Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging

W. M. Freeze, D. N. ter Weele, W. M. Palm, R. W. van Hooren, E. Hoff, J. F. A. Jansen, H. I. L. Jacobs, F. R. Verhey, W. H. Backes*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Pericortical enhancement on postcontrast FLAIR images is a marker for subtle leptomeningeal blood-brain barrier leakage. We explored the optimal FLAIR sequence parameters for the detection of low gadolinium concentrations within the CSF. On the basis of phantom experiments and human in vivo data, we showed that detection of subtle pericortical enhancement can be facilitated by using a relatively long TE. Future studies should choose their FLAIR sequence parameters carefully when assessing pericortical enhancement due to subtle blood-brain barrier leakage.

Original languageEnglish
Pages (from-to)1481-1483
Number of pages3
JournalAmerican Journal of Neuroradiology
Issue number9
Publication statusPublished - Sept 2019



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