Outcomes of Hematopoietic Cell Transplantation for Diffuse Large B Cell Lymphoma Transformed from Follicular Lymphoma

Baldeep Wirk; Timothy S. Fenske; Mehdi Hamadani; Mei-Jie Zhang; Zhen-Huan Hu; Goerguen Akpek; Mahmoud D. Aljurf; Philippe Armand; Ernesto Ayala; Veronika Bachanova; Brian Bolwell; Mitchell S. Cairo; Amanda Cashen; Yi-Bin Chen; Luciano J. Costa; Shatha Farhan; Cesar O. Freytes; James L. Gajewski; John Gibson; Gregory A. Hale; Leona A. Holmberg; Jack W. Hsu; David J. Inwards; Rummurti T. Kamble; Dipnarine Maharaj; Richard T. Maziarz; Reinhold Munker; Rajneesh Nath; Nishitha M. Reddy; Craig B. Reeder; David A. Rizzieri; Craig S. Sauter; Bipin N. Savani; Harry C. Schouten; Anna Sureda; Julie M. Vose; Edmund K. Waller; Peter H. Wiernik; Robert Peter Gale; Linda J. Burns; Wael Saber

doi:10.1016/j.bbmt.2014.03.014

Outcomes of Hematopoietic Cell Transplantation for Diffuse Large B Cell Lymphoma Transformed from Follicular Lymphoma

Baldeep Wirk^*, Timothy S. Fenske, Mehdi Hamadani, Mei-Jie Zhang, Zhen-Huan Hu, Goerguen Akpek, Mahmoud D. Aljurf, Philippe Armand, Ernesto Ayala, Veronika Bachanova, Brian Bolwell, Mitchell S. Cairo, Amanda Cashen, Yi-Bin Chen, Luciano J. Costa, Shatha Farhan, Cesar O. Freytes, James L. Gajewski, John Gibson, Gregory A. HaleLeona A. Holmberg, Jack W. Hsu, David J. Inwards, Rummurti T. Kamble, Dipnarine Maharaj, Richard T. Maziarz, Reinhold Munker, Rajneesh Nath, Nishitha M. Reddy, Craig B. Reeder, David A. Rizzieri, Craig S. Sauter, Bipin N. Savani, Harry C. Schouten, Anna Sureda, Julie M. Vose, Edmund K. Waller, Peter H. Wiernik, Robert Peter Gale, Linda J. Burns, Wael Saber

^*Corresponding author for this work

GROW - Innovative Cancer Diagnostics & Therapy

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

There are limited data on the outcomes of autologous or allogeneic hematopoietic cell transplantation (HCT) in diffuse large B cell lymphoma transformed from follicular lymphoma. We analyzed transplantation outcomes in 141 subjects with biopsy-proven diffuse large B-cell lymphoma transformed from follicular lymphoma reported to the Center for International Blood and Marrow Transplant Research between 1990 and 2009. Two groups were identified: autologous HCT (auto-Ha; n = 108) and allogeneic HCT (allo-HCT; n = 33). Fewer auto-Has were done for transformed follicular lymphoma in 2003 to 2009, with a shift favoring allo-HCT. Auto-HCT was associated with a 1-year nonrelapse mortality (NRM) of 8% (95% confidence interval [CI], 4% to 14%), 5-year progression-free survival of 35% (95% CI, 26% to 45%), and 5-year overall survival of 50% (95% CI, 40% to 59%). In contrast, allo-HCT was associated with a 1-year NRM of 41% (95% CI, 23% to 58%), 5-year progression-free survival of 18% (95% CI, 6% to 35%), and 5-year overall survival of 22% (95% CI, 8% to 41%). Auto-HCT for transformed follicular lymphoma achieves sustained remission in a high proportion of subjects. The high NRM of allo-HCT offset any benefit that might be associated with this transplantation modality.

Original language	English
Pages (from-to)	951-959
Number of pages	9
Journal	Biology of Blood and Marrow Transplantation
Volume	20
Issue number	7
DOIs	https://doi.org/10.1016/j.bbmt.2014.03.014
Publication status	Published - Jul 2014

Keywords

Transformed follicular
lymphoma
Transplant

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Wirk, B., Fenske, T. S., Hamadani, M., Zhang, M.-J., Hu, Z.-H., Akpek, G., Aljurf, M. D., Armand, P., Ayala, E., Bachanova, V., Bolwell, B., Cairo, M. S., Cashen, A., Chen, Y.-B., Costa, L. J., Farhan, S., Freytes, C. O., Gajewski, J. L., Gibson, J., ... Saber, W. (2014). Outcomes of Hematopoietic Cell Transplantation for Diffuse Large B Cell Lymphoma Transformed from Follicular Lymphoma. Biology of Blood and Marrow Transplantation, 20(7), 951-959. https://doi.org/10.1016/j.bbmt.2014.03.014

