Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

J. Jiang; K. Mathijs; L. Timmermans; S. M. Claessen; A. Hecka; J. Weusten; R. Peters; J. H. van Delft; J. C. S. Kleinjans; D. G. J. Jennen; T. M. de Kok

doi:10.1016/j.taap.2017.07.014

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

J. Jiang^*, K. Mathijs, L. Timmermans, S. M. Claessen, A. Hecka, J. Weusten, R. Peters, J. H. van Delft, J. C. S. Kleinjans, D. G. J. Jennen, T. M. de Kok

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	100-108
Number of pages	9
Journal	Toxicology and Applied Pharmacology
Volume	332
DOIs	https://doi.org/10.1016/j.taap.2017.07.014
Publication status	Published - 1 Oct 2017

Keywords

Drug-induced liver injury
Microarray
Toxicogenomics
Ceramide
ER stress
Apoptosis
NECROSIS-FACTOR-ALPHA
INDUCED CELL-DEATH
JNK ACTIVATION
HEPG2 CELLS
PROTEOMICS INVESTIGATIONS
INDUCED HEPATOTOXICITY
HUMAN HEPATOCYTES
PROTEIN-KINASES
CERAMIDE
APOPTOSIS

Cite this

Jiang, J., Mathijs, K., Timmermans, L., Claessen, S. M., Hecka, A., Weusten, J., Peters, R., van Delft, J. H., Kleinjans, J. C. S., Jennen, D. G. J., & de Kok, T. M. (2017). Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury. Toxicology and Applied Pharmacology, 332, 100-108. https://doi.org/10.1016/j.taap.2017.07.014

Jiang, J. ; Mathijs, K. ; Timmermans, L. ; Claessen, S. M. ; Hecka, A. ; Weusten, J. ; Peters, R. ; van Delft, J. H. ; Kleinjans, J. C. S. ; Jennen, D. G. J. ; de Kok, T. M. / Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury. In: Toxicology and Applied Pharmacology. 2017 ; Vol. 332. pp. 100-108.

@article{68f2bdfe28464416ad863f93cee315bf,

title = "Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury",

keywords = "Drug-induced liver injury, Microarray, Toxicogenomics, Ceramide, ER stress, Apoptosis, NECROSIS-FACTOR-ALPHA, INDUCED CELL-DEATH, JNK ACTIVATION, HEPG2 CELLS, PROTEOMICS INVESTIGATIONS, INDUCED HEPATOTOXICITY, HUMAN HEPATOCYTES, PROTEIN-KINASES, CERAMIDE, APOPTOSIS",

author = "J. Jiang and K. Mathijs and L. Timmermans and Claessen, {S. M.} and A. Hecka and J. Weusten and R. Peters and {van Delft}, {J. H.} and Kleinjans, {J. C. S.} and Jennen, {D. G. J.} and {de Kok}, {T. M.}",

year = "2017",

month = oct

day = "1",

doi = "10.1016/j.taap.2017.07.014",

language = "English",

volume = "332",

pages = "100--108",

journal = "Toxicology and Applied Pharmacology",

issn = "0041-008X",

publisher = "Elsevier Science",

}

Jiang, J, Mathijs, K, Timmermans, L, Claessen, SM, Hecka, A, Weusten, J, Peters, R, van Delft, JH, Kleinjans, JCS , Jennen, DGJ & de Kok, TM 2017, 'Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury', Toxicology and Applied Pharmacology, vol. 332, pp. 100-108. https://doi.org/10.1016/j.taap.2017.07.014

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury. / Jiang, J.; Mathijs, K.; Timmermans, L.; Claessen, S. M.; Hecka, A.; Weusten, J.; Peters, R.; van Delft, J. H.; Kleinjans, J. C. S.; Jennen, D. G. J.; de Kok, T. M.

In: Toxicology and Applied Pharmacology, Vol. 332, 01.10.2017, p. 100-108.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

AU - Jiang, J.

AU - Mathijs, K.

AU - Timmermans, L.

AU - Claessen, S. M.

AU - Hecka, A.

AU - Weusten, J.

AU - Peters, R.

AU - van Delft, J. H.

AU - Kleinjans, J. C. S.

AU - Jennen, D. G. J.

AU - de Kok, T. M.

PY - 2017/10/1

Y1 - 2017/10/1

KW - Drug-induced liver injury

KW - Microarray

KW - Toxicogenomics

KW - Ceramide

KW - ER stress

KW - Apoptosis

KW - NECROSIS-FACTOR-ALPHA

KW - INDUCED CELL-DEATH

KW - JNK ACTIVATION

KW - HEPG2 CELLS

KW - PROTEOMICS INVESTIGATIONS

KW - INDUCED HEPATOTOXICITY

KW - HUMAN HEPATOCYTES

KW - PROTEIN-KINASES

KW - CERAMIDE

KW - APOPTOSIS

U2 - 10.1016/j.taap.2017.07.014

DO - 10.1016/j.taap.2017.07.014

M3 - Article

VL - 332

SP - 100

EP - 108

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

ER -

Access to Document

10.1016/j.taap.2017.07.014