TY - JOUR
T1 - Optimization of left ventricular pacing site plus multipoint pacing improves remodeling and clinical response to cardiac resynchronization therapy at 1 year
AU - Zanon, Francesco
AU - Marcantoni, Lina
AU - Baracca, Enrico
AU - Pastore, Gianni
AU - Lanza, Daniela
AU - Fraccaro, Chiara
AU - Picariello, Claudio
AU - Conte, Luca
AU - Aggio, Silvio
AU - Roncon, Loris
AU - Pacetta, Domenico
AU - Badie, Nima
AU - Noventa, Franco
AU - Prinzen, Frits W.
PY - 2016/8
Y1 - 2016/8
N2 - BACKGROUND Approximately one-third of the patients with heart failure (HF) treated with cardiac resynchronization therapy (CRT) fail to respond. Positioning the left ventricular (LV) pacing lead in the area of the latest electrical delay may improve the response to CRT. Multipoint pacing (MPP) of the LV has been shown to improve the acute hemodynamic response. OBJECTIVE The purpose of this study was to test the hypothesis that patients treated with MPP in whom LV pacing location is optimized have better long-term clinical outcomes than do patients treated with conventional CRT. METHODS We evaluated the echocardiographic and clinical response of 110 patients with HF treated for nearly 1 year with either conventional CRT (standard [STD] group, n = 54, 49%), CRT with hemodynamic and electrical optimization of the LV pacing site (optimized [OPT] group, n = 36, 33%), or OPT combined with MPP (OPT + MPP group, n = 20, 18%). Responders were classified in terms of reduction in end-systolic volume index >= 15%, reduction in New York Heart Association (NYHA) class >= 1, and Packer score variation (NYHA response with no HF-related hospitalization events or death). RESULTS In STD, OPT, and OPT + MPP groups, 56%, 72%, and 90% of patients, respectively, were end-systolic volume index responders (P =.004) and 67%, 78%, and 95% were NYHA class responders (P =.012); 59%, 67%, and 90% of patients exhibited a 1-year Packer score of 0 (P =.018). These trends remained significant after adjustment for confounding factors by multivariate logistic analysis. CONCLUSION Combining MPP with optimal positioning of the LV lead on the basis of electrical delay and hemodynamics enhances reverse remodeling and improves clinical outcomes beyond the effect due to conventional CRT.
AB - BACKGROUND Approximately one-third of the patients with heart failure (HF) treated with cardiac resynchronization therapy (CRT) fail to respond. Positioning the left ventricular (LV) pacing lead in the area of the latest electrical delay may improve the response to CRT. Multipoint pacing (MPP) of the LV has been shown to improve the acute hemodynamic response. OBJECTIVE The purpose of this study was to test the hypothesis that patients treated with MPP in whom LV pacing location is optimized have better long-term clinical outcomes than do patients treated with conventional CRT. METHODS We evaluated the echocardiographic and clinical response of 110 patients with HF treated for nearly 1 year with either conventional CRT (standard [STD] group, n = 54, 49%), CRT with hemodynamic and electrical optimization of the LV pacing site (optimized [OPT] group, n = 36, 33%), or OPT combined with MPP (OPT + MPP group, n = 20, 18%). Responders were classified in terms of reduction in end-systolic volume index >= 15%, reduction in New York Heart Association (NYHA) class >= 1, and Packer score variation (NYHA response with no HF-related hospitalization events or death). RESULTS In STD, OPT, and OPT + MPP groups, 56%, 72%, and 90% of patients, respectively, were end-systolic volume index responders (P =.004) and 67%, 78%, and 95% were NYHA class responders (P =.012); 59%, 67%, and 90% of patients exhibited a 1-year Packer score of 0 (P =.018). These trends remained significant after adjustment for confounding factors by multivariate logistic analysis. CONCLUSION Combining MPP with optimal positioning of the LV lead on the basis of electrical delay and hemodynamics enhances reverse remodeling and improves clinical outcomes beyond the effect due to conventional CRT.
KW - Heart failure
KW - Cardiac resynchronization therapy
KW - Multipoint pacing
KW - Hemodynamic response
KW - Left ventricular pacing
KW - Electrical delay
U2 - 10.1016/j.hrthm.2016.05.015
DO - 10.1016/j.hrthm.2016.05.015
M3 - Article
C2 - 27450156
SN - 1547-5271
VL - 13
SP - 1644
EP - 1651
JO - Heart Rhythm
JF - Heart Rhythm
IS - 8
ER -