Omics technologies to understand drug toxicity mechanisms

Nhan Nguyen; Danyel Jennen; Jos Kleinjans

doi:10.1016/j.drudis.2022.103348

Omics technologies to understand drug toxicity mechanisms

Nhan Nguyen, Danyel Jennen^*, Jos Kleinjans

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Drug side effects are an important study subject in pharmacology. Recent omics technologies provide a range of omics data and help to understand the biological mechanisms involved in drug effects. These modern technologies provide significant support to all biological disciplines, including drug toxicology. In this review, we provide an overview the use of omics applications to understand drug side effects at the molecular level. We discuss by available omics technologies, their possible uses, as well as their advantages and limitations.

Original language	English
Article number	103348
Number of pages	7
Journal	Drug Discovery Today
Volume	27
Issue number	11
Early online date	8 Sept 2022
DOIs	https://doi.org/10.1016/j.drudis.2022.103348
Publication status	Published - Nov 2022

Access to Document

10.1016/j.drudis.2022.103348Licence: CC BY-NC-ND

Cite this

@article{1c53c5907c914adfaacd8a1d306661d6,

title = "Omics technologies to understand drug toxicity mechanisms",

abstract = "Drug side effects are an important study subject in pharmacology. Recent omics technologies provide a range of omics data and help to understand the biological mechanisms involved in drug effects. These modern technologies provide significant support to all biological disciplines, including drug toxicology. In this review, we provide an overview the use of omics applications to understand drug side effects at the molecular level. We discuss by available omics technologies, their possible uses, as well as their advantages and limitations.",

author = "Nhan Nguyen and Danyel Jennen and Jos Kleinjans",

year = "2022",

month = nov,

doi = "10.1016/j.drudis.2022.103348",

language = "English",

volume = "27",

journal = "Drug Discovery Today",

issn = "1359-6446",

publisher = "Elsevier Limited",

number = "11",

}

TY - JOUR

T1 - Omics technologies to understand drug toxicity mechanisms

AU - Nguyen, Nhan

AU - Jennen, Danyel

AU - Kleinjans, Jos

PY - 2022/11

Y1 - 2022/11

N2 - Drug side effects are an important study subject in pharmacology. Recent omics technologies provide a range of omics data and help to understand the biological mechanisms involved in drug effects. These modern technologies provide significant support to all biological disciplines, including drug toxicology. In this review, we provide an overview the use of omics applications to understand drug side effects at the molecular level. We discuss by available omics technologies, their possible uses, as well as their advantages and limitations.

AB - Drug side effects are an important study subject in pharmacology. Recent omics technologies provide a range of omics data and help to understand the biological mechanisms involved in drug effects. These modern technologies provide significant support to all biological disciplines, including drug toxicology. In this review, we provide an overview the use of omics applications to understand drug side effects at the molecular level. We discuss by available omics technologies, their possible uses, as well as their advantages and limitations.

U2 - 10.1016/j.drudis.2022.103348

DO - 10.1016/j.drudis.2022.103348

M3 - (Systematic) Review article

C2 - 36089240

SN - 1359-6446

VL - 27

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 11

M1 - 103348

ER -