TY - JOUR
T1 - One-year outcomes in COVID-19 and non-COVID-19 intensive care unit survivors
AU - Heesakkers, Hidde
AU - van der Hoeven, Johannes G.
AU - Corsten, Stijn
AU - Janssen, Inge
AU - Ewalds, Esther
AU - Simons, Koen S.
AU - de Blauw, Maaike
AU - Rettig, Thijs C. D.
AU - Jacobs, Cretien
AU - van Santen, Susanne
AU - Slooter, Arjen J. C.
AU - van der Woude, Margaretha C. E.
AU - Zegers, Marieke
AU - van den Boogaard, Mark
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Purpose: To determine differences in one-year multi-domain health outcomes in COVID-19 and non-COVID-19 intensive care unit (ICU) survivors. Materials and methods: Adult ICU survivors treated for COVID-19 were compared to a control group consisting of survivors admitted for respiratory distress due to other causes, i.e. non-COVID-19 ARDS or pneumonia. Occurrence of physical (frailty, fatigue, physical symptoms), mental (anxiety, depression, post-traumatic stress) and cognitive symptoms, and quality of life (QoL) scores were measured, using validated questionnaires, before and one year after ICU treatment. Results: In total, 506 COVID-19 survivors could be compared to 228 non-COVID-19 survivors. At one-year followup, COVID-19 ICU survivors had less physical (76.2% vs. 86.9%, p = 0.001) and mental symptoms (32.0% vs. 47.1%, p < 0.001) than the control group. Cognitive symptoms were comparable (22.5% vs. 17.2%, p = 0.12). However, compared to pre-ICU health symptoms and scores, COVID-19 survivors experienced an increase in symptom occurrence rates in all domains and a decrease in QoL, whereas the control group only experienced an increase in mental and cognitive symptoms, with a similar QoL at one-year follow-up. Conclusions: COVID-19 ICU survivors experience equal or less health problems but a greater decline in QoL one year after ICU admission compared to non-COVID-19 ARDS or pneumonia survivors.
AB - Purpose: To determine differences in one-year multi-domain health outcomes in COVID-19 and non-COVID-19 intensive care unit (ICU) survivors. Materials and methods: Adult ICU survivors treated for COVID-19 were compared to a control group consisting of survivors admitted for respiratory distress due to other causes, i.e. non-COVID-19 ARDS or pneumonia. Occurrence of physical (frailty, fatigue, physical symptoms), mental (anxiety, depression, post-traumatic stress) and cognitive symptoms, and quality of life (QoL) scores were measured, using validated questionnaires, before and one year after ICU treatment. Results: In total, 506 COVID-19 survivors could be compared to 228 non-COVID-19 survivors. At one-year followup, COVID-19 ICU survivors had less physical (76.2% vs. 86.9%, p = 0.001) and mental symptoms (32.0% vs. 47.1%, p < 0.001) than the control group. Cognitive symptoms were comparable (22.5% vs. 17.2%, p = 0.12). However, compared to pre-ICU health symptoms and scores, COVID-19 survivors experienced an increase in symptom occurrence rates in all domains and a decrease in QoL, whereas the control group only experienced an increase in mental and cognitive symptoms, with a similar QoL at one-year follow-up. Conclusions: COVID-19 ICU survivors experience equal or less health problems but a greater decline in QoL one year after ICU admission compared to non-COVID-19 ARDS or pneumonia survivors.
KW - Critical care outcomes
KW - Critical illness
KW - COVID-19
KW - Respiratory distress syndrome
KW - Quality of life
KW - HOSPITAL ANXIETY
KW - DEPRESSION SCALE
KW - RECOVERY
KW - FRAILTY
U2 - 10.1016/j.jcrc.2024.154858
DO - 10.1016/j.jcrc.2024.154858
M3 - Article
SN - 0883-9441
VL - 84
JO - Journal of Critical Care
JF - Journal of Critical Care
M1 - 154858
ER -