Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT

B. S. van der Meij, J. A. E. Langius, M. D. Spreeuwenberg, S. M. Slootmaker, M. A. Paul, E. F. Smit, Paul A. M. van Leeuwen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Our objective was to investigate effects of an oral nutritional supplement containing n-3 polyunsaturated fatty acids (FAs) on quality of life, performance status, handgrip strength and physical activity in patients with non-small cell lung cancer (NSCLC) undergoing multimodality treatment.In a double-blind experiment, 40 patients with stage III NSCLC were randomised to receive 2 cans/day of a protein- and energy-dense oral nutritional supplement containing n-3 polyunsaturated FAs (2.02?g eicosapentaenoic acid+0.92?g docosahexaenoic acid/day) or an isocaloric control supplement, during multimodality treatment. Quality of life, Karnofsky Performance Status, handgrip strength and physical activity (by wearing an accelerometer) were assessed. Effects of intervention were analysed by generalised estimating equations. P-values
Original languageEnglish
Pages (from-to)399-404
JournalEuropean Journal of Clinical Nutrition
Volume66
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • n-3 fatty acids
  • eicosapenaenoic acid
  • lung neoplasms
  • quality of life
  • RCT

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