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Omniligase-1: A Powerful Tool for Peptide Head-to-Tail Cyclization
Marcel Schmidt
, Ana Toplak
, Peter J. L. M. Quaedflieg
,
Hans Ippel
, Gaston J. J. Richelle
,
Tilman M. Hackeng
, Jan H. van Maarseveen
, Timo Nuijens
*
*
Corresponding author for this work
Biochemie
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Keyphrases
Head-to-tail Cyclization
100%
Omniligase-1
100%
Amino Acids
75%
Cyclization
75%
Cyclotides
75%
Side Chain
25%
Kinase Inhibitor
25%
D-amino Acids
25%
Polyethylene Glycol
25%
Oxidative Folding
25%
Ring Width
25%
Gram-scale
25%
Macrocycles
25%
NMR Structure Determination
25%
One-pot Reaction
25%
Peptide Macrocycles
25%
Peptide Cyclization
25%
Isopeptide Bond
25%
Minimal Rings
25%
Cyclic Peptide
25%
Multicyclic
25%
Peptide Ligase
25%
Chemical Ligation
25%
Chemoenzymatic Synthesis
25%
Efficient Synthesis
25%
Disulfide Bond Pattern
25%
INIS
tools
100%
peptides
100%
cyclization
100%
amino acids
44%
synthesis
22%
size
11%
efficiency
11%
kinases
11%
bonding
11%
nmr
11%
compatibility
11%
oxidation
11%
rings
11%
disulfides
11%
ligases
11%
polyethylene glycols
11%
Chemistry
Structure Determination
25%