Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study

T. Koeman, L.J. Schouten, P.A. van den Brandt, P. Slottje, A. Huss, S. Peters, H. Kromhout, R. Vermeulen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BackgroundOccupational exposures may be associated with non-vascular dementia.

MethodsWe analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.

ResultsOccupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.

ConclusionsConsistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature. Am. J. Ind. Med. 58:625-635, 2015. (c) 2015 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)625-635
Number of pages11
JournalAmerican Journal of Industrial Medicine
Volume58
Issue number6
DOIs
Publication statusPublished - Jun 2015

Keywords

  • cohort
  • dementia
  • Alzheimer's disease
  • occupation
  • extremely low frequency magnetic fields
  • pesticides
  • metals
  • solvents
  • diesel motor exhaust
  • FREQUENCY MAGNETIC-FIELDS
  • ALZHEIMERS-DISEASE
  • NEURODEGENERATIVE DISEASES
  • PESTICIDE EXPOSURE
  • AIR-POLLUTION
  • AMYLOID-BETA
  • WORKERS
  • POPULATION
  • COMMUNITY
  • ALUMINUM

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