivongse, S, Jimakorn, P, Virutamasen, P, Wongsrichanalai, C, Tjonneland, A, Titus-Ernstoff, L, Byers, T, Rohan, T, Mosgaard, BJ, Yeates, D, Freudenheim, JL, Chang-Claude, J, Kaaks, R, Anderson, KE, Folsom, A, Robien, K, Rossing, MA, Thomas, DB, Weiss, NS, Riboli, E, Clavel-Chapelon, F, Cramer, D, Hankinson, SE, Tworoger, SS, Franceschi, S, La Vecchia, C, Magnusson, C, Riman, T, Weiderpass, E, Wolk, A, Schouten, LJ , van den Brandt, PA, Chantarakul, N, Koetsawang, S, Rachawat, D, Palli, D, Black, A, de Gonzalez, AB, Freedman, DM, Hartge, P, Hsing, AW, Lacey, JVJ, Hoover, RN, Schairer, C, Graff-Iversen, S, Selmer, R, Bain, CJ, Green, AC, Purdie, DM, Siskind, V, Webb, PM, McCann, SE, Hannaford, P, Kay, C, Binns, CW, Lee, AH, Zhang, M, Ness, RB, Nasca, P, Coogan, PF, Palmer, JR, Rosenberg, L, Kelsey, J, Paffenbarger, R, Whittemore, A, Katsouyanni, K, Trichopoulou, A, Trichopoulos, D, Tzonou, A, Dabancens, A, Martinez, L, Molina, R, Salas, O, Goodman, MT, Lurie, G, Carney, ME, Wilkens, LR, Hartman, L, Manjer, J, Olsson, H, Grisso, JA, Morgan, M, Wheeler, JE, Casagrande, J, Pike, MC, Ross, RK, Wu, AH, Miller, AB, Kumle, M, Lund, E, McGowan, L, Shu, XO, Zheng, W, Farley, TMM, Holck, S, Meirik, O & Risch, HA 2012, 'Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies', PLoS Medicine, vol. 9, no. 4, pp. e1001200. https://doi.org/10.1371/journal.pmed.1001200

TY - JOUR

T1 - Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies

AU - Beral, V.

AU - Hermon, C.

AU - Peto, R.

AU - Reeves, G.

AU - Brinton, L.

AU - Marchbanks, P.

AU - Negri, E.

AU - Ness, R.

AU - Peeters, P. H. M.

AU - Vessey, M.

AU - Calle, E. E.

AU - Gapstur, S. M.

AU - Patel, A. V.

AU - Dal Maso, L.

AU - Talamini, R.

AU - Chetrit, A.

AU - Hirsh-Yechezkel, G.

AU - Lubin, F.

AU - Sadetzki, S.

AU - Allen, N.

AU - Bull, D.

AU - Callaghan, K.

AU - Crossley, B.

AU - Gaitskell, K.

AU - Goodill, A.

AU - Green, J.

AU - Key, T.

AU - Moser, K.

AU - Collins, R.

AU - Doll, R.

AU - Gonzalez, C. A.

AU - Lee, N.

AU - Ory, H. W.

AU - Peterson, H. B.

AU - Wingo, P. A.

AU - Martin, N.

AU - Pardthaisong, T.

AU - Silpisornkosol, S.

AU - Theetranont, C.

AU - Boosiri, B.

AU - Chutivongse, S.

AU - Jimakorn, P.

AU - Virutamasen, P.

AU - Wongsrichanalai, C.

AU - Tjonneland, A.

AU - Titus-Ernstoff, L.

AU - Byers, T.

AU - Rohan, T.

AU - Mosgaard, B. J.

AU - Yeates, D.

AU - Freudenheim, J. L.

AU - Chang-Claude, J.

AU - Kaaks, R.

AU - Anderson, K. E.

AU - Folsom, A.

AU - Robien, K.

AU - Rossing, M. A.

AU - Thomas, D. B.

AU - Weiss, N. S.

AU - Riboli, E.

AU - Clavel-Chapelon, F.

AU - Cramer, D.

AU - Hankinson, S. E.

AU - Tworoger, S. S.

AU - Franceschi, S.

AU - La Vecchia, C.

AU - Magnusson, C.

AU - Riman, T.

AU - Weiderpass, E.

AU - Wolk, A.

AU - Schouten, L. J.

AU - van den Brandt, P. A.

AU - Chantarakul, N.

AU - Koetsawang, S.

AU - Rachawat, D.

AU - Palli, D.

AU - Black, A.

AU - de Gonzalez, A. Berrington

AU - Freedman, D. M.

AU - Hartge, P.

AU - Hsing, A. W.

AU - Lacey, J. V., Jr.

AU - Hoover, R. N.

AU - Schairer, C.

AU - Graff-Iversen, S.

AU - Selmer, R.

AU - Bain, C. J.

AU - Green, A. C.

AU - Purdie, D. M.

AU - Siskind, V.

AU - Webb, P. M.

AU - McCann, S. E.

AU - Hannaford, P.

AU - Kay, C.

AU - Binns, C. W.

AU - Lee, A. H.

AU - Zhang, M.

AU - Ness, R. B.

AU - Nasca, P.

AU - Coogan, P. F.

AU - Palmer, J. R.

AU - Rosenberg, L.

AU - Kelsey, J.

AU - Paffenbarger, R.

AU - Whittemore, A.

AU - Katsouyanni, K.

AU - Trichopoulou, A.

AU - Trichopoulos, D.

AU - Tzonou, A.

AU - Dabancens, A.

AU - Martinez, L.

AU - Molina, R.

AU - Salas, O.

AU - Goodman, M. T.

AU - Lurie, G.

AU - Carney, M. E.

AU - Wilkens, L. R.

AU - Hartman, L.

AU - Manjer, J.

AU - Olsson, H.

AU - Grisso, J. A.

AU - Morgan, M.

AU - Wheeler, J. E.

AU - Casagrande, J.

AU - Pike, M. C.

AU - Ross, R. K.

AU - Wu, A. H.

AU - Miller, A. B.

AU - Kumle, M.

AU - Lund, E.

AU - McGowan, L.

AU - Shu, X. O.

AU - Zheng, W.

AU - Farley, T. M. M.

AU - Holck, S.

AU - Meirik, O.

AU - Risch, H. A.

PY - 2012/4

Y1 - 2012/4

N2 - Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital controls. For other study designs, the relative risk of ovarian cancer per 5 cm increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09; p

AB - Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital controls. For other study designs, the relative risk of ovarian cancer per 5 cm increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09; p

U2 - 10.1371/journal.pmed.1001200

DO - 10.1371/journal.pmed.1001200

M3 - Article

C2 - 22606070

SN - 1549-1277

VL - 9

SP - e1001200

JO - PLoS Medicine

JF - PLoS Medicine

IS - 4

ER -