Osteophilic properties of bone implant surface modifications in a cassette model on a decorticated goat spinal transverse process

Bart A. J. A. van Oirschot; Rhandy M. Eman; Pamela Habibovic; Sander C. G. Leeuwenburgh; Zeinab Tahmasebi; Harrie Weinans; Jacqueline Alblas; Gert J. Meijer; John A. Jansen; Jeroen J. J. P. van den Beucken

doi:10.1016/j.actbio.2016.03.037

Osteophilic properties of bone implant surface modifications in a cassette model on a decorticated goat spinal transverse process

Bart A. J. A. van Oirschot, Rhandy M. Eman, Pamela Habibovic, Sander C. G. Leeuwenburgh, Zeinab Tahmasebi, Harrie Weinans, Jacqueline Alblas, Gert J. Meijer, John A. Jansen, Jeroen J. J. P. van den Beucken^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This study comparatively evaluated the osteophilic capacity of 17 different surface modifications (i.e. fourteen different chemical modifications via ceramic coatings and three different physical modifications via surface roughness) for titanium (Ti) surfaces. All surface modifications were subjected to physico-chemical analyses and immersion in simulated body fluid (SBF) for coating stability assessment. Subsequently, a bone conduction chamber cassette model on the goat transverse process was used for comparative in vivo analysis based on bone responses to these different surface modifications after twelve weeks. Histological and histomorphometrical analyses in terms of longitudinal bone-to-implant contact percentage (BIC%), relative bone area (BA%) were investigated within each individual channel and maximum bone height (BH). Characterization of the surface modifications showed significant differences in surface chemistry and surface roughness among the surface modifications. Generally, immersion of the coatings in SBF showed net uptake of calcium by thick coatings (>50?m; plasma-sprayed and biomimetic coatings) and no fluctuations in the SBF for thin coatings (

Original language	English
Pages (from-to)	195-205
Journal	Acta Biomaterialia
Volume	37
DOIs	https://doi.org/10.1016/j.actbio.2016.03.037
Publication status	Published - Jun 2016

Keywords

Biomaterials
Titanium implant
Surface modifications
Calcium phosphate
Goat model

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10.1016/j.actbio.2016.03.037

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van Oirschot, B. A. J. A., Eman, R. M., Habibovic, P., Leeuwenburgh, S. C. G., Tahmasebi, Z., Weinans, H., Alblas, J., Meijer, G. J., Jansen, J. A., & van den Beucken, J. J. J. P. (2016). Osteophilic properties of bone implant surface modifications in a cassette model on a decorticated goat spinal transverse process. Acta Biomaterialia, 37, 195-205. https://doi.org/10.1016/j.actbio.2016.03.037

@article{7f75530da26242a0ad006dc41cd6970b,

title = "Osteophilic properties of bone implant surface modifications in a cassette model on a decorticated goat spinal transverse process",

abstract = "This study comparatively evaluated the osteophilic capacity of 17 different surface modifications (i.e. fourteen different chemical modifications via ceramic coatings and three different physical modifications via surface roughness) for titanium (Ti) surfaces. All surface modifications were subjected to physico-chemical analyses and immersion in simulated body fluid (SBF) for coating stability assessment. Subsequently, a bone conduction chamber cassette model on the goat transverse process was used for comparative in vivo analysis based on bone responses to these different surface modifications after twelve weeks. Histological and histomorphometrical analyses in terms of longitudinal bone-to-implant contact percentage (BIC%), relative bone area (BA%) were investigated within each individual channel and maximum bone height (BH). Characterization of the surface modifications showed significant differences in surface chemistry and surface roughness among the surface modifications. Generally, immersion of the coatings in SBF showed net uptake of calcium by thick coatings (>50?m; plasma-sprayed and biomimetic coatings) and no fluctuations in the SBF for thin coatings (",

keywords = "Biomaterials, Titanium implant, Surface modifications, Calcium phosphate, Goat model",

author = "{van Oirschot}, {Bart A. J. A.} and Eman, {Rhandy M.} and Pamela Habibovic and Leeuwenburgh, {Sander C. G.} and Zeinab Tahmasebi and Harrie Weinans and Jacqueline Alblas and Meijer, {Gert J.} and Jansen, {John A.} and {van den Beucken}, {Jeroen J. J. P.}",

year = "2016",

month = jun,

doi = "10.1016/j.actbio.2016.03.037",

language = "English",

volume = "37",

pages = "195--205",

journal = "Acta Biomaterialia",

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publisher = "Elsevier / Bunge",

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van Oirschot, BAJA, Eman, RM, Habibovic, P, Leeuwenburgh, SCG, Tahmasebi, Z, Weinans, H, Alblas, J, Meijer, GJ, Jansen, JA & van den Beucken, JJJP 2016, 'Osteophilic properties of bone implant surface modifications in a cassette model on a decorticated goat spinal transverse process', Acta Biomaterialia, vol. 37, pp. 195-205. https://doi.org/10.1016/j.actbio.2016.03.037

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T1 - Osteophilic properties of bone implant surface modifications in a cassette model on a decorticated goat spinal transverse process

AU - van Oirschot, Bart A. J. A.

AU - Eman, Rhandy M.

AU - Habibovic, Pamela

AU - Leeuwenburgh, Sander C. G.

AU - Tahmasebi, Zeinab

AU - Weinans, Harrie

AU - Alblas, Jacqueline

AU - Meijer, Gert J.

AU - Jansen, John A.

AU - van den Beucken, Jeroen J. J. P.

PY - 2016/6

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N2 - This study comparatively evaluated the osteophilic capacity of 17 different surface modifications (i.e. fourteen different chemical modifications via ceramic coatings and three different physical modifications via surface roughness) for titanium (Ti) surfaces. All surface modifications were subjected to physico-chemical analyses and immersion in simulated body fluid (SBF) for coating stability assessment. Subsequently, a bone conduction chamber cassette model on the goat transverse process was used for comparative in vivo analysis based on bone responses to these different surface modifications after twelve weeks. Histological and histomorphometrical analyses in terms of longitudinal bone-to-implant contact percentage (BIC%), relative bone area (BA%) were investigated within each individual channel and maximum bone height (BH). Characterization of the surface modifications showed significant differences in surface chemistry and surface roughness among the surface modifications. Generally, immersion of the coatings in SBF showed net uptake of calcium by thick coatings (>50?m; plasma-sprayed and biomimetic coatings) and no fluctuations in the SBF for thin coatings (

AB - This study comparatively evaluated the osteophilic capacity of 17 different surface modifications (i.e. fourteen different chemical modifications via ceramic coatings and three different physical modifications via surface roughness) for titanium (Ti) surfaces. All surface modifications were subjected to physico-chemical analyses and immersion in simulated body fluid (SBF) for coating stability assessment. Subsequently, a bone conduction chamber cassette model on the goat transverse process was used for comparative in vivo analysis based on bone responses to these different surface modifications after twelve weeks. Histological and histomorphometrical analyses in terms of longitudinal bone-to-implant contact percentage (BIC%), relative bone area (BA%) were investigated within each individual channel and maximum bone height (BH). Characterization of the surface modifications showed significant differences in surface chemistry and surface roughness among the surface modifications. Generally, immersion of the coatings in SBF showed net uptake of calcium by thick coatings (>50?m; plasma-sprayed and biomimetic coatings) and no fluctuations in the SBF for thin coatings (

KW - Biomaterials

KW - Titanium implant

KW - Surface modifications

KW - Calcium phosphate

KW - Goat model

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