Optimizing patient care and research: the Amsterdam Dementia Cohort

Wiesje M van der Flier, Yolande A L Pijnenburg, Niels Prins, Afina W Lemstra, Femke H Bouwman, Charlotte E Teunissen, Bart N M van Berckel, Cornelis J Stam, Frederik Barkhof, Pieter Jelle Visser, Evan van Egmond, Philip Scheltens*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

240 Citations (Web of Science)


Since its opening in 2000, patient care and research go hand in hand at the Alzheimer center of the VU University Medical Center, both organized in such a way that they mutually strengthen each other. Our mission is to give patients a voice by lifting the stigma on dementia, to find new diagnostic and treatment strategies, and, ultimately, to cure diseases that cause dementia. Our healthcare pathway is uniquely designed to accommodate all necessary investigations for the diagnostic work-up of dementia in one day (one-stop shop). A second unique feature is that research has been fully integrated in the healthcare pathway. The resulting Amsterdam Dementia Cohort now includes over 4000 patients, and for the majority of these, we have MRI, EEG, blood (serum, plasma), DNA, and CSF available. The Amsterdam Dementia Cohort forms the basis of much of our research, which focuses on four major research lines: 1) variability in manifestation, 2) early diagnosis, 3) vascular factors, and 4) interventions. By answering research questions closely related to clinical practice, the results of our research can be looped back to improve clinical work-up for our patients.

Original languageEnglish
Pages (from-to)313-27
Number of pages15
JournalJournal of Alzheimer's Disease
Issue number1
Publication statusPublished - 2014


  • Academic Medical Centers
  • Aged
  • Alzheimer Disease
  • Biomedical Research
  • Cohort Studies
  • Critical Pathways
  • Dementia
  • Early Diagnosis
  • Female
  • Humans
  • Internet
  • Male
  • Middle Aged
  • Netherlands
  • Patient Care

Cite this