Opposite effects of cannabis and cocaine on performance monitoring

Desirée B Spronk, Robbert J Verkes, Roshan Cools, Barbara Franke, Janelle H P Van Wel, Johannes G Ramaekers, Ellen R A De Bruijn

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Drug use is often associated with risky and unsafe behavior. However, the acute effects of cocaine and cannabis on performance monitoring processes have not been systematically investigated. The aim of the current study was to investigate how administration of these drugs alters performance monitoring processes, as reflected in the error-related negativity (ERN), the error positivity (Pe) and post-error slowing. A double-blind placebo-controlled randomized three-way crossover design was used. Sixty-one subjects completed a Flanker task while EEG measures were obtained. Subjects showed diminished ERN and Pe amplitudes after cannabis administration and increased ERN and Pe amplitudes after administration of cocaine. Neither drug affected post-error slowing. These results demonstrate diametrically opposing effects on the early and late phases of performance monitoring of the two most commonly used illicit drugs of abuse. Conversely, the behavioral adaptation phase of performance monitoring remained unaltered by the drugs.

Original languageEnglish
Pages (from-to)1127–1139
Number of pages13
JournalEuropean Neuropsychopharmacology
Volume26
Issue number7
DOIs
Publication statusPublished - Jul 2016

Keywords

  • Cannabis
  • Cocaine
  • Performance monitoring
  • Error-related negative
  • Error positivity
  • EVENT-RELATED POTENTIALS
  • HEALTHY-VOLUNTEERS
  • SELECTIVE ATTENTION
  • INHIBITORY CONTROL
  • RESPONSE CONFLICT
  • ANTISACCADE TASK
  • SEX-DIFFERENCES
  • ERROR
  • COMPONENTS
  • BRAIN

Cite this

Spronk, D. B., Verkes, R. J., Cools, R., Franke, B., Van Wel, J. H. P., Ramaekers, J. G., & De Bruijn, E. R. A. (2016). Opposite effects of cannabis and cocaine on performance monitoring. European Neuropsychopharmacology, 26(7), 1127–1139. https://doi.org/10.1016/j.euroneuro.2016.03.015