Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study

Nils Swindell; Kelly Mackintosh; Melitta McNarry; Jeffrey W. Stephens; Diewertje Sluik; Mikael Fogelholm; Mathijs Drummen; Ian MacDonald; J. Alfredo Martinez; Teodora Handjieva-Darlenska; Sally D. Poppitt; Jennie Brand-Miller; Thomas M. Larsen; Anne Raben; Gareth Stratton

doi:10.2337/dc17-1057

Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study

Nils Swindell^*, Kelly Mackintosh, Melitta McNarry, Jeffrey W. Stephens, Diewertje Sluik, Mikael Fogelholm, Mathijs Drummen, Ian MacDonald, J. Alfredo Martinez, Teodora Handjieva-Darlenska, Sally D. Poppitt, Jennie Brand-Miller, Thomas M. Larsen, Anne Raben, Gareth Stratton

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI > 25 kg.m(-2) and impaired fasting glucose (5.6-6.9 mmol.L-1) or impaired glucose tolerance (7.8-11.0 mmol.L-1 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST. RESULTS Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized beta = -0.078 [95% CI-0.128, -0.027]), waist circumference (WC) (beta = -0.177 [-0.122, -0.134]), fasting insulin (beta = -0.115 [-0.158, -0.072]), 2-h glucose (beta = -0.069 [-0.112, -0.025]), triglycerides (beta = -0.091 [-0.138, -0.044]), and CRP (beta = -0.086 [-0.127, -0.045]). ST was positively associated with HOMA-IR (beta = 0.175 [0.114, 0.236]), WC (beta = 0.215 [0.026, 0.131]), fasting insulin (beta = 0.155 [0.092, 0.219]), triglycerides (beta = 0.106 [0.052, 0.16]), CRP (beta = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (beta = 0.078 [0.026, 0.131]), and diastolic BP (beta = 0.106 [0.39, -0.172]). Associations reported between total PA (counts . min(-1)), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (beta = -0.151 [-0.194, -0.107]), WC (beta = -0.179 [-0.224, -0.134]), fasting insulin (beta = -0.139 [-0.183, -0.096]), 2-h glucose (beta = -0.088 [-0.131, -0.045]), triglycerides (beta = -0.117 [-0.162, -0.071]), and CRP (beta = -0.104 [-0.146, -0.062]). CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.

Original language	English
Pages (from-to)	562-569
Number of pages	8
Journal	Diabetes Care
Volume	41
Issue number	3
DOIs	https://doi.org/10.2337/dc17-1057
Publication status	Published - 1 Mar 2018

Keywords

INSULIN SENSITIVITY
LIPASE ACTIVITY
METABOLIC RISK
LIFE
INDIVIDUALS
INACTIVITY
WORLDWIDE
VALIDITY
DISEASE

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Swindell, N., Mackintosh, K., McNarry, M., Stephens, J. W., Sluik, D., Fogelholm, M., Drummen, M., MacDonald, I., Martinez, J. A., Handjieva-Darlenska, T., Poppitt, S. D., Brand-Miller, J., Larsen, T. M., Raben, A., & Stratton, G. (2018). Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study. Diabetes Care, 41(3), 562-569. https://doi.org/10.2337/dc17-1057

@article{f84d94d6d58144a2a89be3e5d4d1e863,

title = "Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study",

abstract = "OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI > 25 kg.m(-2) and impaired fasting glucose (5.6-6.9 mmol.L-1) or impaired glucose tolerance (7.8-11.0 mmol.L-1 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST. RESULTS Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized beta = -0.078 [95% CI-0.128, -0.027]), waist circumference (WC) (beta = -0.177 [-0.122, -0.134]), fasting insulin (beta = -0.115 [-0.158, -0.072]), 2-h glucose (beta = -0.069 [-0.112, -0.025]), triglycerides (beta = -0.091 [-0.138, -0.044]), and CRP (beta = -0.086 [-0.127, -0.045]). ST was positively associated with HOMA-IR (beta = 0.175 [0.114, 0.236]), WC (beta = 0.215 [0.026, 0.131]), fasting insulin (beta = 0.155 [0.092, 0.219]), triglycerides (beta = 0.106 [0.052, 0.16]), CRP (beta = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (beta = 0.078 [0.026, 0.131]), and diastolic BP (beta = 0.106 [0.39, -0.172]). Associations reported between total PA (counts . min(-1)), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (beta = -0.151 [-0.194, -0.107]), WC (beta = -0.179 [-0.224, -0.134]), fasting insulin (beta = -0.139 [-0.183, -0.096]), 2-h glucose (beta = -0.088 [-0.131, -0.045]), triglycerides (beta = -0.117 [-0.162, -0.071]), and CRP (beta = -0.104 [-0.146, -0.062]). CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.",

keywords = "INSULIN SENSITIVITY, LIPASE ACTIVITY, METABOLIC RISK, LIFE, INDIVIDUALS, INACTIVITY, WORLDWIDE, VALIDITY, DISEASE",

