Ocular Hypertension and the Risk of Blindness

A. van Gestel, C.A.B. Webers, H.J.M. Beckers, A. Peeters, J.L. Severens, J.S.A.G. Schouten

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: To estimate the risk of blindness in patients with ocular hypertension (OHT) using an appropriate model and current empirical data.

Design: A Markov model with data from a systematic literature review.

Methods: A Markov model with 3 health states was built: OHT, primary open-angle glaucoma (POAG), and unilateral blindness. Literature was searched for reports on conversion from OHT to POAG and progression from POAG to blindness, to estimate a range of annual conversion and progression probabilities. The model had a cycle length of 1 year.

Results: The 15-year risk estimates ranged from 3.1% to 9.4% in untreated, and from 0.9% to 8.6% in treated patients with OHT. The ranges were the result of differences in patient populations, treatments, and outcome definitions in currently available empirical data.

Conclusions: The best estimates of the 15-year risk of unilateral blindness in patients with OHT, based on the currently available empirical data and an appropriate model, show that the risk is

Original languageEnglish
Pages (from-to)9-11
Number of pages3
JournalJournal of Glaucoma
Volume24
Issue number1
Early online date20 Mar 2013
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • ocular hypertension
  • blindness
  • Markov model
  • OPEN-ANGLE GLAUCOMA
  • TERM CLINICAL-TRIAL
  • VISUAL-FIELD LOSS
  • RANDOMIZED TRIAL
  • TIMOLOL THERAPY
  • MANAGEMENT
  • SUSPECTS

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