OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency

M. Ullrich; M. Weber; A. M. Post; S. Popp; J. Grein; M. Zechner; H. Guerrero Gonzalez; A. Kreis; A. G. Schmitt; N. Uceyler; K-P Lesch; K. Schuh

doi:10.1038/mp.2016.232

OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency

M. Ullrich, M. Weber, A. M. Post, S. Popp, J. Grein, M. Zechner, H. Guerrero Gonzalez, A. Kreis, A. G. Schmitt, N. Uceyler, K-P Lesch, K. Schuh

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	444-458
Number of pages	15
Journal	Molecular Psychiatry
Volume	23
Issue number	2
DOIs	https://doi.org/10.1038/mp.2016.232
Publication status	Published - 1 Feb 2018

Keywords

OBSESSIVE-COMPULSIVE DISORDER
METABOTROPIC GLUTAMATE RECEPTORS
NEUROTROPHIC FACTOR
SYNAPTIC PLASTICITY
POSTSYNAPTIC DENSITY
ANXIETY DISORDER
MOUSE MODELS
ACTIVE ZONE
BDNF
ROLES

Access to Document

10.1038/mp.2016.232

https://www.nature.com/articles/mp2016232.pdf

Cite this

Ullrich, M., Weber, M., Post, A. M., Popp, S., Grein, J., Zechner, M., Gonzalez, H. G., Kreis, A., Schmitt, A. G., Uceyler, N., Lesch, K-P., & Schuh, K. (2018). OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency. Molecular Psychiatry, 23(2), 444-458. https://doi.org/10.1038/mp.2016.232

Ullrich, M. ; Weber, M. ; Post, A. M. ; Popp, S. ; Grein, J. ; Zechner, M. ; Gonzalez, H. Guerrero ; Kreis, A. ; Schmitt, A. G. ; Uceyler, N. ; Lesch, K-P ; Schuh, K. / OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency. In: Molecular Psychiatry. 2018 ; Vol. 23, No. 2. pp. 444-458.

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keywords = "OBSESSIVE-COMPULSIVE DISORDER, METABOTROPIC GLUTAMATE RECEPTORS, NEUROTROPHIC FACTOR, SYNAPTIC PLASTICITY, POSTSYNAPTIC DENSITY, ANXIETY DISORDER, MOUSE MODELS, ACTIVE ZONE, BDNF, ROLES",

author = "M. Ullrich and M. Weber and Post, {A. M.} and S. Popp and J. Grein and M. Zechner and Gonzalez, {H. Guerrero} and A. Kreis and Schmitt, {A. G.} and N. Uceyler and K-P Lesch and K. Schuh",

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Ullrich, M, Weber, M, Post, AM, Popp, S, Grein, J, Zechner, M, Gonzalez, HG, Kreis, A, Schmitt, AG, Uceyler, N, Lesch, K-P & Schuh, K 2018, 'OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency', Molecular Psychiatry, vol. 23, no. 2, pp. 444-458. https://doi.org/10.1038/mp.2016.232

OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency. / Ullrich, M.; Weber, M.; Post, A. M.; Popp, S.; Grein, J.; Zechner, M.; Gonzalez, H. Guerrero; Kreis, A.; Schmitt, A. G.; Uceyler, N.; Lesch, K-P; Schuh, K.

In: Molecular Psychiatry, Vol. 23, No. 2, 01.02.2018, p. 444-458.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency

AU - Ullrich, M.

AU - Weber, M.

AU - Post, A. M.

AU - Popp, S.

AU - Grein, J.

AU - Zechner, M.

AU - Gonzalez, H. Guerrero

AU - Kreis, A.

AU - Schmitt, A. G.

AU - Uceyler, N.

AU - Lesch, K-P

AU - Schuh, K.

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KW - METABOTROPIC GLUTAMATE RECEPTORS

KW - NEUROTROPHIC FACTOR

KW - SYNAPTIC PLASTICITY

KW - POSTSYNAPTIC DENSITY

KW - ANXIETY DISORDER

KW - MOUSE MODELS

KW - ACTIVE ZONE

KW - BDNF

KW - ROLES

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DO - 10.1038/mp.2016.232

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SP - 444

EP - 458

JO - Molecular Psychiatry

JF - Molecular Psychiatry

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ER -