author = "Nils Swindell and Kelly Mackintosh and Melitta McNarry and Stephens, {Jeffrey W.} and Diewertje Sluik and Mikael Fogelholm and Mathijs Drummen and Ian MacDonald and Martinez, {J. Alfredo} and Teodora Handjieva-Darlenska and Poppitt, {Sally D.} and Jennie Brand-Miller and Larsen, {Thomas M.} and Anne Raben and Gareth Stratton",

year = "2018",

month = mar,

day = "1",

doi = "10.2337/dc17-1057",

language = "English",

volume = "41",

pages = "562--569",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association",

number = "3",

}

Swindell, N, Mackintosh, K, McNarry, M, Stephens, JW, Sluik, D, Fogelholm, M, Drummen, M, MacDonald, I, Martinez, JA, Handjieva-Darlenska, T, Poppitt, SD, Brand-Miller, J, Larsen, TM, Raben, A & Stratton, G 2018, 'Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study', Diabetes Care, vol. 41, no. 3, pp. 562-569. https://doi.org/10.2337/dc17-1057

TY - JOUR

T1 - Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study

AU - Swindell, Nils

AU - Mackintosh, Kelly

AU - McNarry, Melitta

AU - Stephens, Jeffrey W.

AU - Sluik, Diewertje

AU - Fogelholm, Mikael

AU - Drummen, Mathijs

AU - MacDonald, Ian

AU - Martinez, J. Alfredo

AU - Handjieva-Darlenska, Teodora

AU - Poppitt, Sally D.

AU - Brand-Miller, Jennie

AU - Larsen, Thomas M.

AU - Raben, Anne

AU - Stratton, Gareth

PY - 2018/3/1

Y1 - 2018/3/1

N2 - OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI > 25 kg.m(-2) and impaired fasting glucose (5.6-6.9 mmol.L-1) or impaired glucose tolerance (7.8-11.0 mmol.L-1 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST. RESULTS Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized beta = -0.078 [95% CI-0.128, -0.027]), waist circumference (WC) (beta = -0.177 [-0.122, -0.134]), fasting insulin (beta = -0.115 [-0.158, -0.072]), 2-h glucose (beta = -0.069 [-0.112, -0.025]), triglycerides (beta = -0.091 [-0.138, -0.044]), and CRP (beta = -0.086 [-0.127, -0.045]). ST was positively associated with HOMA-IR (beta = 0.175 [0.114, 0.236]), WC (beta = 0.215 [0.026, 0.131]), fasting insulin (beta = 0.155 [0.092, 0.219]), triglycerides (beta = 0.106 [0.052, 0.16]), CRP (beta = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (beta = 0.078 [0.026, 0.131]), and diastolic BP (beta = 0.106 [0.39, -0.172]). Associations reported between total PA (counts . min(-1)), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (beta = -0.151 [-0.194, -0.107]), WC (beta = -0.179 [-0.224, -0.134]), fasting insulin (beta = -0.139 [-0.183, -0.096]), 2-h glucose (beta = -0.088 [-0.131, -0.045]), triglycerides (beta = -0.117 [-0.162, -0.071]), and CRP (beta = -0.104 [-0.146, -0.062]). CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.

AB - OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI > 25 kg.m(-2) and impaired fasting glucose (5.6-6.9 mmol.L-1) or impaired glucose tolerance (7.8-11.0 mmol.L-1 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST. RESULTS Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized beta = -0.078 [95% CI-0.128, -0.027]), waist circumference (WC) (beta = -0.177 [-0.122, -0.134]), fasting insulin (beta = -0.115 [-0.158, -0.072]), 2-h glucose (beta = -0.069 [-0.112, -0.025]), triglycerides (beta = -0.091 [-0.138, -0.044]), and CRP (beta = -0.086 [-0.127, -0.045]). ST was positively associated with HOMA-IR (beta = 0.175 [0.114, 0.236]), WC (beta = 0.215 [0.026, 0.131]), fasting insulin (beta = 0.155 [0.092, 0.219]), triglycerides (beta = 0.106 [0.052, 0.16]), CRP (beta = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (beta = 0.078 [0.026, 0.131]), and diastolic BP (beta = 0.106 [0.39, -0.172]). Associations reported between total PA (counts . min(-1)), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (beta = -0.151 [-0.194, -0.107]), WC (beta = -0.179 [-0.224, -0.134]), fasting insulin (beta = -0.139 [-0.183, -0.096]), 2-h glucose (beta = -0.088 [-0.131, -0.045]), triglycerides (beta = -0.117 [-0.162, -0.071]), and CRP (beta = -0.104 [-0.146, -0.062]). CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.

KW - INSULIN SENSITIVITY

KW - LIPASE ACTIVITY

KW - METABOLIC RISK

KW - LIFE

KW - INDIVIDUALS

KW - INACTIVITY

KW - WORLDWIDE

KW - VALIDITY

KW - DISEASE

U2 - 10.2337/dc17-1057

DO - 10.2337/dc17-1057

M3 - Article

C2 - 29158249

SN - 0149-5992

VL - 41

SP - 562

EP - 569

JO - Diabetes Care

JF - Diabetes Care

IS - 3

ER -