Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure

Yan Li; Lutgarde Thijs; Zhen-Yu Zhang; Kei Asayama; Tine W. Hansen; Jose Boggia; Kristina Bjoerklund-Bodegard; Wen-Yi Yang; Teemu J. Niiranen; Angeliki Ntineri; Fang-Fei Wei; Masahiro Kikuya; Takayoshi Ohkubo; Eamon Dolan; Atsushi Hozawa; Ichiro Tsuji; Katarzyna Stolarz-Skrzypek; Qi-Fang Huang; Jesus D. Melgarejo; Valerie Tikhonoff; Sofia Malyutina; Edoardo Casiglia; Yuri Nikitin; Lars Lind; Edgardo Sandoya; Lucas Aparicio; Jessica Barochiner; Natasza Gilis-Malinowska; Krzysztof Narkiewicz; Kalina Kawecka-Jaszcz; Gladys E. Maestre; Antti M. Jula; Jouni K. Johansson; Tatiana Kuznetsova; Jan Filipovsky; George Stergiou; Ji-Guang Wang; Yutaka Imai; Eoin O'Brien; Jan A. Staessen; International Database on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome Investigators

doi:10.1161/HYPERTENSIONAHA.119.12958

Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure

Yan Li
, Lutgarde Thijs
, Zhen-Yu Zhang
, Kei Asayama
, Tine W. Hansen
, Jose Boggia
, Kristina Bjoerklund-Bodegard
, Wen-Yi Yang
, Teemu J. Niiranen
, Angeliki Ntineri
, Fang-Fei Wei
, Masahiro Kikuya
, Takayoshi Ohkubo
, Eamon Dolan
, Atsushi Hozawa
, Ichiro Tsuji
, Katarzyna Stolarz-Skrzypek
, Qi-Fang Huang
, Jesus D. Melgarejo
, Valerie Tikhonoff

Sofia Malyutina, Edoardo Casiglia, Yuri Nikitin, Lars Lind, Edgardo Sandoya, Lucas Aparicio, Jessica Barochiner, Natasza Gilis-Malinowska, Krzysztof Narkiewicz, Kalina Kawecka-Jaszcz, Gladys E. Maestre, Antti M. Jula, Jouni K. Johansson, Tatiana Kuznetsova, Jan Filipovsky, George Stergiou, Ji-Guang Wang, Yutaka Imai, Eoin O'Brien, Jan A. Staessen^*, International Database on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome Investigators

^*Corresponding author for this work

Carim - Hypertension and target organ damage

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) blood pressure were measured in 17 921 participants (51.3% women; mean age, 54.2 years) from 17 population cohorts. Subsequently, mortality and cardiovascular events were recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (80 years). Over 236 491 person-years, 3855 people died and 2942 cardiovascular events occurred. From levels as low as 110/65 mm Hg, risk log-linearly increased with higher out-of-office systolic/diastolic blood pressure. From the youngest to the oldest age group, rates expressed per 1000 person-years increased (P

Original language	English
Pages (from-to)	1333-1342
Number of pages	10
Journal	Hypertension
Volume	74
Issue number	6
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.119.12958
Publication status	Published - Dec 2019

Keywords

BASE-LINE CHARACTERISTICS
CARDIOVASCULAR RISK
HOME
HYPERTENSION
INTERNATIONAL DATABASE
METAANALYSIS
MILLION ADULTS
MORTALITY
POPULATION
PREDICTION
STROKE
TASK-FORCE
ambulatory
blood pressure
blood pressure monitoring
cardiovascular diseases
hypertension
mortality

