Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

J. Jiang*, K. Mathijs, L. Timmermans, S. M. Claessen, A. Hecka, J. Weusten, R. Peters, J. H. van Delft, J. C. S. Kleinjans, D. G. J. Jennen, T. M. de Kok

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)100-108
Number of pages9
JournalToxicology and Applied Pharmacology
Volume332
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • Drug-induced liver injury
  • Microarray
  • Toxicogenomics
  • Ceramide
  • ER stress
  • Apoptosis
  • NECROSIS-FACTOR-ALPHA
  • INDUCED CELL-DEATH
  • JNK ACTIVATION
  • HEPG2 CELLS
  • PROTEOMICS INVESTIGATIONS
  • INDUCED HEPATOTOXICITY
  • HUMAN HEPATOCYTES
  • PROTEIN-KINASES
  • CERAMIDE
  • APOPTOSIS

Cite this

@article{68f2bdfe28464416ad863f93cee315bf,
title = "Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury",
keywords = "Drug-induced liver injury, Microarray, Toxicogenomics, Ceramide, ER stress, Apoptosis, NECROSIS-FACTOR-ALPHA, INDUCED CELL-DEATH, JNK ACTIVATION, HEPG2 CELLS, PROTEOMICS INVESTIGATIONS, INDUCED HEPATOTOXICITY, HUMAN HEPATOCYTES, PROTEIN-KINASES, CERAMIDE, APOPTOSIS",
author = "J. Jiang and K. Mathijs and L. Timmermans and Claessen, {S. M.} and A. Hecka and J. Weusten and R. Peters and {van Delft}, {J. H.} and Kleinjans, {J. C. S.} and Jennen, {D. G. J.} and {de Kok}, {T. M.}",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.taap.2017.07.014",
language = "English",
volume = "332",
pages = "100--108",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Elsevier Science",

}

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury. / Jiang, J.; Mathijs, K.; Timmermans, L.; Claessen, S. M.; Hecka, A.; Weusten, J.; Peters, R.; van Delft, J. H.; Kleinjans, J. C. S.; Jennen, D. G. J.; de Kok, T. M.

In: Toxicology and Applied Pharmacology, Vol. 332, 01.10.2017, p. 100-108.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

AU - Jiang, J.

AU - Mathijs, K.

AU - Timmermans, L.

AU - Claessen, S. M.

AU - Hecka, A.

AU - Weusten, J.

AU - Peters, R.

AU - van Delft, J. H.

AU - Kleinjans, J. C. S.

AU - Jennen, D. G. J.

AU - de Kok, T. M.

PY - 2017/10/1

Y1 - 2017/10/1

KW - Drug-induced liver injury

KW - Microarray

KW - Toxicogenomics

KW - Ceramide

KW - ER stress

KW - Apoptosis

KW - NECROSIS-FACTOR-ALPHA

KW - INDUCED CELL-DEATH

KW - JNK ACTIVATION

KW - HEPG2 CELLS

KW - PROTEOMICS INVESTIGATIONS

KW - INDUCED HEPATOTOXICITY

KW - HUMAN HEPATOCYTES

KW - PROTEIN-KINASES

KW - CERAMIDE

KW - APOPTOSIS

U2 - 10.1016/j.taap.2017.07.014

DO - 10.1016/j.taap.2017.07.014

M3 - Article

VL - 332

SP - 100

EP - 108

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

ER -