Osteomyelitis can be a severe complication after elective or acute bone surgery and necessitates adequate surgical and antibiotic therapy. Golden standard surgical technique consists of a two-stage debridement with local antibiotics, set free from beads. Recent developments have led to an array of new biomaterials, like bioglas, that can be used in a one-stage fashion. Experience is growing and results are very promising. The golden standard might therefore become a one-stage procedure in the nearby future. This article gives some insight in the development, working mechanism and indications of the exciting biomaterial of bioactive glass.