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10.1161/HYPERTENSIONAHA.119.12958

https://www.ncbi.nlm.nih.gov/pmc/articles/6854319Licence: Other

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Li, Y., Thijs, L., Zhang, Z.-Y., Asayama, K., Hansen, T. W., Boggia, J., Bjoerklund-Bodegard, K., Yang, W.-Y., Niiranen, T. J., Ntineri, A., Wei, F.-F., Kikuya, M., Ohkubo, T., Dolan, E., Hozawa, A., Tsuji, I., Stolarz-Skrzypek, K., Huang, Q.-F., Melgarejo, J. D., ... International Database on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome Investigators (2019). Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure. Hypertension, 74(6), 1333-1342. https://doi.org/10.1161/HYPERTENSIONAHA.119.12958

@article{b5279a6452c14ce7a747aaa78290f2be,

title = "Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure",

abstract = "Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) blood pressure were measured in 17 921 participants (51.3\% women; mean age, 54.2 years) from 17 population cohorts. Subsequently, mortality and cardiovascular events were recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (80 years). Over 236 491 person-years, 3855 people died and 2942 cardiovascular events occurred. From levels as low as 110/65 mm Hg, risk log-linearly increased with higher out-of-office systolic/diastolic blood pressure. From the youngest to the oldest age group, rates expressed per 1000 person-years increased (P",

keywords = "BASE-LINE CHARACTERISTICS, CARDIOVASCULAR RISK, HOME, HYPERTENSION, INTERNATIONAL DATABASE, METAANALYSIS, MILLION ADULTS, MORTALITY, POPULATION, PREDICTION, STROKE, TASK-FORCE, ambulatory, blood pressure, blood pressure monitoring, cardiovascular diseases, hypertension, mortality",

author = "Yan Li and Lutgarde Thijs and Zhen-Yu Zhang and Kei Asayama and Hansen, \{Tine W.\} and Jose Boggia and Kristina Bjoerklund-Bodegard and Wen-Yi Yang and Niiranen, \{Teemu J.\} and Angeliki Ntineri and Fang-Fei Wei and Masahiro Kikuya and Takayoshi Ohkubo and Eamon Dolan and Atsushi Hozawa and Ichiro Tsuji and Katarzyna Stolarz-Skrzypek and Qi-Fang Huang and Melgarejo, \{Jesus D.\} and Valerie Tikhonoff and Sofia Malyutina and Edoardo Casiglia and Yuri Nikitin and Lars Lind and Edgardo Sandoya and Lucas Aparicio and Jessica Barochiner and Natasza Gilis-Malinowska and Krzysztof Narkiewicz and Kalina Kawecka-Jaszcz and Maestre, \{Gladys E.\} and Jula, \{Antti M.\} and Johansson, \{Jouni K.\} and Tatiana Kuznetsova and Jan Filipovsky and George Stergiou and Ji-Guang Wang and Yutaka Imai and Eoin O'Brien and Staessen, \{Jan A.\} and \{International Database on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome Investigators\}",

note = "Publisher Copyright: {\textcopyright} 2019 American Heart Association, Inc.",

year = "2019",

month = dec,

doi = "10.1161/HYPERTENSIONAHA.119.12958",

language = "English",

volume = "74",

pages = "1333--1342",

journal = "Hypertension",

issn = "0194-911X",

publisher = "Lippincott Williams \& Wilkins",

number = "6",

}

Li, Y, Thijs, L, Zhang, Z-Y, Asayama, K, Hansen, TW, Boggia, J, Bjoerklund-Bodegard, K, Yang, W-Y, Niiranen, TJ, Ntineri, A, Wei, F-F, Kikuya, M, Ohkubo, T, Dolan, E, Hozawa, A, Tsuji, I, Stolarz-Skrzypek, K, Huang, Q-F, Melgarejo, JD, Tikhonoff, V, Malyutina, S, Casiglia, E, Nikitin, Y, Lind, L, Sandoya, E, Aparicio, L, Barochiner, J, Gilis-Malinowska, N, Narkiewicz, K, Kawecka-Jaszcz, K, Maestre, GE, Jula, AM, Johansson, JK, Kuznetsova, T, Filipovsky, J, Stergiou, G, Wang, J-G, Imai, Y, O'Brien, E, Staessen, JA & International Database on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome Investigators 2019, 'Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure', Hypertension, vol. 74, no. 6, pp. 1333-1342. https://doi.org/10.1161/HYPERTENSIONAHA.119.12958

TY - JOUR

T1 - Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure

AU - Li, Yan

AU - Thijs, Lutgarde

AU - Zhang, Zhen-Yu

AU - Asayama, Kei

AU - Hansen, Tine W.

