Optical Coherence Tomography Findings of Underlying Choroidal Neovascularization in Punctate Inner Choroidopathy

Aniruddha Agarwal; Sabia Handa; Alessandro Marchese; Salvatore Parrulli; Alessandro Invernizzi; Roel J Erckens; Tos T J M Berendschot; C A B Webers; Reema Bansal; Vishali Gupta

doi:10.3389/fmed.2021.758370

Optical Coherence Tomography Findings of Underlying Choroidal Neovascularization in Punctate Inner Choroidopathy

Aniruddha Agarwal^*, Sabia Handa, Alessandro Marchese, Salvatore Parrulli, Alessandro Invernizzi, Roel J Erckens, Tos T J M Berendschot, C A B Webers, Reema Bansal, Vishali Gupta

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: To analyze findings on optical coherence tomography (OCT) suggestive of choroidal neovascularization (CNV) in lesions of punctate inner choroidopathy (PIC). Methods: In this multi-center retrospective study, clinical data of patients with PIC were retrospectively analyzed. Quantitative data (height, width, and volume of PIC lesions), and qualitative data (disruption of ellipsoid zone (EZ)/Bruch's membrane (BM), outer retinal fuzziness, and choroidal back-shadowing) were compared between CNV+ and CNV- groups using Mann-Whitney U-test and Fischer's exact test. Results: In total, 35 eyes (29 patients; 21 women; mean age: 33.3 ± 6.5 years) were selected for analysis. Of the 35 PIC lesions studied, 17 had underlying CNV. Lesions with CNV+ had larger height, width, and volume (p < 0.001) and several distinctive features, such as disruption of EZ and BM, outer retinal fuzziness, and hypo-reflective back-shadowing (p < 0.001) compared with CNV-lesions. Conclusions: Quantitative and qualitative OCT analysis can aid in the prediction of an underlying CNV in the eyes with PIC.

Original language	English
Article number	758370
Number of pages	8
Journal	Frontiers in medicine
Volume	8
DOIs	https://doi.org/10.3389/fmed.2021.758370
Publication status	Published - 22 Dec 2021

Keywords

punctate inner choroidopathy
optical coherence tomography
choroidal neovascularization
optical coherence tomography angiography
uveitis
imaging
MACULAR DEGENERATION
AGE
ANGIOGRAPHY
SECONDARY
FEATURES

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Cite this

@article{ea010e55241b4797806feb19c1807ccf,

title = "Optical Coherence Tomography Findings of Underlying Choroidal Neovascularization in Punctate Inner Choroidopathy",

abstract = "Purpose: To analyze findings on optical coherence tomography (OCT) suggestive of choroidal neovascularization (CNV) in lesions of punctate inner choroidopathy (PIC). Methods: In this multi-center retrospective study, clinical data of patients with PIC were retrospectively analyzed. Quantitative data (height, width, and volume of PIC lesions), and qualitative data (disruption of ellipsoid zone (EZ)/Bruch's membrane (BM), outer retinal fuzziness, and choroidal back-shadowing) were compared between CNV+ and CNV- groups using Mann-Whitney U-test and Fischer's exact test. Results: In total, 35 eyes (29 patients; 21 women; mean age: 33.3 ± 6.5 years) were selected for analysis. Of the 35 PIC lesions studied, 17 had underlying CNV. Lesions with CNV+ had larger height, width, and volume (p < 0.001) and several distinctive features, such as disruption of EZ and BM, outer retinal fuzziness, and hypo-reflective back-shadowing (p < 0.001) compared with CNV-lesions. Conclusions: Quantitative and qualitative OCT analysis can aid in the prediction of an underlying CNV in the eyes with PIC.",

keywords = "punctate inner choroidopathy, optical coherence tomography, choroidal neovascularization, optical coherence tomography angiography, uveitis, imaging, MACULAR DEGENERATION, AGE, ANGIOGRAPHY, SECONDARY, FEATURES",

