Optimising mastectomy with a focus on skin and nipple-sparing approaches: a multidisciplinary point of view

Orit Kaidar-Person; Philip Poortmans; Birgitte Vrou Offersen; Icro Meattini; Trine Tramm; Petra Steyerova; David Dodwell; Jana de Boniface; Liesbeth J. Boersma

doi:10.1016/j.ejso.2025.110310

Optimising mastectomy with a focus on skin and nipple-sparing approaches: a multidisciplinary point of view

Orit Kaidar-Person^*
, Philip Poortmans
, Birgitte Vrou Offersen
, Icro Meattini
, Trine Tramm
, Petra Steyerova
, David Dodwell
, Jana de Boniface
, Liesbeth J. Boersma

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Mastectomy is indicated in approximately 15–30 % of breast cancer patients. Mastectomy drives the demand for breast reconstruction which is associated with an increased risk of surgical complications and in some reports poor local control. Postmastectomy irradiation is increasingly used in the context of breast reconstruction, which raises the risk of acute and late complications. Therefore, the purpose of this multidisciplinary narrative review is to provide insights into improving oncological and quality-of-life outcomes for patients undergoing mastectomy especially in combination with reconstruction.

Original language	English
Article number	110310
Number of pages	6
Journal	European Journal of Surgical Oncology
Volume	51
Issue number	10
DOIs	https://doi.org/10.1016/j.ejso.2025.110310
Publication status	Published - 1 Oct 2025

Keywords

Breast cancer
Margins
Mastectomy
Nipple sparing
Radiation
Radiotherapy
Skin sparing

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title = "Optimising mastectomy with a focus on skin and nipple-sparing approaches: a multidisciplinary point of view",

abstract = "Mastectomy is indicated in approximately 15–30 \% of breast cancer patients. Mastectomy drives the demand for breast reconstruction which is associated with an increased risk of surgical complications and in some reports poor local control. Postmastectomy irradiation is increasingly used in the context of breast reconstruction, which raises the risk of acute and late complications. Therefore, the purpose of this multidisciplinary narrative review is to provide insights into improving oncological and quality-of-life outcomes for patients undergoing mastectomy especially in combination with reconstruction.",

keywords = "Breast cancer, Margins, Mastectomy, Nipple sparing, Radiation, Radiotherapy, Skin sparing",

author = "Orit Kaidar-Person and Philip Poortmans and Offersen, \{Birgitte Vrou\} and Icro Meattini and Trine Tramm and Petra Steyerova and David Dodwell and \{de Boniface\}, Jana and Boersma, \{Liesbeth J.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

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doi = "10.1016/j.ejso.2025.110310",

language = "English",

volume = "51",

journal = "European Journal of Surgical Oncology",

issn = "0748-7983",

publisher = "W.B. Saunders Ltd",

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TY - JOUR

T1 - Optimising mastectomy with a focus on skin and nipple-sparing approaches

T2 - a multidisciplinary point of view

AU - Kaidar-Person, Orit

AU - Poortmans, Philip

AU - Offersen, Birgitte Vrou

AU - Meattini, Icro

AU - Tramm, Trine

AU - Steyerova, Petra

AU - Dodwell, David

AU - de Boniface, Jana

AU - Boersma, Liesbeth J.

PY - 2025/10/1

Y1 - 2025/10/1

N2 - Mastectomy is indicated in approximately 15–30 % of breast cancer patients. Mastectomy drives the demand for breast reconstruction which is associated with an increased risk of surgical complications and in some reports poor local control. Postmastectomy irradiation is increasingly used in the context of breast reconstruction, which raises the risk of acute and late complications. Therefore, the purpose of this multidisciplinary narrative review is to provide insights into improving oncological and quality-of-life outcomes for patients undergoing mastectomy especially in combination with reconstruction.

AB - Mastectomy is indicated in approximately 15–30 % of breast cancer patients. Mastectomy drives the demand for breast reconstruction which is associated with an increased risk of surgical complications and in some reports poor local control. Postmastectomy irradiation is increasingly used in the context of breast reconstruction, which raises the risk of acute and late complications. Therefore, the purpose of this multidisciplinary narrative review is to provide insights into improving oncological and quality-of-life outcomes for patients undergoing mastectomy especially in combination with reconstruction.

KW - Breast cancer

KW - Margins

KW - Mastectomy

KW - Nipple sparing

KW - Radiation

KW - Radiotherapy

KW - Skin sparing

U2 - 10.1016/j.ejso.2025.110310

DO - 10.1016/j.ejso.2025.110310

M3 - (Systematic) Review article

SN - 0748-7983

VL - 51

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

IS - 10

M1 - 110310

ER -

Optimising mastectomy with a focus on skin and nipple-sparing approaches: a multidisciplinary point of view

Abstract

Keywords

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