AU - Boggia, Jose

AU - Bjoerklund-Bodegard, Kristina

AU - Yang, Wen-Yi

AU - Niiranen, Teemu J.

AU - Ntineri, Angeliki

AU - Wei, Fang-Fei

AU - Kikuya, Masahiro

AU - Ohkubo, Takayoshi

AU - Dolan, Eamon

AU - Hozawa, Atsushi

AU - Tsuji, Ichiro

AU - Stolarz-Skrzypek, Katarzyna

AU - Huang, Qi-Fang

AU - Melgarejo, Jesus D.

AU - Tikhonoff, Valerie

AU - Malyutina, Sofia

AU - Casiglia, Edoardo

AU - Nikitin, Yuri

AU - Lind, Lars

AU - Sandoya, Edgardo

AU - Aparicio, Lucas

AU - Barochiner, Jessica

AU - Gilis-Malinowska, Natasza

AU - Narkiewicz, Krzysztof

AU - Kawecka-Jaszcz, Kalina

AU - Maestre, Gladys E.

AU - Jula, Antti M.

AU - Johansson, Jouni K.

AU - Kuznetsova, Tatiana

AU - Filipovsky, Jan

AU - Stergiou, George

AU - Wang, Ji-Guang

AU - Imai, Yutaka

AU - O'Brien, Eoin

AU - Staessen, Jan A.

AU - International Database on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome Investigators

PY - 2019/12

Y1 - 2019/12

N2 - Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) blood pressure were measured in 17 921 participants (51.3% women; mean age, 54.2 years) from 17 population cohorts. Subsequently, mortality and cardiovascular events were recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (80 years). Over 236 491 person-years, 3855 people died and 2942 cardiovascular events occurred. From levels as low as 110/65 mm Hg, risk log-linearly increased with higher out-of-office systolic/diastolic blood pressure. From the youngest to the oldest age group, rates expressed per 1000 person-years increased (P

AB - Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or home (n=5297) blood pressure were measured in 17 921 participants (51.3% women; mean age, 54.2 years) from 17 population cohorts. Subsequently, mortality and cardiovascular events were recorded. Using multivariable Cox regression, floating absolute risk was computed across 4 age bands (80 years). Over 236 491 person-years, 3855 people died and 2942 cardiovascular events occurred. From levels as low as 110/65 mm Hg, risk log-linearly increased with higher out-of-office systolic/diastolic blood pressure. From the youngest to the oldest age group, rates expressed per 1000 person-years increased (P

KW - BASE-LINE CHARACTERISTICS

KW - CARDIOVASCULAR RISK

KW - HOME

KW - HYPERTENSION

KW - INTERNATIONAL DATABASE

KW - METAANALYSIS

KW - MILLION ADULTS

KW - MORTALITY

KW - POPULATION

KW - PREDICTION

KW - STROKE

KW - TASK-FORCE

KW - ambulatory

KW - blood pressure

KW - blood pressure monitoring

KW - cardiovascular diseases

KW - hypertension

KW - mortality

U2 - 10.1161/HYPERTENSIONAHA.119.12958

DO - 10.1161/HYPERTENSIONAHA.119.12958

M3 - Article

C2 - 31630575

SN - 0194-911X

VL - 74

SP - 1333

EP - 1342

JO - Hypertension

JF - Hypertension

IS - 6

ER -

Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure

Abstract

Keywords

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