Outcome in Caucasian patients with hepatitis B e antigen negative chronic infection: A long-term observational cohort study

Ozgur M. Koc*, Geert Robaeys, Halit Topal, Rob Bielen, Dana Busschots, Johan Fevery, Ger H. Koek, Frederik Nevens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

Sensitive polymerase chain reaction assays to measure hepatitis B virus (HBV) DNA became only available the last decade. Hence, the long-term outcome of Caucasian patients in Western Europe with hepatitis B e antigen (HBeAg)-negative chronic infection, especially with a baseline HBV DNA level > 2000 IU/mL, is still unclear. Out of a cohort of 1936 chronic HBV patients, 413 Caucasian individuals were identified with HBeAg-negative chronic infection, defined as persistently normal alanine aminotransferase (ALT) levels and HBV DNA levels 2 x upper limit of normal due to non-HBV-related causes. The cumulative probability of spontaneously developing CAH after 10 years was almost exclusively seen in patients with baseline HBV DNA level > 2000 IU/mL (11.7% vs 1.2%; P <.001). Advanced liver disease developed significantly more in patients with baseline HBV DNA level > 2000 IU/mL (5.2% vs 1.5%; P = .018) and occurred especially in patients with obesity (16.7% vs 4.2%; P = .049). The incidence of hepatocellular carcinoma was 0.0%. Caucasian patients with HBeAg-negative chronic infection and baseline HBV DNA level 2000 IU/mL are at risk to develop advanced liver disease.

Original languageEnglish
Pages (from-to)3373-3380
Number of pages8
JournalJournal of Medical Virology
Volume92
Issue number12
Early online date12 May 2020
DOIs
Publication statusPublished - Dec 2020

Keywords

  • alanine aminotransferase
  • Caucasian race
  • chronic hepatitis B
  • HBeAg-negative chronic infection
  • HBV DNA
  • inactive HBV carrier
  • PERSISTENTLY NORMAL ALT
  • HBV DNA LEVELS
  • NATURAL-HISTORY
  • FOLLOW-UP
  • VIRUS-INFECTION
  • CARRIERS
  • REACTIVATION
  • MANAGEMENT
  • RISK

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