Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours

Ruth Plummer; Helen Swaisland; Karin Leunen; Carla M. L. van Herpen; Guy Jerusalem; Jacques De Greve; Martijn P. Lolkema; Patricia Soetekouw; Morten Mau-Sorensen; Dorte Nielsen; James Spicer; Anitra Fielding; Karen So; Wendy Bannister; L. Rhoda Molife

doi:10.1007/s00280-015-2836-2

Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours

Ruth Plummer^*, Helen Swaisland, Karin Leunen, Carla M. L. van Herpen, Guy Jerusalem, Jacques De Greve, Martijn P. Lolkema, Patricia Soetekouw, Morten Mau-Sorensen, Dorte Nielsen, James Spicer, Anitra Fielding, Karen So, Wendy Bannister, L. Rhoda Molife

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

33 Citations (Web of Science)

Original language	English
Pages (from-to)	723-729
Journal	Cancer Chemotherapy and Pharmacology
Volume	76
Issue number	4
DOIs	https://doi.org/10.1007/s00280-015-2836-2
Publication status	Published - Oct 2015

Keywords

Olaparib
Food effect
Tablet
PARP inhibition
PK

Access to Document

10.1007/s00280-015-2836-2

Cite this

Plummer, R., Swaisland, H., Leunen, K., van Herpen, C. M. L., Jerusalem, G., De Greve, J., Lolkema, M. P., Soetekouw, P., Mau-Sorensen, M., Nielsen, D., Spicer, J., Fielding, A., So, K., Bannister, W., & Molife, L. R. (2015). Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours. Cancer Chemotherapy and Pharmacology, 76(4), 723-729. https://doi.org/10.1007/s00280-015-2836-2

Plummer, Ruth ; Swaisland, Helen ; Leunen, Karin ; van Herpen, Carla M. L. ; Jerusalem, Guy ; De Greve, Jacques ; Lolkema, Martijn P. ; Soetekouw, Patricia ; Mau-Sorensen, Morten ; Nielsen, Dorte ; Spicer, James ; Fielding, Anitra ; So, Karen ; Bannister, Wendy ; Molife, L. Rhoda. / Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours. In: Cancer Chemotherapy and Pharmacology. 2015 ; Vol. 76, No. 4. pp. 723-729.

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title = "Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours",

keywords = "Olaparib, Food effect, Tablet, PARP inhibition, PK",

author = "Ruth Plummer and Helen Swaisland and Karin Leunen and {van Herpen}, {Carla M. L.} and Guy Jerusalem and {De Greve}, Jacques and Lolkema, {Martijn P.} and Patricia Soetekouw and Morten Mau-Sorensen and Dorte Nielsen and James Spicer and Anitra Fielding and Karen So and Wendy Bannister and Molife, {L. Rhoda}",

year = "2015",

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doi = "10.1007/s00280-015-2836-2",

language = "English",

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journal = "Cancer Chemotherapy and Pharmacology",

issn = "0344-5704",

publisher = "Springer Verlag",

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}

Plummer, R, Swaisland, H, Leunen, K, van Herpen, CML, Jerusalem, G, De Greve, J, Lolkema, MP, Soetekouw, P, Mau-Sorensen, M, Nielsen, D, Spicer, J, Fielding, A, So, K, Bannister, W & Molife, LR 2015, 'Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours', Cancer Chemotherapy and Pharmacology, vol. 76, no. 4, pp. 723-729. https://doi.org/10.1007/s00280-015-2836-2

Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours. / Plummer, Ruth; Swaisland, Helen; Leunen, Karin; van Herpen, Carla M. L.; Jerusalem, Guy; De Greve, Jacques; Lolkema, Martijn P.; Soetekouw, Patricia; Mau-Sorensen, Morten; Nielsen, Dorte; Spicer, James; Fielding, Anitra; So, Karen; Bannister, Wendy; Molife, L. Rhoda.

In: Cancer Chemotherapy and Pharmacology, Vol. 76, No. 4, 10.2015, p. 723-729.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Olaparib tablet formulation: effect of food on the pharmacokinetics after oral dosing in patients with advanced solid tumours

AU - Plummer, Ruth

AU - Swaisland, Helen

AU - Leunen, Karin

AU - van Herpen, Carla M. L.

AU - Jerusalem, Guy

AU - De Greve, Jacques

AU - Lolkema, Martijn P.

AU - Soetekouw, Patricia

AU - Mau-Sorensen, Morten

AU - Nielsen, Dorte

AU - Spicer, James

AU - Fielding, Anitra

AU - So, Karen

AU - Bannister, Wendy

AU - Molife, L. Rhoda

PY - 2015/10

Y1 - 2015/10

KW - Olaparib

KW - Food effect

KW - Tablet

KW - PARP inhibition

KW - PK

U2 - 10.1007/s00280-015-2836-2

DO - 10.1007/s00280-015-2836-2

M3 - Article

C2 - 26242220

VL - 76

SP - 723

EP - 729

JO - Cancer Chemotherapy and Pharmacology

JF - Cancer Chemotherapy and Pharmacology

SN - 0344-5704

IS - 4

ER -