Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

H. Jansson; P.B. Olthof; A. Bergquist; M.A.P. Ligthart; S. Nadalin; R.I. Troisi; B.G. Koerkamp; R. Alikhanov; H. Lang; A. Guglielmi; M. Cescon; W.R. Jarnagin; L. Aldrighetti; T.M. van Gulik; E. Sparrelid; Perihilar Cholangiocarcinoma Collaboration Group

doi:10.1016/j.hpb.2021.04.011

Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

H. Jansson^*
, P.B. Olthof
, A. Bergquist
, M.A.P. Ligthart
, S. Nadalin
, R.I. Troisi
, B.G. Koerkamp
, R. Alikhanov
, H. Lang
, A. Guglielmi
, M. Cescon
, W.R. Jarnagin
, L. Aldrighetti
, T.M. van Gulik
, E. Sparrelid
, Perihilar Cholangiocarcinoma Collaboration Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA. Methods: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000-2020). Patients operated with hepatobiliary resection, with pCCA verified by histology and with data on PSC status, were included. The primary outcome was overall survival. Secondary outcomes were disease-free survival and postoperative complications. Results: Of 1128 pCCA patients, 34 (3.0%) had underlying PSC. Median overall survival after resection was 33 months for PSC patients and 29 months for non-PSC patients (p = .630). Complications (ClavienDindo grade > 3) were more frequent in PSC pCCA (71% versus 44%, p = .003). The rate of posthepatectomy liver failure (21% versus 17%, p = .530) and 90-day mortality (12% versus 13%, p = 1.000) was similar for PSC and non-PSC patients. Conclusion: Median overall survival after resection for pCCA was similar in patients with underlying PSC and non-PSC patients. Complications were more frequent after resection for PSC-associated pCCA, with no difference in postoperative mortality.

Original language	English
Pages (from-to)	1751-1758
Number of pages	8
Journal	HPB
Volume	23
Issue number	11
DOIs	https://doi.org/10.1016/j.hpb.2021.04.011
Publication status	Published - 1 Nov 2021

Keywords

HILAR CHOLANGIOCARCINOMA
RISK

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Jansson, H., Olthof, P. B., Bergquist, A., Ligthart, M. A. P., Nadalin, S., Troisi, R. I., Koerkamp, B. G., Alikhanov, R., Lang, H., Guglielmi, A., Cescon, M., Jarnagin, W. R., Aldrighetti, L., van Gulik, T. M., Sparrelid, E., & Perihilar Cholangiocarcinoma Collaboration Group (2021). Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study. HPB, 23(11), 1751-1758. https://doi.org/10.1016/j.hpb.2021.04.011

@article{70a04c3d44484f5fab68558a809276c2,

title = "Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study",

abstract = "Background: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA. Methods: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000-2020). Patients operated with hepatobiliary resection, with pCCA verified by histology and with data on PSC status, were included. The primary outcome was overall survival. Secondary outcomes were disease-free survival and postoperative complications. Results: Of 1128 pCCA patients, 34 (3.0\%) had underlying PSC. Median overall survival after resection was 33 months for PSC patients and 29 months for non-PSC patients (p = .630). Complications (ClavienDindo grade > 3) were more frequent in PSC pCCA (71\% versus 44\%, p = .003). The rate of posthepatectomy liver failure (21\% versus 17\%, p = .530) and 90-day mortality (12\% versus 13\%, p = 1.000) was similar for PSC and non-PSC patients. Conclusion: Median overall survival after resection for pCCA was similar in patients with underlying PSC and non-PSC patients. Complications were more frequent after resection for PSC-associated pCCA, with no difference in postoperative mortality.",

keywords = "HILAR CHOLANGIOCARCINOMA, RISK",

author = "H. Jansson and P.B. Olthof and A. Bergquist and M.A.P. Ligthart and S. Nadalin and R.I. Troisi and B.G. Koerkamp and R. Alikhanov and H. Lang and A. Guglielmi and M. Cescon and W.R. Jarnagin and L. Aldrighetti and \{van Gulik\}, T.M. and E. Sparrelid and \{Perihilar Cholangiocarcinoma Collaboration Group\}",

