Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro.

D.M.A.E. Jonkers, E.E. Stobberingh, R.W. Stockbrügger

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Abstract

Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro.

Jonkers D, Stobberingh E, Stockbrugger R.

Department of Gastroenterology, University of Limburg, The Netherlands.

The antibacterial effects of omeprazole (100, 200 and 300 mg/L) were assessed using bacterial growth curves. A dose-related permanent inhibition was seen with actively growing Gram-positive cocci. A reduced and only temporary effect was observed with Gram-negative bacilli. After 1 day the bacterial count of Helicobacter pylori in the presence of omeprazole 200 mg/L was reduced from 10(4) cfu/mL for the control to zero. No synergic or antagonistic interaction of omeprazole with amoxycillin or doxycycline was observed for Escherichia coli and Enterococcus faecalis.
Original languageEnglish
Pages (from-to)145-150
JournalJournal of Antimicrobial Chemotherapy
Volume37
DOIs
Publication statusPublished - 1 Jan 1996

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