Optimization of placebos for double-blind clinical trials: Experience with a phytopharmaceutical

P.G. Knipschild, R. Hoerr*, R. Oschmann, E. van Rossum

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The maintenance of double-blind conditions in placebo-controlled trials depends on the quality of the placebo preparation. The placebo should match the active substance-containing preparation as closely as possible, but it must not contain any substances that might themselves be pharmacologically active. Active substances characterized by a particular colour, taste, smell or other easily perceptible properties constitute a challenge to researchers. The way of developing a placebo that matches a phytopharmaceutical to a satisfactory extent is described and discussed.

Publication Types:
Clinical Trial
Randomized Controlled Trial
Original languageEnglish
Pages (from-to)1033-1036
Number of pages4
JournalArzneimittelforschung : Drug Research
Issue number10
Publication statusPublished - 1 Jan 1998

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