note = "Funding Information: Hannes Jansson was supported by grants from the Royal Swedish Academy of Sciences and Region Stockholm . Ernesto Sparrelid was supported by grants from the Bengt Ihre Foundation , the Center for Innovative Medicine at Karolinska Institutet and Region Stockholm. The funding sources had no involvement in the design or conduct of the study, the writing of the report or the decision to submit the article for publication. Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = nov,

day = "1",

doi = "10.1016/j.hpb.2021.04.011",

language = "English",

volume = "23",

pages = "1751--1758",

journal = "HPB",

issn = "1365-182X",

publisher = "Elsevier B.V.",

number = "11",

}

Jansson, H, Olthof, PB, Bergquist, A, Ligthart, MAP, Nadalin, S, Troisi, RI, Koerkamp, BG, Alikhanov, R, Lang, H, Guglielmi, A, Cescon, M, Jarnagin, WR, Aldrighetti, L, van Gulik, TM, Sparrelid, E & Perihilar Cholangiocarcinoma Collaboration Group 2021, 'Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study', HPB, vol. 23, no. 11, pp. 1751-1758. https://doi.org/10.1016/j.hpb.2021.04.011

TY - JOUR

T1 - Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

AU - Jansson, H.

AU - Olthof, P.B.

AU - Bergquist, A.

AU - Ligthart, M.A.P.

AU - Nadalin, S.

AU - Troisi, R.I.

AU - Koerkamp, B.G.

AU - Alikhanov, R.

AU - Lang, H.

AU - Guglielmi, A.

AU - Cescon, M.

AU - Jarnagin, W.R.

AU - Aldrighetti, L.

AU - van Gulik, T.M.

AU - Sparrelid, E.

AU - Perihilar Cholangiocarcinoma Collaboration Group

N1 - Funding Information: Hannes Jansson was supported by grants from the Royal Swedish Academy of Sciences and Region Stockholm . Ernesto Sparrelid was supported by grants from the Bengt Ihre Foundation , the Center for Innovative Medicine at Karolinska Institutet and Region Stockholm. The funding sources had no involvement in the design or conduct of the study, the writing of the report or the decision to submit the article for publication. Publisher Copyright: © 2021 The Author(s)

PY - 2021/11/1

Y1 - 2021/11/1

N2 - Background: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA. Methods: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000-2020). Patients operated with hepatobiliary resection, with pCCA verified by histology and with data on PSC status, were included. The primary outcome was overall survival. Secondary outcomes were disease-free survival and postoperative complications. Results: Of 1128 pCCA patients, 34 (3.0%) had underlying PSC. Median overall survival after resection was 33 months for PSC patients and 29 months for non-PSC patients (p = .630). Complications (ClavienDindo grade > 3) were more frequent in PSC pCCA (71% versus 44%, p = .003). The rate of posthepatectomy liver failure (21% versus 17%, p = .530) and 90-day mortality (12% versus 13%, p = 1.000) was similar for PSC and non-PSC patients. Conclusion: Median overall survival after resection for pCCA was similar in patients with underlying PSC and non-PSC patients. Complications were more frequent after resection for PSC-associated pCCA, with no difference in postoperative mortality.

AB - Background: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA. Methods: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000-2020). Patients operated with hepatobiliary resection, with pCCA verified by histology and with data on PSC status, were included. The primary outcome was overall survival. Secondary outcomes were disease-free survival and postoperative complications. Results: Of 1128 pCCA patients, 34 (3.0%) had underlying PSC. Median overall survival after resection was 33 months for PSC patients and 29 months for non-PSC patients (p = .630). Complications (ClavienDindo grade > 3) were more frequent in PSC pCCA (71% versus 44%, p = .003). The rate of posthepatectomy liver failure (21% versus 17%, p = .530) and 90-day mortality (12% versus 13%, p = 1.000) was similar for PSC and non-PSC patients. Conclusion: Median overall survival after resection for pCCA was similar in patients with underlying PSC and non-PSC patients. Complications were more frequent after resection for PSC-associated pCCA, with no difference in postoperative mortality.

KW - HILAR CHOLANGIOCARCINOMA

KW - RISK

U2 - 10.1016/j.hpb.2021.04.011

DO - 10.1016/j.hpb.2021.04.011

M3 - Article

C2 - 33975797

SN - 1365-182X

VL - 23

SP - 1751

EP - 1758

JO - HPB

JF - HPB

IS - 11

ER -

Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

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