Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT

B. S. van der Meij; J. A. E. Langius; M. D. Spreeuwenberg; S. M. Slootmaker; M. A. Paul; E. F. Smit; Paul A. M. van Leeuwen

doi:10.1038/ejcn.2011.214

Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT

B. S. van der Meij, J. A. E. Langius, M. D. Spreeuwenberg, S. M. Slootmaker, M. A. Paul, E. F. Smit, Paul A. M. van Leeuwen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Our objective was to investigate effects of an oral nutritional supplement containing n-3 polyunsaturated fatty acids (FAs) on quality of life, performance status, handgrip strength and physical activity in patients with non-small cell lung cancer (NSCLC) undergoing multimodality treatment.In a double-blind experiment, 40 patients with stage III NSCLC were randomised to receive 2 cans/day of a protein- and energy-dense oral nutritional supplement containing n-3 polyunsaturated FAs (2.02?g eicosapentaenoic acid+0.92?g docosahexaenoic acid/day) or an isocaloric control supplement, during multimodality treatment. Quality of life, Karnofsky Performance Status, handgrip strength and physical activity (by wearing an accelerometer) were assessed. Effects of intervention were analysed by generalised estimating equations. P-values

Original language	English
Pages (from-to)	399-404
Journal	European Journal of Clinical Nutrition
Volume	66
Issue number	3
DOIs	https://doi.org/10.1038/ejcn.2011.214
Publication status	Published - Mar 2012

Keywords

n-3 fatty acids
eicosapenaenoic acid
lung neoplasms
quality of life
RCT

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10.1038/ejcn.2011.214

Cite this

van der Meij, B. S., Langius, J. A. E., Spreeuwenberg, M. D., Slootmaker, S. M., Paul, M. A., Smit, E. F., & van Leeuwen, P. A. M. (2012). Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. European Journal of Clinical Nutrition, 66(3), 399-404. https://doi.org/10.1038/ejcn.2011.214

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title = "Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT",

abstract = "Our objective was to investigate effects of an oral nutritional supplement containing n-3 polyunsaturated fatty acids (FAs) on quality of life, performance status, handgrip strength and physical activity in patients with non-small cell lung cancer (NSCLC) undergoing multimodality treatment.In a double-blind experiment, 40 patients with stage III NSCLC were randomised to receive 2 cans/day of a protein- and energy-dense oral nutritional supplement containing n-3 polyunsaturated FAs (2.02?g eicosapentaenoic acid+0.92?g docosahexaenoic acid/day) or an isocaloric control supplement, during multimodality treatment. Quality of life, Karnofsky Performance Status, handgrip strength and physical activity (by wearing an accelerometer) were assessed. Effects of intervention were analysed by generalised estimating equations. P-values ",

keywords = "n-3 fatty acids, eicosapenaenoic acid, lung neoplasms, quality of life, RCT",

author = "{van der Meij}, {B. S.} and Langius, {J. A. E.} and Spreeuwenberg, {M. D.} and Slootmaker, {S. M.} and Paul, {M. A.} and Smit, {E. F.} and {van Leeuwen}, {Paul A. M.}",

year = "2012",

month = mar,

doi = "10.1038/ejcn.2011.214",

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van der Meij, BS, Langius, JAE, Spreeuwenberg, MD, Slootmaker, SM, Paul, MA, Smit, EF & van Leeuwen, PAM 2012, 'Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT', European Journal of Clinical Nutrition, vol. 66, no. 3, pp. 399-404. https://doi.org/10.1038/ejcn.2011.214

Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. / van der Meij, B. S.; Langius, J. A. E.; Spreeuwenberg, M. D. et al.

In: European Journal of Clinical Nutrition, Vol. 66, No. 3, 03.2012, p. 399-404.

Research output: Contribution to journal › Article › Academic › peer-review

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