Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

J. Jiang; K. Mathijs; L. Timmermans; S. M. Claessen; A. Hecka; J. Weusten; R. Peters; J. H. van Delft; J. C. S. Kleinjans; D. G. J. Jennen; T. M. de Kok

doi:10.1016/j.taap.2017.07.014

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

J. Jiang^*, K. Mathijs, L. Timmermans, S. M. Claessen, A. Hecka, J. Weusten, R. Peters, J. H. van Delft, J. C. S. Kleinjans, D. G. J. Jennen, T. M. de Kok

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	100-108
Number of pages	9
Journal	Toxicology and Applied Pharmacology
Volume	332
DOIs	https://doi.org/10.1016/j.taap.2017.07.014
Publication status	Published - 1 Oct 2017

Keywords

Drug-induced liver injury
Microarray
Toxicogenomics
Ceramide
ER stress
Apoptosis
NECROSIS-FACTOR-ALPHA
INDUCED CELL-DEATH
JNK ACTIVATION
HEPG2 CELLS
PROTEOMICS INVESTIGATIONS
INDUCED HEPATOTOXICITY
HUMAN HEPATOCYTES
PROTEIN-KINASES
CERAMIDE
APOPTOSIS

Access to Document

10.1016/j.taap.2017.07.014

Cite this

Jiang, J., Mathijs, K., Timmermans, L., Claessen, S. M., Hecka, A., Weusten, J., Peters, R., van Delft, J. H., Kleinjans, J. C. S., Jennen, D. G. J., & de Kok, T. M. (2017). Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury. Toxicology and Applied Pharmacology, 332, 100-108. https://doi.org/10.1016/j.taap.2017.07.014

Jiang, J. ; Mathijs, K. ; Timmermans, L. ; Claessen, S. M. ; Hecka, A. ; Weusten, J. ; Peters, R. ; van Delft, J. H. ; Kleinjans, J. C. S. ; Jennen, D. G. J. ; de Kok, T. M. / Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury. In: Toxicology and Applied Pharmacology. 2017 ; Vol. 332. pp. 100-108.

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title = "Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury",

keywords = "Drug-induced liver injury, Microarray, Toxicogenomics, Ceramide, ER stress, Apoptosis, NECROSIS-FACTOR-ALPHA, INDUCED CELL-DEATH, JNK ACTIVATION, HEPG2 CELLS, PROTEOMICS INVESTIGATIONS, INDUCED HEPATOTOXICITY, HUMAN HEPATOCYTES, PROTEIN-KINASES, CERAMIDE, APOPTOSIS",

author = "J. Jiang and K. Mathijs and L. Timmermans and Claessen, {S. M.} and A. Hecka and J. Weusten and R. Peters and {van Delft}, {J. H.} and Kleinjans, {J. C. S.} and Jennen, {D. G. J.} and {de Kok}, {T. M.}",

year = "2017",

month = oct,

day = "1",

doi = "10.1016/j.taap.2017.07.014",

language = "English",

volume = "332",

pages = "100--108",

journal = "Toxicology and Applied Pharmacology",

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Jiang, J, Mathijs, K, Timmermans, L, Claessen, SM, Hecka, A, Weusten, J, Peters, R, van Delft, JH, Kleinjans, JCS , Jennen, DGJ & de Kok, TM 2017, 'Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury', Toxicology and Applied Pharmacology, vol. 332, pp. 100-108. https://doi.org/10.1016/j.taap.2017.07.014

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury. / Jiang, J.; Mathijs, K.; Timmermans, L.; Claessen, S. M.; Hecka, A.; Weusten, J.; Peters, R.; van Delft, J. H.; Kleinjans, J. C. S.; Jennen, D. G. J.; de Kok, T. M.

In: Toxicology and Applied Pharmacology, Vol. 332, 01.10.2017, p. 100-108.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

AU - Jiang, J.

AU - Mathijs, K.

AU - Timmermans, L.

AU - Claessen, S. M.

AU - Hecka, A.

AU - Weusten, J.

AU - Peters, R.

AU - van Delft, J. H.

AU - Kleinjans, J. C. S.

AU - Jennen, D. G. J.

AU - de Kok, T. M.

PY - 2017/10/1

Y1 - 2017/10/1

KW - Drug-induced liver injury

KW - Microarray

KW - Toxicogenomics

KW - Ceramide

KW - ER stress

KW - Apoptosis

KW - NECROSIS-FACTOR-ALPHA

KW - INDUCED CELL-DEATH

KW - JNK ACTIVATION

KW - HEPG2 CELLS

KW - PROTEOMICS INVESTIGATIONS

KW - INDUCED HEPATOTOXICITY

KW - HUMAN HEPATOCYTES

KW - PROTEIN-KINASES

KW - CERAMIDE

KW - APOPTOSIS

U2 - 10.1016/j.taap.2017.07.014

DO - 10.1016/j.taap.2017.07.014

M3 - Article

VL - 332

SP - 100

EP - 108

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

ER -