@article{c6edfdbfebb249c99990196e5fc749db,

title = "Outcomes of Hematopoietic Cell Transplantation for Diffuse Large B Cell Lymphoma Transformed from Follicular Lymphoma",

abstract = "There are limited data on the outcomes of autologous or allogeneic hematopoietic cell transplantation (HCT) in diffuse large B cell lymphoma transformed from follicular lymphoma. We analyzed transplantation outcomes in 141 subjects with biopsy-proven diffuse large B-cell lymphoma transformed from follicular lymphoma reported to the Center for International Blood and Marrow Transplant Research between 1990 and 2009. Two groups were identified: autologous HCT (auto-Ha; n = 108) and allogeneic HCT (allo-HCT; n = 33). Fewer auto-Has were done for transformed follicular lymphoma in 2003 to 2009, with a shift favoring allo-HCT. Auto-HCT was associated with a 1-year nonrelapse mortality (NRM) of 8\% (95\% confidence interval [CI], 4\% to 14\%), 5-year progression-free survival of 35\% (95\% CI, 26\% to 45\%), and 5-year overall survival of 50\% (95\% CI, 40\% to 59\%). In contrast, allo-HCT was associated with a 1-year NRM of 41\% (95\% CI, 23\% to 58\%), 5-year progression-free survival of 18\% (95\% CI, 6\% to 35\%), and 5-year overall survival of 22\% (95\% CI, 8\% to 41\%). Auto-HCT for transformed follicular lymphoma achieves sustained remission in a high proportion of subjects. The high NRM of allo-HCT offset any benefit that might be associated with this transplantation modality. ",

keywords = "Transformed follicular, lymphoma, Transplant",

author = "Baldeep Wirk and Fenske, \{Timothy S.\} and Mehdi Hamadani and Mei-Jie Zhang and Zhen-Huan Hu and Goerguen Akpek and Aljurf, \{Mahmoud D.\} and Philippe Armand and Ernesto Ayala and Veronika Bachanova and Brian Bolwell and Cairo, \{Mitchell S.\} and Amanda Cashen and Yi-Bin Chen and Costa, \{Luciano J.\} and Shatha Farhan and Freytes, \{Cesar O.\} and Gajewski, \{James L.\} and John Gibson and Hale, \{Gregory A.\} and Holmberg, \{Leona A.\} and Hsu, \{Jack W.\} and Inwards, \{David J.\} and Kamble, \{Rummurti T.\} and Dipnarine Maharaj and Maziarz, \{Richard T.\} and Reinhold Munker and Rajneesh Nath and Reddy, \{Nishitha M.\} and Reeder, \{Craig B.\} and Rizzieri, \{David A.\} and Sauter, \{Craig S.\} and Savani, \{Bipin N.\} and Schouten, \{Harry C.\} and Anna Sureda and Vose, \{Julie M.\} and Waller, \{Edmund K.\} and Wiernik, \{Peter H.\} and Gale, \{Robert Peter\} and Burns, \{Linda J.\} and Wael Saber",

year = "2014",

month = jul,

doi = "10.1016/j.bbmt.2014.03.014",

language = "English",

volume = "20",

pages = "951--959",

journal = "Biology of Blood and Marrow Transplantation",

issn = "1083-8791",

publisher = "Elsevier Inc.",

number = "7",

}

Wirk, B, Fenske, TS, Hamadani, M, Zhang, M-J, Hu, Z-H, Akpek, G, Aljurf, MD, Armand, P, Ayala, E, Bachanova, V, Bolwell, B, Cairo, MS, Cashen, A, Chen, Y-B, Costa, LJ, Farhan, S, Freytes, CO, Gajewski, JL, Gibson, J, Hale, GA, Holmberg, LA, Hsu, JW, Inwards, DJ, Kamble, RT, Maharaj, D, Maziarz, RT, Munker, R, Nath, R, Reddy, NM, Reeder, CB, Rizzieri, DA, Sauter, CS, Savani, BN, Schouten, HC, Sureda, A, Vose, JM, Waller, EK, Wiernik, PH, Gale, RP, Burns, LJ & Saber, W 2014, 'Outcomes of Hematopoietic Cell Transplantation for Diffuse Large B Cell Lymphoma Transformed from Follicular Lymphoma', Biology of Blood and Marrow Transplantation, vol. 20, no. 7, pp. 951-959. https://doi.org/10.1016/j.bbmt.2014.03.014

TY - JOUR

T1 - Outcomes of Hematopoietic Cell Transplantation for Diffuse Large B Cell Lymphoma Transformed from Follicular Lymphoma

AU - Wirk, Baldeep

AU - Fenske, Timothy S.

