Optimization of Bone Scaffold Porosity Distributions

Patrina S P Poh, Dvina Valainis, Kaushik Bhattacharya, Martijn van Griensven, Patrick Dondl*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Web of Science)

Abstract

Additive manufacturing (AM) is a rapidly emerging technology that has the potential to produce personalized scaffolds for tissue engineering applications with unprecedented control of structural and functional design. Particularly for bone defect regeneration, the complex coupling of biological mechanisms to the scaffolds' properties has led to a predominantly trial-and-error approach. To mitigate this, shape or topology optimization can be a useful tool to design a scaffold architecture that matches the desired design targets, albeit at high computational cost. Here, we consider an efficient macroscopic optimization routine based on a simple one-dimensional time-dependent model for bone regeneration in the presence of a bioresorbable polymer scaffold. The result of the optimization procedure is a scaffold porosity distribution which maximizes the stiffness of the scaffold and regenerated bone system over the entire regeneration time, so that the propensity for mechanical failure is minimized.

Original languageEnglish
Article number9170
Number of pages10
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 24 Jun 2019
Externally publishedYes

Keywords

  • CRITICAL-SIZED DEFECTS
  • PLATELET-RICH PLASMA
  • OPTIMAL-DESIGN
  • POLYCAPROLACTONE SCAFFOLD
  • TISSUE
  • ARCHITECTURE
  • MICROSTRUCTURE
  • RECONSTRUCTION
  • REGENERATION
  • DEGRADATION

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