One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

Lena Bilet, Esther Phielix, Tineke van de Weijer, Anne Gemmink, Madeleen Bosma, Esther Moonen-Kornips, Johanna A. Jorgensen, Gert Schaart, Dongyan Zhang, Kenneth Meijer, Maria Hopman, Matthijs K. C. Hesselink, D. Margriet Ouwens, Gerald I. Shulman, Vera B. Schrauwen-Hinderling, Patrick Schrauwen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1211-1222
Number of pages12
JournalDiabetologia
Volume63
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Fat oxidation
  • Insulin resistance
  • Intramyocellular lipid content
  • Mitochondrial function
  • Mitochondrial oxidative capacity
  • Physical inactivity
  • Unilateral lower-limb suspension
  • SKELETAL-MUSCLE
  • PHYSICAL INACTIVITY
  • SKIN TEMPERATURE
  • FATTY-ACIDS
  • ECTOPIC FAT
  • PKC-THETA
  • RESISTANCE
  • DYSFUNCTION
  • EXERCISE
  • AGE

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