Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach

Mario F. Gaudino, Roberto Lorusso, Lucas B. Ohmes, Navneet Narula, Patrick McIntire, Antonella Gargiulo, Maria Rosaria Bucci, Jeremy Leonard, Mohamed Rahouma, Antonino Di Franco, Guo-Wei He, Leonard N. Girardi, Robert F. Tranbaugh, Annarita Di Lorenzo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Web of Science)

Abstract

OBJECTIVES: Both the open and endovascular techniques are commonly used for harvesting the radial artery (ORAH and ERAH, respectively), and yet, very little is known about the effects of these 2 techniques on endothelial integrity and function of the radial artery (RA). The aim of this study was to assess the endothelial integrity and function of RA harvested using the 2 approaches.

METHODS: Two independent surgical teams working in the same institution routinely use the RA for coronary artery bypass grafting exclusively employing either ORAH or ERAH. Thirty-nine consecutive patients were enrolled in this comparative study. Endothelial function after ORAH or ERAH was assessed by using the wire myograph system. The integrity of the RA endothelium was evaluated by immunohistochemical staining for erythroblast transformation specific-related gene.

RESULTS: The vasodilation in response to acetylcholine was significantly higher in RA harvested with ORAH (P

CONCLUSIONS: ORAH is associated with a significantly higher endothelium-dependent vasodilation. Further investigation on the potential implications of these findings in terms of graft spasm and patency as well as clinical outcomes are needed.

Original languageEnglish
Pages (from-to)561-567
Number of pages7
JournalInteractive Cardiovascular and Thoracic Surgery
Volume29
Issue number4
DOIs
Publication statusPublished - Oct 2019
Event32nd Annual Meeting of the European-Association-for-Cardio-Thoracic-Surgery - Milan, Italy
Duration: 18 Oct 201820 Oct 2018

Keywords

  • Radial artery
  • Coronary artery bypass grafting
  • Open harvesting
  • Endoscopic harvesting
  • Endothelium
  • CORONARY-ARTERY
  • SAPHENOUS-VEIN
  • PATENCY

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