Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

J. Jiang*, K. Mathijs, L. Timmermans, S. M. Claessen, A. Hecka, J. Weusten, R. Peters, J. H. van Delft, J. C. S. Kleinjans, D. G. J. Jennen, T. M. de Kok

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)100-108
Number of pages9
JournalToxicology and Applied Pharmacology
Volume332
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • Drug-induced liver injury
  • Microarray
  • Toxicogenomics
  • Ceramide
  • ER stress
  • Apoptosis
  • NECROSIS-FACTOR-ALPHA
  • INDUCED CELL-DEATH
  • JNK ACTIVATION
  • HEPG2 CELLS
  • PROTEOMICS INVESTIGATIONS
  • INDUCED HEPATOTOXICITY
  • HUMAN HEPATOCYTES
  • PROTEIN-KINASES
  • CERAMIDE
  • APOPTOSIS

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