Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours

Ruth Plummer; Helen Swaisland; Karin Leunen; Carla M. L. van Herpen; Guy Jerusalem; Jacques De Greve; Martijn P. Lolkema; Patricia Soetekouw; Morten Mau-Sorensen; Dorte Nielsen; James Spicer; Anitra Fielding; Karen So; Wendy Bannister; L. Rhoda Molife

doi:10.1007/s00280-015-2836-2

Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours

Ruth Plummer, Helen Swaisland, Karin Leunen, Carla M. L. van Herpen, Guy Jerusalem, Jacques De Greve, Martijn P. Lolkema, Patricia Soetekouw, Morten Mau-Sorensen, Dorte Nielsen, James Spicer, Anitra Fielding, Karen So, Wendy Bannister, L. Rhoda Molife

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Original language	English
Pages (from-to)	723-729
Journal	Cancer Chemotherapy and Pharmacology
Volume	76
Issue number	4
DOIs	https://doi.org/10.1007/s00280-015-2836-2
Publication status	Published - Oct 2015

Keywords

Olaparib
Food effect
Tablet
PARP inhibition
PK

Cite this

Plummer, R., Swaisland, H., Leunen, K., van Herpen, C. M. L., Jerusalem, G., De Greve, J., Lolkema, M. P., Soetekouw, P., Mau-Sorensen, M., Nielsen, D., Spicer, J., Fielding, A., So, K., Bannister, W., & Molife, L. R. (2015). Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours. Cancer Chemotherapy and Pharmacology, 76(4), 723-729. https://doi.org/10.1007/s00280-015-2836-2

Plummer, Ruth ; Swaisland, Helen ; Leunen, Karin ; van Herpen, Carla M. L. ; Jerusalem, Guy ; De Greve, Jacques ; Lolkema, Martijn P. ; Soetekouw, Patricia ; Mau-Sorensen, Morten ; Nielsen, Dorte ; Spicer, James ; Fielding, Anitra ; So, Karen ; Bannister, Wendy ; Molife, L. Rhoda. / Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours. In: Cancer Chemotherapy and Pharmacology. 2015 ; Vol. 76, No. 4. pp. 723-729.

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title = "Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours",

keywords = "Olaparib, Food effect, Tablet, PARP inhibition, PK",

author = "Ruth Plummer and Helen Swaisland and Karin Leunen and {van Herpen}, {Carla M. L.} and Guy Jerusalem and {De Greve}, Jacques and Lolkema, {Martijn P.} and Patricia Soetekouw and Morten Mau-Sorensen and Dorte Nielsen and James Spicer and Anitra Fielding and Karen So and Wendy Bannister and Molife, {L. Rhoda}",

year = "2015",

month = oct,

doi = "10.1007/s00280-015-2836-2",

language = "English",

volume = "76",

pages = "723--729",

journal = "Cancer Chemotherapy and Pharmacology",

issn = "0344-5704",

publisher = "Springer Verlag",

number = "4",

}

Plummer, R, Swaisland, H, Leunen, K, van Herpen, CML, Jerusalem, G, De Greve, J, Lolkema, MP, Soetekouw, P, Mau-Sorensen, M, Nielsen, D, Spicer, J, Fielding, A, So, K, Bannister, W & Molife, LR 2015, 'Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours', Cancer Chemotherapy and Pharmacology, vol. 76, no. 4, pp. 723-729. https://doi.org/10.1007/s00280-015-2836-2

Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours. / Plummer, Ruth; Swaisland, Helen; Leunen, Karin; van Herpen, Carla M. L.; Jerusalem, Guy; De Greve, Jacques; Lolkema, Martijn P.; Soetekouw, Patricia; Mau-Sorensen, Morten; Nielsen, Dorte; Spicer, James; Fielding, Anitra; So, Karen; Bannister, Wendy; Molife, L. Rhoda.

In: Cancer Chemotherapy and Pharmacology, Vol. 76, No. 4, 10.2015, p. 723-729.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours

AU - Plummer, Ruth

AU - Swaisland, Helen

AU - Leunen, Karin

AU - van Herpen, Carla M. L.

AU - Jerusalem, Guy

AU - De Greve, Jacques

AU - Lolkema, Martijn P.

AU - Soetekouw, Patricia

AU - Mau-Sorensen, Morten

AU - Nielsen, Dorte

AU - Spicer, James

AU - Fielding, Anitra

AU - So, Karen

AU - Bannister, Wendy

AU - Molife, L. Rhoda

PY - 2015/10

Y1 - 2015/10

KW - Olaparib

KW - Food effect

KW - Tablet

KW - PARP inhibition

KW - PK

U2 - 10.1007/s00280-015-2836-2

DO - 10.1007/s00280-015-2836-2

M3 - Article

VL - 76

SP - 723

EP - 729

JO - Cancer Chemotherapy and Pharmacology

JF - Cancer Chemotherapy and Pharmacology

SN - 0344-5704

IS - 4

ER -

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10.1007/s00280-015-2836-2