Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach

Mario F. Gaudino; Roberto Lorusso; Lucas B. Ohmes; Navneet Narula; Patrick McIntire; Antonella Gargiulo; Maria Rosaria Bucci; Jeremy Leonard; Mohamed Rahouma; Antonino Di Franco; Guo-Wei He; Leonard N. Girardi; Robert F. Tranbaugh; Annarita Di Lorenzo

doi:10.1093/icvts/ivz129

Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach

Mario F. Gaudino, Roberto Lorusso, Lucas B. Ohmes, Navneet Narula, Patrick McIntire, Antonella Gargiulo, Maria Rosaria Bucci, Jeremy Leonard, Mohamed Rahouma, Antonino Di Franco, Guo-Wei He, Leonard N. Girardi, Robert F. Tranbaugh, Annarita Di Lorenzo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: Both the open and endovascular techniques are commonly used for harvesting the radial artery (ORAH and ERAH, respectively), and yet, very little is known about the effects of these 2 techniques on endothelial integrity and function of the radial artery (RA). The aim of this study was to assess the endothelial integrity and function of RA harvested using the 2 approaches.

METHODS: Two independent surgical teams working in the same institution routinely use the RA for coronary artery bypass grafting exclusively employing either ORAH or ERAH. Thirty-nine consecutive patients were enrolled in this comparative study. Endothelial function after ORAH or ERAH was assessed by using the wire myograph system. The integrity of the RA endothelium was evaluated by immunohistochemical staining for erythroblast transformation specific-related gene.

RESULTS: The vasodilation in response to acetylcholine was significantly higher in RA harvested with ORAH (P

CONCLUSIONS: ORAH is associated with a significantly higher endothelium-dependent vasodilation. Further investigation on the potential implications of these findings in terms of graft spasm and patency as well as clinical outcomes are needed.

Original language	English
Pages (from-to)	561-567
Number of pages	7
Journal	Interactive Cardiovascular and Thoracic Surgery
Volume	29
Issue number	4
DOIs	https://doi.org/10.1093/icvts/ivz129
Publication status	Published - Oct 2019
Event	32nd Annual Meeting of the European-Association-for-Cardio-Thoracic-Surgery - Milan, Italy Duration: 18 Oct 2018 → 20 Oct 2018

Keywords

Radial artery
Coronary artery bypass grafting
Open harvesting
Endoscopic harvesting
Endothelium
CORONARY-ARTERY
SAPHENOUS-VEIN
PATENCY

Access to Document

10.1093/icvts/ivz129

Cite this

Gaudino, M. F., Lorusso, R., Ohmes, L. B., Narula, N., McIntire, P., Gargiulo, A., Bucci, M. R., Leonard, J., Rahouma, M., Di Franco, A., He, G.-W., Girardi, L. N., Tranbaugh, R. F., & Di Lorenzo, A. (2019). Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach. Interactive Cardiovascular and Thoracic Surgery, 29(4), 561-567. https://doi.org/10.1093/icvts/ivz129

@article{67a9b652201342d995c0fb4dabfd06e4,

title = "Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach",

abstract = "OBJECTIVES: Both the open and endovascular techniques are commonly used for harvesting the radial artery (ORAH and ERAH, respectively), and yet, very little is known about the effects of these 2 techniques on endothelial integrity and function of the radial artery (RA). The aim of this study was to assess the endothelial integrity and function of RA harvested using the 2 approaches.METHODS: Two independent surgical teams working in the same institution routinely use the RA for coronary artery bypass grafting exclusively employing either ORAH or ERAH. Thirty-nine consecutive patients were enrolled in this comparative study. Endothelial function after ORAH or ERAH was assessed by using the wire myograph system. The integrity of the RA endothelium was evaluated by immunohistochemical staining for erythroblast transformation specific-related gene.RESULTS: The vasodilation in response to acetylcholine was significantly higher in RA harvested with ORAH (PCONCLUSIONS: ORAH is associated with a significantly higher endothelium-dependent vasodilation. Further investigation on the potential implications of these findings in terms of graft spasm and patency as well as clinical outcomes are needed.",

keywords = "Radial artery, Coronary artery bypass grafting, Open harvesting, Endoscopic harvesting, Endothelium, CORONARY-ARTERY, SAPHENOUS-VEIN, PATENCY",

author = "Gaudino, {Mario F.} and Roberto Lorusso and Ohmes, {Lucas B.} and Navneet Narula and Patrick McIntire and Antonella Gargiulo and Bucci, {Maria Rosaria} and Jeremy Leonard and Mohamed Rahouma and {Di Franco}, Antonino and Guo-Wei He and Girardi, {Leonard N.} and Tranbaugh, {Robert F.} and {Di Lorenzo}, Annarita",

