Osteophilic properties of bone implant surface modifications in a cassette model on a decorticated goat spinal transverse process

Bart A. J. A. van Oirschot, Rhandy M. Eman, Pamela Habibovic, Sander C. G. Leeuwenburgh, Zeinab Tahmasebi, Harrie Weinans, Jacqueline Alblas, Gert J. Meijer, John A. Jansen, Jeroen J. J. P. van den Beucken*

*Corresponding author for this work

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This study comparatively evaluated the osteophilic capacity of 17 different surface modifications (i.e. fourteen different chemical modifications via ceramic coatings and three different physical modifications via surface roughness) for titanium (Ti) surfaces. All surface modifications were subjected to physico-chemical analyses and immersion in simulated body fluid (SBF) for coating stability assessment. Subsequently, a bone conduction chamber cassette model on the goat transverse process was used for comparative in vivo analysis based on bone responses to these different surface modifications after twelve weeks. Histological and histomorphometrical analyses in terms of longitudinal bone-to-implant contact percentage (BIC%), relative bone area (BA%) were investigated within each individual channel and maximum bone height (BH). Characterization of the surface modifications showed significant differences in surface chemistry and surface roughness among the surface modifications. Generally, immersion of the coatings in SBF showed net uptake of calcium by thick coatings (>50?m; plasma-sprayed and biomimetic coatings) and no fluctuations in the SBF for thin coatings (
Original languageEnglish
Pages (from-to)195-205
JournalActa Biomaterialia
Publication statusPublished - Jun 2016


  • Biomaterials
  • Titanium implant
  • Surface modifications
  • Calcium phosphate
  • Goat model

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