AU - Hamadani, Mehdi

AU - Zhang, Mei-Jie

AU - Hu, Zhen-Huan

AU - Akpek, Goerguen

AU - Aljurf, Mahmoud D.

AU - Armand, Philippe

AU - Ayala, Ernesto

AU - Bachanova, Veronika

AU - Bolwell, Brian

AU - Cairo, Mitchell S.

AU - Cashen, Amanda

AU - Chen, Yi-Bin

AU - Costa, Luciano J.

AU - Farhan, Shatha

AU - Freytes, Cesar O.

AU - Gajewski, James L.

AU - Gibson, John

AU - Hale, Gregory A.

AU - Holmberg, Leona A.

AU - Hsu, Jack W.

AU - Inwards, David J.

AU - Kamble, Rummurti T.

AU - Maharaj, Dipnarine

AU - Maziarz, Richard T.

AU - Munker, Reinhold

AU - Nath, Rajneesh

AU - Reddy, Nishitha M.

AU - Reeder, Craig B.

AU - Rizzieri, David A.

AU - Sauter, Craig S.

AU - Savani, Bipin N.

AU - Schouten, Harry C.

AU - Sureda, Anna

AU - Vose, Julie M.

AU - Waller, Edmund K.

AU - Wiernik, Peter H.

AU - Gale, Robert Peter

AU - Burns, Linda J.

AU - Saber, Wael

PY - 2014/7

Y1 - 2014/7

N2 - There are limited data on the outcomes of autologous or allogeneic hematopoietic cell transplantation (HCT) in diffuse large B cell lymphoma transformed from follicular lymphoma. We analyzed transplantation outcomes in 141 subjects with biopsy-proven diffuse large B-cell lymphoma transformed from follicular lymphoma reported to the Center for International Blood and Marrow Transplant Research between 1990 and 2009. Two groups were identified: autologous HCT (auto-Ha; n = 108) and allogeneic HCT (allo-HCT; n = 33). Fewer auto-Has were done for transformed follicular lymphoma in 2003 to 2009, with a shift favoring allo-HCT. Auto-HCT was associated with a 1-year nonrelapse mortality (NRM) of 8% (95% confidence interval [CI], 4% to 14%), 5-year progression-free survival of 35% (95% CI, 26% to 45%), and 5-year overall survival of 50% (95% CI, 40% to 59%). In contrast, allo-HCT was associated with a 1-year NRM of 41% (95% CI, 23% to 58%), 5-year progression-free survival of 18% (95% CI, 6% to 35%), and 5-year overall survival of 22% (95% CI, 8% to 41%). Auto-HCT for transformed follicular lymphoma achieves sustained remission in a high proportion of subjects. The high NRM of allo-HCT offset any benefit that might be associated with this transplantation modality.

AB - There are limited data on the outcomes of autologous or allogeneic hematopoietic cell transplantation (HCT) in diffuse large B cell lymphoma transformed from follicular lymphoma. We analyzed transplantation outcomes in 141 subjects with biopsy-proven diffuse large B-cell lymphoma transformed from follicular lymphoma reported to the Center for International Blood and Marrow Transplant Research between 1990 and 2009. Two groups were identified: autologous HCT (auto-Ha; n = 108) and allogeneic HCT (allo-HCT; n = 33). Fewer auto-Has were done for transformed follicular lymphoma in 2003 to 2009, with a shift favoring allo-HCT. Auto-HCT was associated with a 1-year nonrelapse mortality (NRM) of 8% (95% confidence interval [CI], 4% to 14%), 5-year progression-free survival of 35% (95% CI, 26% to 45%), and 5-year overall survival of 50% (95% CI, 40% to 59%). In contrast, allo-HCT was associated with a 1-year NRM of 41% (95% CI, 23% to 58%), 5-year progression-free survival of 18% (95% CI, 6% to 35%), and 5-year overall survival of 22% (95% CI, 8% to 41%). Auto-HCT for transformed follicular lymphoma achieves sustained remission in a high proportion of subjects. The high NRM of allo-HCT offset any benefit that might be associated with this transplantation modality.

KW - Transformed follicular

KW - lymphoma

KW - Transplant

U2 - 10.1016/j.bbmt.2014.03.014

DO - 10.1016/j.bbmt.2014.03.014

M3 - Article

C2 - 24641828

SN - 1083-8791

VL - 20

SP - 951

EP - 959

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

IS - 7

ER -

Outcomes of Hematopoietic Cell Transplantation for Diffuse Large B Cell Lymphoma Transformed from Follicular Lymphoma

Abstract

Keywords

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