author = "Aniruddha Agarwal and Sabia Handa and Alessandro Marchese and Salvatore Parrulli and Alessandro Invernizzi and Erckens, {Roel J} and Berendschot, {Tos T J M} and Webers, {C A B} and Reema Bansal and Vishali Gupta",

note = "Copyright {\textcopyright} 2021 Agarwal, Handa, Marchese, Parrulli, Invernizzi, Erckens, Berendschot, Webers, Bansal and Gupta.",

year = "2021",

month = dec,

day = "22",

doi = "10.3389/fmed.2021.758370",

language = "English",

volume = "8",

journal = "Frontiers in medicine",

issn = "2296-858X",

publisher = "Frontiers Media S.A.",

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TY - JOUR

T1 - Optical Coherence Tomography Findings of Underlying Choroidal Neovascularization in Punctate Inner Choroidopathy

AU - Agarwal, Aniruddha

AU - Handa, Sabia

AU - Marchese, Alessandro

AU - Parrulli, Salvatore

AU - Invernizzi, Alessandro

AU - Erckens, Roel J

AU - Berendschot, Tos T J M

AU - Webers, C A B

AU - Bansal, Reema

AU - Gupta, Vishali

PY - 2021/12/22

Y1 - 2021/12/22

N2 - Purpose: To analyze findings on optical coherence tomography (OCT) suggestive of choroidal neovascularization (CNV) in lesions of punctate inner choroidopathy (PIC). Methods: In this multi-center retrospective study, clinical data of patients with PIC were retrospectively analyzed. Quantitative data (height, width, and volume of PIC lesions), and qualitative data (disruption of ellipsoid zone (EZ)/Bruch's membrane (BM), outer retinal fuzziness, and choroidal back-shadowing) were compared between CNV+ and CNV- groups using Mann-Whitney U-test and Fischer's exact test. Results: In total, 35 eyes (29 patients; 21 women; mean age: 33.3 ± 6.5 years) were selected for analysis. Of the 35 PIC lesions studied, 17 had underlying CNV. Lesions with CNV+ had larger height, width, and volume (p < 0.001) and several distinctive features, such as disruption of EZ and BM, outer retinal fuzziness, and hypo-reflective back-shadowing (p < 0.001) compared with CNV-lesions. Conclusions: Quantitative and qualitative OCT analysis can aid in the prediction of an underlying CNV in the eyes with PIC.

AB - Purpose: To analyze findings on optical coherence tomography (OCT) suggestive of choroidal neovascularization (CNV) in lesions of punctate inner choroidopathy (PIC). Methods: In this multi-center retrospective study, clinical data of patients with PIC were retrospectively analyzed. Quantitative data (height, width, and volume of PIC lesions), and qualitative data (disruption of ellipsoid zone (EZ)/Bruch's membrane (BM), outer retinal fuzziness, and choroidal back-shadowing) were compared between CNV+ and CNV- groups using Mann-Whitney U-test and Fischer's exact test. Results: In total, 35 eyes (29 patients; 21 women; mean age: 33.3 ± 6.5 years) were selected for analysis. Of the 35 PIC lesions studied, 17 had underlying CNV. Lesions with CNV+ had larger height, width, and volume (p < 0.001) and several distinctive features, such as disruption of EZ and BM, outer retinal fuzziness, and hypo-reflective back-shadowing (p < 0.001) compared with CNV-lesions. Conclusions: Quantitative and qualitative OCT analysis can aid in the prediction of an underlying CNV in the eyes with PIC.

KW - punctate inner choroidopathy

KW - optical coherence tomography

KW - choroidal neovascularization

KW - optical coherence tomography angiography

KW - uveitis

KW - imaging

KW - MACULAR DEGENERATION

KW - AGE

KW - ANGIOGRAPHY

KW - SECONDARY

KW - FEATURES

U2 - 10.3389/fmed.2021.758370

DO - 10.3389/fmed.2021.758370

M3 - Article

C2 - 35004727

SN - 2296-858X

VL - 8

JO - Frontiers in medicine

JF - Frontiers in medicine

M1 - 758370

ER -