| Original language | English |
|---|---|
| Pages (from-to) | 100-108 |
| Number of pages | 9 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 332 |
| DOIs | |
| Publication status | Published - 1 Oct 2017 |
Keywords
- Drug-induced liver injury
- Microarray
- Toxicogenomics
- Ceramide
- ER stress
- Apoptosis
- NECROSIS-FACTOR-ALPHA
- INDUCED CELL-DEATH
- JNK ACTIVATION
- HEPG2 CELLS
- PROTEOMICS INVESTIGATIONS
- INDUCED HEPATOTOXICITY
- HUMAN HEPATOCYTES
- PROTEIN-KINASES
- CERAMIDE
- APOPTOSIS
Cite this
}
Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury. / Jiang, J.; Mathijs, K.; Timmermans, L.; Claessen, S. M.; Hecka, A.; Weusten, J.; Peters, R.; van Delft, J. H.; Kleinjans, J. C. S.; Jennen, D. G. J.; de Kok, T. M.
In: Toxicology and Applied Pharmacology, Vol. 332, 01.10.2017, p. 100-108.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury
AU - Jiang, J.
AU - Mathijs, K.
AU - Timmermans, L.
AU - Claessen, S. M.
AU - Hecka, A.
AU - Weusten, J.
AU - Peters, R.
AU - van Delft, J. H.
AU - Kleinjans, J. C. S.
AU - Jennen, D. G. J.
AU - de Kok, T. M.
PY - 2017/10/1
Y1 - 2017/10/1
KW - Drug-induced liver injury
KW - Microarray
KW - Toxicogenomics
KW - Ceramide
KW - ER stress
KW - Apoptosis
KW - NECROSIS-FACTOR-ALPHA
KW - INDUCED CELL-DEATH
KW - JNK ACTIVATION
KW - HEPG2 CELLS
KW - PROTEOMICS INVESTIGATIONS
KW - INDUCED HEPATOTOXICITY
KW - HUMAN HEPATOCYTES
KW - PROTEIN-KINASES
KW - CERAMIDE
KW - APOPTOSIS
U2 - 10.1016/j.taap.2017.07.014
DO - 10.1016/j.taap.2017.07.014
M3 - Article
VL - 332
SP - 100
EP - 108
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
ER -