note = "Funding Information: This work was supported by a grant from the Weill Cornell Clinical and Translational Science Centre to M.F.G. and National Institutes of Health [grant R01HL126913 to A.D.L.]. Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.; 32nd Annual Meeting of the European-Association-for-Cardio-Thoracic-Surgery ; Conference date: 18-10-2018 Through 20-10-2018",

year = "2019",

month = oct,

doi = "10.1093/icvts/ivz129",

language = "English",

volume = "29",

pages = "561--567",

journal = "Interactive Cardiovascular and Thoracic Surgery",

issn = "1569-9293",

publisher = "Oxford University Press",

number = "4",

}

Gaudino, MF, Lorusso, R, Ohmes, LB, Narula, N, McIntire, P, Gargiulo, A, Bucci, MR, Leonard, J, Rahouma, M, Di Franco, A, He, G-W, Girardi, LN, Tranbaugh, RF & Di Lorenzo, A 2019, 'Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach', Interactive Cardiovascular and Thoracic Surgery, vol. 29, no. 4, pp. 561-567. https://doi.org/10.1093/icvts/ivz129

TY - JOUR

T1 - Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach

AU - Gaudino, Mario F.

AU - Lorusso, Roberto

AU - Ohmes, Lucas B.

AU - Narula, Navneet

AU - McIntire, Patrick

AU - Gargiulo, Antonella

AU - Bucci, Maria Rosaria

AU - Leonard, Jeremy

AU - Rahouma, Mohamed

AU - Di Franco, Antonino

AU - He, Guo-Wei

AU - Girardi, Leonard N.

AU - Tranbaugh, Robert F.

AU - Di Lorenzo, Annarita

N1 - Funding Information: This work was supported by a grant from the Weill Cornell Clinical and Translational Science Centre to M.F.G. and National Institutes of Health [grant R01HL126913 to A.D.L.]. Publisher Copyright: © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

PY - 2019/10

Y1 - 2019/10

N2 - OBJECTIVES: Both the open and endovascular techniques are commonly used for harvesting the radial artery (ORAH and ERAH, respectively), and yet, very little is known about the effects of these 2 techniques on endothelial integrity and function of the radial artery (RA). The aim of this study was to assess the endothelial integrity and function of RA harvested using the 2 approaches.METHODS: Two independent surgical teams working in the same institution routinely use the RA for coronary artery bypass grafting exclusively employing either ORAH or ERAH. Thirty-nine consecutive patients were enrolled in this comparative study. Endothelial function after ORAH or ERAH was assessed by using the wire myograph system. The integrity of the RA endothelium was evaluated by immunohistochemical staining for erythroblast transformation specific-related gene.RESULTS: The vasodilation in response to acetylcholine was significantly higher in RA harvested with ORAH (PCONCLUSIONS: ORAH is associated with a significantly higher endothelium-dependent vasodilation. Further investigation on the potential implications of these findings in terms of graft spasm and patency as well as clinical outcomes are needed.

AB - OBJECTIVES: Both the open and endovascular techniques are commonly used for harvesting the radial artery (ORAH and ERAH, respectively), and yet, very little is known about the effects of these 2 techniques on endothelial integrity and function of the radial artery (RA). The aim of this study was to assess the endothelial integrity and function of RA harvested using the 2 approaches.METHODS: Two independent surgical teams working in the same institution routinely use the RA for coronary artery bypass grafting exclusively employing either ORAH or ERAH. Thirty-nine consecutive patients were enrolled in this comparative study. Endothelial function after ORAH or ERAH was assessed by using the wire myograph system. The integrity of the RA endothelium was evaluated by immunohistochemical staining for erythroblast transformation specific-related gene.RESULTS: The vasodilation in response to acetylcholine was significantly higher in RA harvested with ORAH (PCONCLUSIONS: ORAH is associated with a significantly higher endothelium-dependent vasodilation. Further investigation on the potential implications of these findings in terms of graft spasm and patency as well as clinical outcomes are needed.

KW - Radial artery

KW - Coronary artery bypass grafting

KW - Open harvesting

KW - Endoscopic harvesting

KW - Endothelium

KW - CORONARY-ARTERY

KW - SAPHENOUS-VEIN

KW - PATENCY

U2 - 10.1093/icvts/ivz129

DO - 10.1093/icvts/ivz129

M3 - Article

C2 - 31157868

SN - 1569-9293

VL - 29

SP - 561

EP - 567

JO - Interactive Cardiovascular and Thoracic Surgery

JF - Interactive Cardiovascular and Thoracic Surgery

IS - 4

T2 - 32nd Annual Meeting of the European-Association-for-Cardio-Thoracic-Surgery

Y2 - 18 October 2018 through 20 October 2018

ER -